Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q72I01

- EFG_THET2

UniProt

Q72I01 - EFG_THET2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Elongation factor G

Gene

fusA

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi83 – 875GTPUniRule annotation
Nucleotide bindingi137 – 1404GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor GUniRule annotation
Short name:
EF-GUniRule annotation
Gene namesi
Name:fusAUniRule annotation
Ordered Locus Names:TT_C1331
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Elongation factor GPRO_0000091247Add
BLAST

Structurei

Secondary structure

1
691
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 157
Beta strandi20 – 223
Helixi25 – 339
Turni56 – 616
Beta strandi66 – 683
Beta strandi73 – 764
Beta strandi77 – 826
Helixi93 – 986
Beta strandi104 – 1074
Turni111 – 1144
Helixi116 – 1183
Helixi121 – 1255
Beta strandi132 – 1354
Beta strandi139 – 1435
Helixi147 – 1537
Turni154 – 1574
Beta strandi165 – 1684
Turni171 – 1733
Beta strandi177 – 1826
Beta strandi184 – 1874
Beta strandi190 – 1923
Beta strandi203 – 2053
Helixi206 – 21914
Turni220 – 2234
Helixi227 – 2326
Helixi239 – 25113
Turni263 – 2664
Helixi269 – 27911
Turni283 – 2853
Beta strandi290 – 2923
Beta strandi294 – 2963
Beta strandi298 – 3003
Beta strandi310 – 3178
Turni320 – 3223
Beta strandi324 – 3296
Beta strandi340 – 3467
Beta strandi351 – 3599
Beta strandi362 – 3698
Beta strandi375 – 3795
Beta strandi388 – 3947
Beta strandi409 – 4135
Turni416 – 4205
Helixi421 – 43414
Beta strandi439 – 4424
Beta strandi444 – 45613
Helixi457 – 46913
Beta strandi484 – 4863
Beta strandi491 – 4955
Beta strandi509 – 5146
Beta strandi530 – 5345
Turni540 – 5445
Helixi545 – 5506
Turni554 – 5563
Beta strandi569 – 5713
Beta strandi574 – 5763
Helixi579 – 59517
Beta strandi601 – 6088
Helixi615 – 62612
Beta strandi627 – 6293
Beta strandi638 – 6425
Beta strandi645 – 6473
Turni650 – 6545
Helixi656 – 6627
Beta strandi663 – 6653
Beta strandi671 – 6777
Helixi682 – 6865

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KBTX-ray3.86Y4-690[»]
4KBVX-ray3.86Y4-690[»]
4KCYX-ray3.50Y4-690[»]
4KD0X-ray3.50Y4-690[»]
4KD8X-ray3.50Y4-690[»]
4KDAX-ray3.50Y4-690[»]
4KDGX-ray4.00Y4-690[»]
4KDJX-ray4.00Y4-690[»]
ProteinModelPortaliQ72I01.
SMRiQ72I01. Positions 4-689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 284275tr-type GAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0480.
KOiK02355.
OMAiFETSMAN.
OrthoDBiEOG6X6RBF.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72I01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVKVEYDLK RLRNIGIAAH IDAGKTTTTE RILYYTGRIH KIGEVHEGAA
60 70 80 90 100
TMDFMEQERE RGITITAAVT TCFWKDHRIN IIDTPGHVDF TIEVERSMRV
110 120 130 140 150
LDGAIVVFDS SQGVEPQSET VWRQAEKYHV PRIAFANKMD KTGADLWLVI
160 170 180 190 200
RTMQERLGAR PVVMQLPIGR EDTFSGIIDV LRMKAYTYGN DLGTDIREIP
210 220 230 240 250
IPEEYLDQAR EYHEKLVEVA ADFDEHIMLK YLEGEEPTEE ELVAAIRKGT
260 270 280 290 300
IDLKITPVFL GSALKNKGVQ LLLDAVVDYL PSPLDIPPIK GTTPEGEVVE
310 320 330 340 350
IHPDPNGPLA ALAFKIMADP YVGRLTFIRV YSGTLTSGSY VYNTTKGRKE
360 370 380 390 400
RVARLLRMHA NHREEVEELK AGDLGAVVGL KETITGDTLV GEDAPRVILE
410 420 430 440 450
SIEVPEPVID VAIEPKTKAD QEKLSQALAR LAEEDPTFRV STHPETGQTI
460 470 480 490 500
ISGMGELHLE IIVDRLKREF KVDANVGKPQ VAYRETITKP VDVEGKFIRQ
510 520 530 540 550
TGGRGQYGHV KIKVEPLPRG SGFEFVNAIV GGVIPKEYIP AVQKGIEEAM
560 570 580 590 600
QSGPLIGFPV VDIKVTLYDG SYHEVDSSEM AFKIAGSMAI KEAVQKGDPV
610 620 630 640 650
ILEPIMRVEV TTPEEYMGDV IGDLNARRGQ ILGMEPRGNA QVIRAFVPLA
660 670 680 690
EMFGYATDLR SKTQGRGSFV MFFDHYQEVP KQVQEKLIKG Q
Length:691
Mass (Da):76,911
Last modified:July 5, 2004 - v1
Checksum:i109D07619C9EEC81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81673.1.
RefSeqiWP_011173716.1. NC_005835.1.
YP_005300.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81673; AAS81673; TT_C1331.
GeneIDi2775872.
KEGGitth:TTC1331.
PATRICi23953069. VBITheThe54392_1323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81673.1 .
RefSeqi WP_011173716.1. NC_005835.1.
YP_005300.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KBT X-ray 3.86 Y 4-690 [» ]
4KBV X-ray 3.86 Y 4-690 [» ]
4KCY X-ray 3.50 Y 4-690 [» ]
4KD0 X-ray 3.50 Y 4-690 [» ]
4KD8 X-ray 3.50 Y 4-690 [» ]
4KDA X-ray 3.50 Y 4-690 [» ]
4KDG X-ray 4.00 Y 4-690 [» ]
4KDJ X-ray 4.00 Y 4-690 [» ]
ProteinModelPortali Q72I01.
SMRi Q72I01. Positions 4-689.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS81673 ; AAS81673 ; TT_C1331 .
GeneIDi 2775872.
KEGGi tth:TTC1331.
PATRICi 23953069. VBITheThe54392_1323.

Phylogenomic databases

eggNOGi COG0480.
KOi K02355.
OMAi FETSMAN.
OrthoDBi EOG6X6RBF.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1346-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00054_B. EF_G_EF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
Pfami PF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SMARTi SM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsi TIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiEFG_THET2
AccessioniPrimary (citable) accession number: Q72I01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3