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Protein

50S ribosomal protein L4

Gene

rplD

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.UniRule annotation
Forms part of the polypeptide exit tunnel.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L4UniRule annotation
Gene namesi
Name:rplDUniRule annotation
Ordered Locus Names:TT_C1327
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002424551 – 20550S ribosomal protein L4Add BLAST205

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.

Protein-protein interaction databases

STRINGi262724.TTC1327.

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Beta strandi13 – 15Combined sources3
Helixi25 – 38Combined sources14
Beta strandi48 – 51Combined sources4
Beta strandi52 – 54Combined sources3
Beta strandi62 – 65Combined sources4
Beta strandi73 – 75Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi83 – 85Combined sources3
Helixi98 – 115Combined sources18
Beta strandi118 – 121Combined sources4
Turni125 – 129Combined sources5
Helixi131 – 139Combined sources9
Turni140 – 142Combined sources3
Beta strandi145 – 147Combined sources3
Beta strandi149 – 152Combined sources4
Helixi156 – 164Combined sources9
Beta strandi168 – 171Combined sources4
Helixi173 – 175Combined sources3
Helixi178 – 181Combined sources4
Beta strandi184 – 190Combined sources7
Helixi191 – 200Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71D1-205[»]
4V4JX-ray3.83D1-205[»]
4V63X-ray3.21BF/DF1-205[»]
4V67X-ray3.00BF/DF1-205[»]
4V7PX-ray3.62BE/CE1-205[»]
4V83X-ray3.50BE/DE1-202[»]
4V84X-ray3.40BE/DE1-202[»]
4V9JX-ray3.86BF/DF1-203[»]
4V9KX-ray3.50BF/DF1-203[»]
4V9LX-ray3.50BF/DF1-203[»]
4V9MX-ray4.00BF/DF1-203[»]
4V9NX-ray3.40BF/DF1-202[»]
4V9QX-ray3.40AF/CF1-202[»]
4W29X-ray3.80BF/DF1-203[»]
4XEJX-ray3.80AL04/BL041-202[»]
5J4DX-ray3.10G/LB1-205[»]
ProteinModelPortaliQ72I05.
SMRiQ72I05.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72I05.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L4P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106U5A. Bacteria.
COG0088. LUCA.
KOiK02926.
OMAiAHNIVIS.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
HAMAPiMF_01328_B. Ribosomal_L4_B. 1 hit.
InterProiIPR002136. Ribosomal_L4/L1e.
IPR023574. Ribosomal_L4_dom.
IPR013005. Ribosomal_uL4/L1e.
[Graphical view]
PANTHERiPTHR10746. PTHR10746. 1 hit.
PfamiPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
TIGRFAMsiTIGR03953. rplD_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72I05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQIPVLSPS GRRELAADLP AEINPHLLWE VVRWQLAKRR RGTASTKTRG
60 70 80 90 100
EVAYSGRKIW PQKHTGRARH GDIGAPIFVG GGVVFGPKPR DYSYTLPKKV
110 120 130 140 150
RKKGLAMAVA DRAREGKLLL VEAFAGVNGK TKEFLAWAKE AGLDGSESVL
160 170 180 190 200
LVTGNELVRR AARNLPWVVT LAPEGLNVYD IVRTERLVMD LDAWEVFQNR

IGGEA
Length:205
Mass (Da):22,708
Last modified:July 5, 2004 - v1
Checksum:iFC50A700F8CBC324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81669.1.

Genome annotation databases

EnsemblBacteriaiAAS81669; AAS81669; TT_C1327.
KEGGitth:TT_C1327.
PATRICi23953061. VBITheThe54392_1319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81669.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71D1-205[»]
4V4JX-ray3.83D1-205[»]
4V63X-ray3.21BF/DF1-205[»]
4V67X-ray3.00BF/DF1-205[»]
4V7PX-ray3.62BE/CE1-205[»]
4V83X-ray3.50BE/DE1-202[»]
4V84X-ray3.40BE/DE1-202[»]
4V9JX-ray3.86BF/DF1-203[»]
4V9KX-ray3.50BF/DF1-203[»]
4V9LX-ray3.50BF/DF1-203[»]
4V9MX-ray4.00BF/DF1-203[»]
4V9NX-ray3.40BF/DF1-202[»]
4V9QX-ray3.40AF/CF1-202[»]
4W29X-ray3.80BF/DF1-203[»]
4XEJX-ray3.80AL04/BL041-202[»]
5J4DX-ray3.10G/LB1-205[»]
ProteinModelPortaliQ72I05.
SMRiQ72I05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC1327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS81669; AAS81669; TT_C1327.
KEGGitth:TT_C1327.
PATRICi23953061. VBITheThe54392_1319.

Phylogenomic databases

eggNOGiENOG4106U5A. Bacteria.
COG0088. LUCA.
KOiK02926.
OMAiAHNIVIS.

Miscellaneous databases

EvolutionaryTraceiQ72I05.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
HAMAPiMF_01328_B. Ribosomal_L4_B. 1 hit.
InterProiIPR002136. Ribosomal_L4/L1e.
IPR023574. Ribosomal_L4_dom.
IPR013005. Ribosomal_uL4/L1e.
[Graphical view]
PANTHERiPTHR10746. PTHR10746. 1 hit.
PfamiPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
TIGRFAMsiTIGR03953. rplD_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL4_THET2
AccessioniPrimary (citable) accession number: Q72I05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.