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Protein

50S ribosomal protein L2

Gene

rplB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L2UniRule annotation
Gene namesi
Name:rplBUniRule annotation
Ordered Locus Names:TT_C1325
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002372591 – 27650S ribosomal protein L2Add BLAST276

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1325.

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi9 – 15Combined sources7
Beta strandi17 – 19Combined sources3
Helixi21 – 23Combined sources3
Beta strandi33 – 38Combined sources6
Beta strandi45 – 47Combined sources3
Beta strandi50 – 54Combined sources5
Beta strandi61 – 63Combined sources3
Turni67 – 72Combined sources6
Beta strandi77 – 83Combined sources7
Beta strandi88 – 90Combined sources3
Beta strandi92 – 100Combined sources9
Beta strandi102 – 106Combined sources5
Beta strandi108 – 110Combined sources3
Beta strandi114 – 123Combined sources10
Beta strandi126 – 128Combined sources3
Beta strandi130 – 132Combined sources3
Turni133 – 135Combined sources3
Beta strandi141 – 148Combined sources8
Turni149 – 151Combined sources3
Beta strandi153 – 155Combined sources3
Beta strandi158 – 160Combined sources3
Beta strandi163 – 169Combined sources7
Beta strandi172 – 176Combined sources5
Turni178 – 180Combined sources3
Beta strandi182 – 186Combined sources5
Beta strandi190 – 197Combined sources8
Helixi199 – 203Combined sources5
Helixi209 – 215Combined sources7
Helixi223 – 225Combined sources3
Turni228 – 230Combined sources3
Turni232 – 235Combined sources4
Beta strandi237 – 239Combined sources3
Beta strandi243 – 245Combined sources3
Helixi265 – 269Combined sources5
Beta strandi270 – 272Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71B1-276[»]
4V4JX-ray3.83B1-276[»]
4V63X-ray3.21BD/DD1-276[»]
4V67X-ray3.00BD/DD1-276[»]
4V7PX-ray3.62BC/CC2-276[»]
4V83X-ray3.50BC/DC2-272[»]
4V84X-ray3.40BC/DC2-272[»]
4V9JX-ray3.86BD/DD2-276[»]
4V9KX-ray3.50BD/DD2-276[»]
4V9LX-ray3.50BD/DD2-276[»]
4V9MX-ray4.00BD/DD2-276[»]
4V9NX-ray3.40BD/DD2-272[»]
4V9QX-ray3.40AD/CD2-272[»]
4W29X-ray3.80BD/DD2-276[»]
4XEJX-ray3.80AL02/BL022-272[»]
5J4DX-ray3.10E/JB2-276[»]
ProteinModelPortaliQ72I07.
SMRiQ72I07.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72I07.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L2P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFD. Bacteria.
COG0090. LUCA.
KOiK02886.
OMAiPIKAGNN.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
4.10.950.10. 1 hit.
HAMAPiMF_01320_B. Ribosomal_L2_B. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR005880. Ribosomal_L2_bac/org-type.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PTHR13691:SF5. PTHR13691:SF5. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SMARTiSM01383. Ribosomal_L2. 1 hit.
SM01382. Ribosomal_L2_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR01171. rplB_bact. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72I07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKKFKPYT PSRRFMTVAD FSEITKTEPE KSLVKPLKKT GGRNNQGRIT
60 70 80 90 100
VRFRGGGHKR LYRIIDFKRW DKVGIPAKVA AIEYDPNRSA RIALLHYVDG
110 120 130 140 150
EKRYIIAPDG LQVGQQVVAG PDAPIQVGNA LPLRFIPVGT VVHAVELEPK
160 170 180 190 200
KGAKLARAAG TSAQIQGREG DYVILRLPSG ELRKVHGECY ATVGAVGNAD
210 220 230 240 250
HKNIVLGKAG RSRWLGRRPH VRGAAMNPVD HPHGGGEGRA PRGRPPASPW
260 270
GWQTKGLKTR KRRKPSSRFI IARRKK
Length:276
Mass (Da):30,468
Last modified:July 5, 2004 - v1
Checksum:i7CF40C2BD586349B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81667.1.
RefSeqiWP_011173712.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81667; AAS81667; TT_C1325.
KEGGitth:TT_C1325.
PATRICi23953057. VBITheThe54392_1317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81667.1.
RefSeqiWP_011173712.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71B1-276[»]
4V4JX-ray3.83B1-276[»]
4V63X-ray3.21BD/DD1-276[»]
4V67X-ray3.00BD/DD1-276[»]
4V7PX-ray3.62BC/CC2-276[»]
4V83X-ray3.50BC/DC2-272[»]
4V84X-ray3.40BC/DC2-272[»]
4V9JX-ray3.86BD/DD2-276[»]
4V9KX-ray3.50BD/DD2-276[»]
4V9LX-ray3.50BD/DD2-276[»]
4V9MX-ray4.00BD/DD2-276[»]
4V9NX-ray3.40BD/DD2-272[»]
4V9QX-ray3.40AD/CD2-272[»]
4W29X-ray3.80BD/DD2-276[»]
4XEJX-ray3.80AL02/BL022-272[»]
5J4DX-ray3.10E/JB2-276[»]
ProteinModelPortaliQ72I07.
SMRiQ72I07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC1325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS81667; AAS81667; TT_C1325.
KEGGitth:TT_C1325.
PATRICi23953057. VBITheThe54392_1317.

Phylogenomic databases

eggNOGiENOG4105CFD. Bacteria.
COG0090. LUCA.
KOiK02886.
OMAiPIKAGNN.

Miscellaneous databases

EvolutionaryTraceiQ72I07.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
4.10.950.10. 1 hit.
HAMAPiMF_01320_B. Ribosomal_L2_B. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR005880. Ribosomal_L2_bac/org-type.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PTHR13691:SF5. PTHR13691:SF5. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SMARTiSM01383. Ribosomal_L2. 1 hit.
SM01382. Ribosomal_L2_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR01171. rplB_bact. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL2_THET2
AccessioniPrimary (citable) accession number: Q72I07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.