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Protein

50S ribosomal protein L5

Gene

rplE

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L5UniRule annotation
Gene namesi
Name:rplEUniRule annotation
Ordered Locus Names:TT_C1316
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 18218150S ribosomal protein L5PRO_0000125013Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation

Structurei

Secondary structure

1
182
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 127Combined sources
Helixi15 – 228Combined sources
Turni28 – 303Combined sources
Beta strandi36 – 394Combined sources
Turni45 – 484Combined sources
Helixi50 – 6415Combined sources
Beta strandi69 – 713Combined sources
Turni78 – 814Combined sources
Beta strandi90 – 945Combined sources
Helixi96 – 10813Combined sources
Helixi110 – 1134Combined sources
Helixi122 – 1243Combined sources
Beta strandi127 – 13610Combined sources
Helixi138 – 1403Combined sources
Beta strandi141 – 1433Combined sources
Turni146 – 1483Combined sources
Beta strandi155 – 16511Combined sources
Helixi166 – 17510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71E1-182[»]
4V4JX-ray3.83E1-182[»]
4V63X-ray3.21BG/DG1-182[»]
4V67X-ray3.00BG/DG1-182[»]
4V7PX-ray3.62BF/CF2-182[»]
4V83X-ray3.50BF/DF2-182[»]
4V84X-ray3.40BF/DF2-182[»]
4V9JX-ray3.86BG/DG2-182[»]
4V9KX-ray3.50BG/DG2-182[»]
4V9LX-ray3.50BG/DG2-182[»]
4V9MX-ray4.00BG/DG2-182[»]
4V9NX-ray3.40BG/DG2-182[»]
4V9QX-ray3.40AG/CG2-182[»]
4W29X-ray3.80BG/DG2-182[»]
ProteinModelPortaliQ72I16.
SMRiQ72I16. Positions 3-182.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72I16.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L5P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0094.
KOiK02931.
OMAiEQVMFHE.
OrthoDBiEOG6M9F1R.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
HAMAPiMF_01333_B. Ribosomal_L5_B.
InterProiIPR002132. Ribosomal_L5.
IPR020930. Ribosomal_L5_bac-type.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
[Graphical view]
PANTHERiPTHR11994. PTHR11994. 1 hit.
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q72I16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLDLALKRK YYEEVRPELI RRFGYQNVWE VPRLEKVVIN QGLGEAKEDA
60 70 80 90 100
RILEKAAQEL ALITGQKPAV TRAKKSISNF KLRKGMPIGL RVTLRRDRMW
110 120 130 140 150
IFLEKLLNVA LPRIRDFRGL NPNSFDGRGN YNLGLREQLI FPEITYDMVD
160 170 180
ALRGMDIAVV TTAETDEEAR ALLELLGFPF RK
Length:182
Mass (Da):21,044
Last modified:January 23, 2007 - v3
Checksum:iC3A8E0CFD884EEEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81658.1.
RefSeqiYP_005285.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81658; AAS81658; TT_C1316.
KEGGitth:TTC1316.
PATRICi23953039. VBITheThe54392_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81658.1.
RefSeqiYP_005285.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71E1-182[»]
4V4JX-ray3.83E1-182[»]
4V63X-ray3.21BG/DG1-182[»]
4V67X-ray3.00BG/DG1-182[»]
4V7PX-ray3.62BF/CF2-182[»]
4V83X-ray3.50BF/DF2-182[»]
4V84X-ray3.40BF/DF2-182[»]
4V9JX-ray3.86BG/DG2-182[»]
4V9KX-ray3.50BG/DG2-182[»]
4V9LX-ray3.50BG/DG2-182[»]
4V9MX-ray4.00BG/DG2-182[»]
4V9NX-ray3.40BG/DG2-182[»]
4V9QX-ray3.40AG/CG2-182[»]
4W29X-ray3.80BG/DG2-182[»]
ProteinModelPortaliQ72I16.
SMRiQ72I16. Positions 3-182.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS81658; AAS81658; TT_C1316.
KEGGitth:TTC1316.
PATRICi23953039. VBITheThe54392_1308.

Phylogenomic databases

eggNOGiCOG0094.
KOiK02931.
OMAiEQVMFHE.
OrthoDBiEOG6M9F1R.

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1331-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ72I16.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
HAMAPiMF_01333_B. Ribosomal_L5_B.
InterProiIPR002132. Ribosomal_L5.
IPR020930. Ribosomal_L5_bac-type.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
[Graphical view]
PANTHERiPTHR11994. PTHR11994. 1 hit.
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiRL5_THET2
AccessioniPrimary (citable) accession number: Q72I16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.