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Q72I07

- RL2_THET2

UniProt

Q72I07 - RL2_THET2

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Protein

50S ribosomal protein L2

Gene

rplB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. transferase activity Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1340-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L2UniRule annotation
Gene namesi
Name:rplBUniRule annotation
Ordered Locus Names:TT_C1325
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27627650S ribosomal protein L2PRO_0000237259Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1325.

Structurei

Secondary structure

1
276
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53
Beta strandi9 – 157
Beta strandi17 – 193
Helixi21 – 233
Beta strandi33 – 386
Beta strandi45 – 473
Beta strandi50 – 545
Beta strandi61 – 633
Turni67 – 726
Beta strandi77 – 837
Beta strandi88 – 903
Beta strandi92 – 1009
Beta strandi102 – 1065
Beta strandi108 – 1103
Beta strandi114 – 12310
Beta strandi126 – 1283
Beta strandi130 – 1323
Turni133 – 1353
Beta strandi141 – 1488
Turni149 – 1513
Beta strandi153 – 1553
Beta strandi158 – 1603
Beta strandi163 – 1697
Beta strandi172 – 1765
Turni178 – 1803
Beta strandi182 – 1865
Beta strandi190 – 1978
Helixi199 – 2035
Helixi209 – 2157
Helixi223 – 2253
Turni228 – 2303
Turni232 – 2354
Beta strandi237 – 2393
Beta strandi243 – 2453
Helixi265 – 2695
Beta strandi270 – 2723

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VSAX-ray3.71B1-276[»]
1VSPX-ray3.83B1-276[»]
3D5BX-ray3.21D1-276[»]
3D5DX-ray3.21D1-276[»]
3F1FX-ray3.00D1-276[»]
3F1HX-ray3.00D1-276[»]
3MRZX-ray3.62C2-276[»]
3MS1X-ray3.62C2-276[»]
3PYOX-ray3.50C2-272[»]
3PYRX-ray3.50C2-272[»]
3PYTX-ray3.40C2-272[»]
3PYVX-ray3.40C2-272[»]
4KBUX-ray3.86D2-276[»]
4KBWX-ray3.86D2-276[»]
4KCZX-ray3.50D2-276[»]
4KD2X-ray3.50D2-276[»]
4KD9X-ray3.50D2-276[»]
4KDBX-ray3.50D2-276[»]
4KDHX-ray4.00D2-276[»]
4KDKX-ray4.00D2-276[»]
4KFIX-ray3.40D2-272[»]
4KFLX-ray3.40D2-272[»]
4L6JX-ray3.40D2-272[»]
4L6LX-ray3.40D2-272[»]
ProteinModelPortaliQ72I07.
SMRiQ72I07. Positions 2-273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72I07.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L2P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0090.
KOiK02886.
OMAiVYIRINE.
OrthoDBiEOG6TR0J1.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
4.10.950.10. 1 hit.
HAMAPiMF_01320_B. Ribosomal_L2_B.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR005880. Ribosomal_L2_bac/org-type.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PTHR13691:SF5. PTHR13691:SF5. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR01171. rplB_bact. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72I07 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVKKFKPYT PSRRFMTVAD FSEITKTEPE KSLVKPLKKT GGRNNQGRIT
60 70 80 90 100
VRFRGGGHKR LYRIIDFKRW DKVGIPAKVA AIEYDPNRSA RIALLHYVDG
110 120 130 140 150
EKRYIIAPDG LQVGQQVVAG PDAPIQVGNA LPLRFIPVGT VVHAVELEPK
160 170 180 190 200
KGAKLARAAG TSAQIQGREG DYVILRLPSG ELRKVHGECY ATVGAVGNAD
210 220 230 240 250
HKNIVLGKAG RSRWLGRRPH VRGAAMNPVD HPHGGGEGRA PRGRPPASPW
260 270
GWQTKGLKTR KRRKPSSRFI IARRKK
Length:276
Mass (Da):30,468
Last modified:July 5, 2004 - v1
Checksum:i7CF40C2BD586349B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81667.1.
RefSeqiYP_005294.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81667; AAS81667; TT_C1325.
GeneIDi2775711.
KEGGitth:TTC1325.
PATRICi23953057. VBITheThe54392_1317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81667.1 .
RefSeqi YP_005294.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VSA X-ray 3.71 B 1-276 [» ]
1VSP X-ray 3.83 B 1-276 [» ]
3D5B X-ray 3.21 D 1-276 [» ]
3D5D X-ray 3.21 D 1-276 [» ]
3F1F X-ray 3.00 D 1-276 [» ]
3F1H X-ray 3.00 D 1-276 [» ]
3MRZ X-ray 3.62 C 2-276 [» ]
3MS1 X-ray 3.62 C 2-276 [» ]
3PYO X-ray 3.50 C 2-272 [» ]
3PYR X-ray 3.50 C 2-272 [» ]
3PYT X-ray 3.40 C 2-272 [» ]
3PYV X-ray 3.40 C 2-272 [» ]
4KBU X-ray 3.86 D 2-276 [» ]
4KBW X-ray 3.86 D 2-276 [» ]
4KCZ X-ray 3.50 D 2-276 [» ]
4KD2 X-ray 3.50 D 2-276 [» ]
4KD9 X-ray 3.50 D 2-276 [» ]
4KDB X-ray 3.50 D 2-276 [» ]
4KDH X-ray 4.00 D 2-276 [» ]
4KDK X-ray 4.00 D 2-276 [» ]
4KFI X-ray 3.40 D 2-272 [» ]
4KFL X-ray 3.40 D 2-272 [» ]
4L6J X-ray 3.40 D 2-272 [» ]
4L6L X-ray 3.40 D 2-272 [» ]
ProteinModelPortali Q72I07.
SMRi Q72I07. Positions 2-273.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS81667 ; AAS81667 ; TT_C1325 .
GeneIDi 2775711.
KEGGi tth:TTC1325.
PATRICi 23953057. VBITheThe54392_1317.

Phylogenomic databases

eggNOGi COG0090.
KOi K02886.
OMAi VYIRINE.
OrthoDBi EOG6TR0J1.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1340-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q72I07.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
4.10.950.10. 1 hit.
HAMAPi MF_01320_B. Ribosomal_L2_B.
InterProi IPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR005880. Ribosomal_L2_bac/org-type.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR13691. PTHR13691. 1 hit.
PTHR13691:SF5. PTHR13691:SF5. 1 hit.
Pfami PF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF002158. Ribosomal_L2. 1 hit.
SUPFAMi SSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR01171. rplB_bact. 1 hit.
PROSITEi PS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiRL2_THET2
AccessioniPrimary (citable) accession number: Q72I07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3