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Protein

50S ribosomal protein L5

Gene

rplE

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L5UniRule annotation
Gene namesi
Name:rplEUniRule annotation
Ordered Locus Names:TT_C1316
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001250132 – 18250S ribosomal protein L5Add BLAST181

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1316.

Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 12Combined sources7
Helixi15 – 22Combined sources8
Turni28 – 30Combined sources3
Beta strandi36 – 39Combined sources4
Turni45 – 48Combined sources4
Helixi50 – 64Combined sources15
Beta strandi69 – 71Combined sources3
Turni78 – 81Combined sources4
Beta strandi90 – 94Combined sources5
Helixi96 – 108Combined sources13
Helixi110 – 113Combined sources4
Helixi122 – 124Combined sources3
Beta strandi127 – 136Combined sources10
Helixi138 – 140Combined sources3
Beta strandi141 – 143Combined sources3
Turni146 – 148Combined sources3
Beta strandi155 – 165Combined sources11
Helixi166 – 175Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71E1-182[»]
4V4JX-ray3.83E1-182[»]
4V63X-ray3.21BG/DG1-182[»]
4V67X-ray3.00BG/DG1-182[»]
4V7PX-ray3.62BF/CF2-182[»]
4V83X-ray3.50BF/DF2-182[»]
4V84X-ray3.40BF/DF2-182[»]
4V9JX-ray3.86BG/DG2-182[»]
4V9KX-ray3.50BG/DG2-182[»]
4V9LX-ray3.50BG/DG2-182[»]
4V9MX-ray4.00BG/DG2-182[»]
4V9NX-ray3.40BG/DG2-182[»]
4V9QX-ray3.40AG/CG2-182[»]
4W29X-ray3.80BG/DG2-182[»]
4XEJX-ray3.80AL05/BL052-182[»]
5J4DX-ray3.10H/MB1-182[»]
ProteinModelPortaliQ72I16.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72I16.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L5P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CW6. Bacteria.
COG0094. LUCA.
KOiK02931.
OMAiEQVMFHE.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
HAMAPiMF_01333_B. Ribosomal_L5_B. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR020930. Ribosomal_L5_bac-type.
IPR031309. Ribosomal_L5_C.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
[Graphical view]
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q72I16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLDLALKRK YYEEVRPELI RRFGYQNVWE VPRLEKVVIN QGLGEAKEDA
60 70 80 90 100
RILEKAAQEL ALITGQKPAV TRAKKSISNF KLRKGMPIGL RVTLRRDRMW
110 120 130 140 150
IFLEKLLNVA LPRIRDFRGL NPNSFDGRGN YNLGLREQLI FPEITYDMVD
160 170 180
ALRGMDIAVV TTAETDEEAR ALLELLGFPF RK
Length:182
Mass (Da):21,044
Last modified:January 23, 2007 - v3
Checksum:iC3A8E0CFD884EEEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81658.1.
RefSeqiWP_011173706.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81658; AAS81658; TT_C1316.
KEGGitth:TT_C1316.
PATRICi23953039. VBITheThe54392_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81658.1.
RefSeqiWP_011173706.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71E1-182[»]
4V4JX-ray3.83E1-182[»]
4V63X-ray3.21BG/DG1-182[»]
4V67X-ray3.00BG/DG1-182[»]
4V7PX-ray3.62BF/CF2-182[»]
4V83X-ray3.50BF/DF2-182[»]
4V84X-ray3.40BF/DF2-182[»]
4V9JX-ray3.86BG/DG2-182[»]
4V9KX-ray3.50BG/DG2-182[»]
4V9LX-ray3.50BG/DG2-182[»]
4V9MX-ray4.00BG/DG2-182[»]
4V9NX-ray3.40BG/DG2-182[»]
4V9QX-ray3.40AG/CG2-182[»]
4W29X-ray3.80BG/DG2-182[»]
4XEJX-ray3.80AL05/BL052-182[»]
5J4DX-ray3.10H/MB1-182[»]
ProteinModelPortaliQ72I16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC1316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS81658; AAS81658; TT_C1316.
KEGGitth:TT_C1316.
PATRICi23953039. VBITheThe54392_1308.

Phylogenomic databases

eggNOGiENOG4105CW6. Bacteria.
COG0094. LUCA.
KOiK02931.
OMAiEQVMFHE.

Miscellaneous databases

EvolutionaryTraceiQ72I16.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
HAMAPiMF_01333_B. Ribosomal_L5_B. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR020930. Ribosomal_L5_bac-type.
IPR031309. Ribosomal_L5_C.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
[Graphical view]
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL5_THET2
AccessioniPrimary (citable) accession number: Q72I16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.