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Protein

50S ribosomal protein L2

Gene

rplB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. transferase activity Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1340-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L2UniRule annotation
Gene namesi
Name:rplBUniRule annotation
Ordered Locus Names:TT_C1325
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27627650S ribosomal protein L2PRO_0000237259Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1325.

Structurei

Secondary structure

1
276
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi9 – 157Combined sources
Beta strandi17 – 193Combined sources
Helixi21 – 233Combined sources
Beta strandi33 – 386Combined sources
Beta strandi45 – 473Combined sources
Beta strandi50 – 545Combined sources
Beta strandi61 – 633Combined sources
Turni67 – 726Combined sources
Beta strandi77 – 837Combined sources
Beta strandi88 – 903Combined sources
Beta strandi92 – 1009Combined sources
Beta strandi102 – 1065Combined sources
Beta strandi108 – 1103Combined sources
Beta strandi114 – 12310Combined sources
Beta strandi126 – 1283Combined sources
Beta strandi130 – 1323Combined sources
Turni133 – 1353Combined sources
Beta strandi141 – 1488Combined sources
Turni149 – 1513Combined sources
Beta strandi153 – 1553Combined sources
Beta strandi158 – 1603Combined sources
Beta strandi163 – 1697Combined sources
Beta strandi172 – 1765Combined sources
Turni178 – 1803Combined sources
Beta strandi182 – 1865Combined sources
Beta strandi190 – 1978Combined sources
Helixi199 – 2035Combined sources
Helixi209 – 2157Combined sources
Helixi223 – 2253Combined sources
Turni228 – 2303Combined sources
Turni232 – 2354Combined sources
Beta strandi237 – 2393Combined sources
Beta strandi243 – 2453Combined sources
Helixi265 – 2695Combined sources
Beta strandi270 – 2723Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KDKX-ray4.00D2-276[»]
4L6JX-ray3.40D2-272[»]
4L6LX-ray3.40D2-272[»]
4V4IX-ray3.71B1-276[»]
4V4JX-ray3.83B1-276[»]
4V63X-ray3.21D1-276[»]
4V67X-ray3.00D1-276[»]
4V7PX-ray3.62C2-276[»]
4V83X-ray3.50C2-272[»]
4V84X-ray3.40C2-272[»]
4V9JX-ray3.86D2-276[»]
4V9KX-ray3.50D2-276[»]
4V9LX-ray3.50D2-276[»]
4V9MX-ray4.00D2-276[»]
4V9NX-ray3.40D2-272[»]
4W29X-ray3.80D2-276[»]
ProteinModelPortaliQ72I07.
SMRiQ72I07. Positions 2-273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72I07.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L2P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0090.
KOiK02886.
OMAiNNLPIRN.
OrthoDBiEOG6TR0J1.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
4.10.950.10. 1 hit.
HAMAPiMF_01320_B. Ribosomal_L2_B.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR005880. Ribosomal_L2_bac/org-type.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PTHR13691:SF5. PTHR13691:SF5. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR01171. rplB_bact. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72I07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVKKFKPYT PSRRFMTVAD FSEITKTEPE KSLVKPLKKT GGRNNQGRIT
60 70 80 90 100
VRFRGGGHKR LYRIIDFKRW DKVGIPAKVA AIEYDPNRSA RIALLHYVDG
110 120 130 140 150
EKRYIIAPDG LQVGQQVVAG PDAPIQVGNA LPLRFIPVGT VVHAVELEPK
160 170 180 190 200
KGAKLARAAG TSAQIQGREG DYVILRLPSG ELRKVHGECY ATVGAVGNAD
210 220 230 240 250
HKNIVLGKAG RSRWLGRRPH VRGAAMNPVD HPHGGGEGRA PRGRPPASPW
260 270
GWQTKGLKTR KRRKPSSRFI IARRKK
Length:276
Mass (Da):30,468
Last modified:July 5, 2004 - v1
Checksum:i7CF40C2BD586349B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81667.1.
RefSeqiWP_011173712.1. NC_005835.1.
YP_005294.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81667; AAS81667; TT_C1325.
GeneIDi2775711.
KEGGitth:TTC1325.
PATRICi23953057. VBITheThe54392_1317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81667.1.
RefSeqiWP_011173712.1. NC_005835.1.
YP_005294.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KDKX-ray4.00D2-276[»]
4L6JX-ray3.40D2-272[»]
4L6LX-ray3.40D2-272[»]
4V4IX-ray3.71B1-276[»]
4V4JX-ray3.83B1-276[»]
4V63X-ray3.21D1-276[»]
4V67X-ray3.00D1-276[»]
4V7PX-ray3.62C2-276[»]
4V83X-ray3.50C2-272[»]
4V84X-ray3.40C2-272[»]
4V9JX-ray3.86D2-276[»]
4V9KX-ray3.50D2-276[»]
4V9LX-ray3.50D2-276[»]
4V9MX-ray4.00D2-276[»]
4V9NX-ray3.40D2-272[»]
4W29X-ray3.80D2-276[»]
ProteinModelPortaliQ72I07.
SMRiQ72I07. Positions 2-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC1325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS81667; AAS81667; TT_C1325.
GeneIDi2775711.
KEGGitth:TTC1325.
PATRICi23953057. VBITheThe54392_1317.

Phylogenomic databases

eggNOGiCOG0090.
KOiK02886.
OMAiNNLPIRN.
OrthoDBiEOG6TR0J1.

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1340-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ72I07.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
4.10.950.10. 1 hit.
HAMAPiMF_01320_B. Ribosomal_L2_B.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR005880. Ribosomal_L2_bac/org-type.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PTHR13691:SF5. PTHR13691:SF5. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR01171. rplB_bact. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiRL2_THET2
AccessioniPrimary (citable) accession number: Q72I07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.