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Protein

50S ribosomal protein L22

Gene

rplV

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).UniRule annotation
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1338-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L22UniRule annotation
Gene namesi
Name:rplVUniRule annotation
Ordered Locus Names:TT_C1323
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11311350S ribosomal protein L22PRO_0000125248Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.UniRule annotation

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 127Combined sources
Helixi14 – 218Combined sources
Turni22 – 265Combined sources
Helixi29 – 3810Combined sources
Helixi42 – 6221Combined sources
Turni66 – 683Combined sources
Beta strandi70 – 734Combined sources
Beta strandi76 – 8712Combined sources
Helixi89 – 913Combined sources
Beta strandi93 – 10412Combined sources
Beta strandi106 – 1083Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71Q1-113[»]
4V4JX-ray3.83Q1-113[»]
4V63X-ray3.21BW/DW1-113[»]
4V67X-ray3.00BW/DW1-113[»]
4V7PX-ray3.62BS/CS1-112[»]
4V83X-ray3.50BS/DS1-112[»]
4V84X-ray3.40BS/DS1-112[»]
4V9JX-ray3.86BW/DW1-113[»]
4V9KX-ray3.50BW/DW1-113[»]
4V9LX-ray3.50BW/DW1-113[»]
4V9MX-ray4.00BW/DW1-113[»]
4V9NX-ray3.40BW/DW1-112[»]
4V9QX-ray3.40AS/CS1-112[»]
4W29X-ray3.80BW/DW1-113[»]
4XEJX-ray3.80AL22/BL221-112[»]
ProteinModelPortaliQ72I09.
SMRiQ72I09. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72I09.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L22P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0091.
KOiK02890.
OMAiGRAFRIN.
OrthoDBiEOG6V4GKB.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
HAMAPiMF_01331_B. Ribosomal_L22_B.
InterProiIPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.
TIGRFAMsiTIGR01044. rplV_bact. 1 hit.
PROSITEiPS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72I09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKAIARYV RISPRKVRLV VDLIRGKSLE EARNILRYTN KRGAYFVAKV
60 70 80 90 100
LESAAANAVN NHDMLEDRLY VKAAYVDEGP ALKRVLPRAR GRADIIKKRT
110
SHITVILGEK HGK
Length:113
Mass (Da):12,780
Last modified:July 5, 2004 - v1
Checksum:i11814D2DE644AF1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81665.1.
RefSeqiWP_011173710.1. NC_005835.1.
YP_005292.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81665; AAS81665; TT_C1323.
KEGGitth:TTC1323.
PATRICi23953053. VBITheThe54392_1315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81665.1.
RefSeqiWP_011173710.1. NC_005835.1.
YP_005292.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71Q1-113[»]
4V4JX-ray3.83Q1-113[»]
4V63X-ray3.21BW/DW1-113[»]
4V67X-ray3.00BW/DW1-113[»]
4V7PX-ray3.62BS/CS1-112[»]
4V83X-ray3.50BS/DS1-112[»]
4V84X-ray3.40BS/DS1-112[»]
4V9JX-ray3.86BW/DW1-113[»]
4V9KX-ray3.50BW/DW1-113[»]
4V9LX-ray3.50BW/DW1-113[»]
4V9MX-ray4.00BW/DW1-113[»]
4V9NX-ray3.40BW/DW1-112[»]
4V9QX-ray3.40AS/CS1-112[»]
4W29X-ray3.80BW/DW1-113[»]
4XEJX-ray3.80AL22/BL221-112[»]
ProteinModelPortaliQ72I09.
SMRiQ72I09. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS81665; AAS81665; TT_C1323.
KEGGitth:TTC1323.
PATRICi23953053. VBITheThe54392_1315.

Phylogenomic databases

eggNOGiCOG0091.
KOiK02890.
OMAiGRAFRIN.
OrthoDBiEOG6V4GKB.

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1338-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ72I09.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
HAMAPiMF_01331_B. Ribosomal_L22_B.
InterProiIPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.
TIGRFAMsiTIGR01044. rplV_bact. 1 hit.
PROSITEiPS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiRL22_THET2
AccessioniPrimary (citable) accession number: Q72I09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.