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Q72I07

- RL2_THET2

UniProt

Q72I07 - RL2_THET2

Protein

50S ribosomal protein L2

Gene

rplB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.UniRule annotation

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro
    3. transferase activity Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1340-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L2UniRule annotation
    Gene namesi
    Name:rplBUniRule annotation
    Ordered Locus Names:TT_C1325
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. large ribosomal subunit Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27627650S ribosomal protein L2PRO_0000237259Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation

    Protein-protein interaction databases

    STRINGi262724.TTC1325.

    Structurei

    Secondary structure

    1
    276
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 53
    Beta strandi9 – 157
    Beta strandi17 – 193
    Helixi21 – 233
    Beta strandi33 – 386
    Beta strandi45 – 473
    Beta strandi50 – 545
    Beta strandi61 – 633
    Turni67 – 726
    Beta strandi77 – 837
    Beta strandi88 – 903
    Beta strandi92 – 1009
    Beta strandi102 – 1065
    Beta strandi108 – 1103
    Beta strandi114 – 12310
    Beta strandi126 – 1283
    Beta strandi130 – 1323
    Turni133 – 1353
    Beta strandi141 – 1488
    Turni149 – 1513
    Beta strandi153 – 1553
    Beta strandi158 – 1603
    Beta strandi163 – 1697
    Beta strandi172 – 1765
    Turni178 – 1803
    Beta strandi182 – 1865
    Beta strandi190 – 1978
    Helixi199 – 2035
    Helixi209 – 2157
    Helixi223 – 2253
    Turni228 – 2303
    Turni232 – 2354
    Beta strandi237 – 2393
    Beta strandi243 – 2453
    Helixi265 – 2695
    Beta strandi270 – 2723

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VSAX-ray3.71B1-276[»]
    1VSPX-ray3.83B1-276[»]
    3D5BX-ray3.21D1-276[»]
    3D5DX-ray3.21D1-276[»]
    3F1FX-ray3.00D1-276[»]
    3F1HX-ray3.00D1-276[»]
    3MRZX-ray3.62C2-276[»]
    3MS1X-ray3.62C2-276[»]
    3PYOX-ray3.50C2-272[»]
    3PYRX-ray3.50C2-272[»]
    3PYTX-ray3.40C2-272[»]
    3PYVX-ray3.40C2-272[»]
    4KBUX-ray3.86D2-276[»]
    4KBWX-ray3.86D2-276[»]
    4KCZX-ray3.50D2-276[»]
    4KD2X-ray3.50D2-276[»]
    4KD9X-ray3.50D2-276[»]
    4KDBX-ray3.50D2-276[»]
    4KDHX-ray4.00D2-276[»]
    4KDKX-ray4.00D2-276[»]
    4KFIX-ray3.40D2-272[»]
    4KFLX-ray3.40D2-272[»]
    4L6JX-ray3.40D2-272[»]
    4L6LX-ray3.40D2-272[»]
    ProteinModelPortaliQ72I07.
    SMRiQ72I07. Positions 2-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ72I07.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L2P family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0090.
    KOiK02886.
    OMAiVYIRINE.
    OrthoDBiEOG6TR0J1.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    4.10.950.10. 1 hit.
    HAMAPiMF_01320_B. Ribosomal_L2_B.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR022666. Rbsml_prot_L2_RNA-bd_dom.
    IPR014722. Rib_L2_dom2.
    IPR002171. Ribosomal_L2.
    IPR005880. Ribosomal_L2_bac/org-type.
    IPR022669. Ribosomal_L2_C.
    IPR022671. Ribosomal_L2_CS.
    IPR014726. Ribosomal_L2_dom3.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR13691. PTHR13691. 1 hit.
    PTHR13691:SF5. PTHR13691:SF5. 1 hit.
    PfamiPF00181. Ribosomal_L2. 1 hit.
    PF03947. Ribosomal_L2_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
    SUPFAMiSSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR01171. rplB_bact. 1 hit.
    PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q72I07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVKKFKPYT PSRRFMTVAD FSEITKTEPE KSLVKPLKKT GGRNNQGRIT    50
    VRFRGGGHKR LYRIIDFKRW DKVGIPAKVA AIEYDPNRSA RIALLHYVDG 100
    EKRYIIAPDG LQVGQQVVAG PDAPIQVGNA LPLRFIPVGT VVHAVELEPK 150
    KGAKLARAAG TSAQIQGREG DYVILRLPSG ELRKVHGECY ATVGAVGNAD 200
    HKNIVLGKAG RSRWLGRRPH VRGAAMNPVD HPHGGGEGRA PRGRPPASPW 250
    GWQTKGLKTR KRRKPSSRFI IARRKK 276
    Length:276
    Mass (Da):30,468
    Last modified:July 5, 2004 - v1
    Checksum:i7CF40C2BD586349B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81667.1.
    RefSeqiYP_005294.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS81667; AAS81667; TT_C1325.
    GeneIDi2775711.
    KEGGitth:TTC1325.
    PATRICi23953057. VBITheThe54392_1317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81667.1 .
    RefSeqi YP_005294.1. NC_005835.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VSA X-ray 3.71 B 1-276 [» ]
    1VSP X-ray 3.83 B 1-276 [» ]
    3D5B X-ray 3.21 D 1-276 [» ]
    3D5D X-ray 3.21 D 1-276 [» ]
    3F1F X-ray 3.00 D 1-276 [» ]
    3F1H X-ray 3.00 D 1-276 [» ]
    3MRZ X-ray 3.62 C 2-276 [» ]
    3MS1 X-ray 3.62 C 2-276 [» ]
    3PYO X-ray 3.50 C 2-272 [» ]
    3PYR X-ray 3.50 C 2-272 [» ]
    3PYT X-ray 3.40 C 2-272 [» ]
    3PYV X-ray 3.40 C 2-272 [» ]
    4KBU X-ray 3.86 D 2-276 [» ]
    4KBW X-ray 3.86 D 2-276 [» ]
    4KCZ X-ray 3.50 D 2-276 [» ]
    4KD2 X-ray 3.50 D 2-276 [» ]
    4KD9 X-ray 3.50 D 2-276 [» ]
    4KDB X-ray 3.50 D 2-276 [» ]
    4KDH X-ray 4.00 D 2-276 [» ]
    4KDK X-ray 4.00 D 2-276 [» ]
    4KFI X-ray 3.40 D 2-272 [» ]
    4KFL X-ray 3.40 D 2-272 [» ]
    4L6J X-ray 3.40 D 2-272 [» ]
    4L6L X-ray 3.40 D 2-272 [» ]
    ProteinModelPortali Q72I07.
    SMRi Q72I07. Positions 2-273.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TTC1325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS81667 ; AAS81667 ; TT_C1325 .
    GeneIDi 2775711.
    KEGGi tth:TTC1325.
    PATRICi 23953057. VBITheThe54392_1317.

    Phylogenomic databases

    eggNOGi COG0090.
    KOi K02886.
    OMAi VYIRINE.
    OrthoDBi EOG6TR0J1.

    Enzyme and pathway databases

    BioCyci TTHE262724:GCAT-1340-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q72I07.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    4.10.950.10. 1 hit.
    HAMAPi MF_01320_B. Ribosomal_L2_B.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR022666. Rbsml_prot_L2_RNA-bd_dom.
    IPR014722. Rib_L2_dom2.
    IPR002171. Ribosomal_L2.
    IPR005880. Ribosomal_L2_bac/org-type.
    IPR022669. Ribosomal_L2_C.
    IPR022671. Ribosomal_L2_CS.
    IPR014726. Ribosomal_L2_dom3.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR13691. PTHR13691. 1 hit.
    PTHR13691:SF5. PTHR13691:SF5. 1 hit.
    Pfami PF00181. Ribosomal_L2. 1 hit.
    PF03947. Ribosomal_L2_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002158. Ribosomal_L2. 1 hit.
    SUPFAMi SSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR01171. rplB_bact. 1 hit.
    PROSITEi PS00467. RIBOSOMAL_L2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.

    Entry informationi

    Entry nameiRL2_THET2
    AccessioniPrimary (citable) accession number: Q72I07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3