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Q72I01

- EFG_THET2

UniProt

Q72I01 - EFG_THET2

Protein

Elongation factor G

Gene

fusA

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi83 – 875GTPUniRule annotation
    Nucleotide bindingi137 – 1404GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1346-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor GUniRule annotation
    Short name:
    EF-GUniRule annotation
    Gene namesi
    Name:fusAUniRule annotation
    Ordered Locus Names:TT_C1331
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 691691Elongation factor GPRO_0000091247Add
    BLAST

    Structurei

    Secondary structure

    1
    691
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 157
    Beta strandi20 – 223
    Helixi25 – 339
    Turni56 – 616
    Beta strandi66 – 683
    Beta strandi73 – 764
    Beta strandi77 – 826
    Helixi93 – 986
    Beta strandi104 – 1074
    Turni111 – 1144
    Helixi116 – 1183
    Helixi121 – 1255
    Beta strandi132 – 1354
    Beta strandi139 – 1435
    Helixi147 – 1537
    Turni154 – 1574
    Beta strandi165 – 1684
    Turni171 – 1733
    Beta strandi177 – 1826
    Beta strandi184 – 1874
    Beta strandi190 – 1923
    Beta strandi203 – 2053
    Helixi206 – 21914
    Turni220 – 2234
    Helixi227 – 2326
    Helixi239 – 25113
    Turni263 – 2664
    Helixi269 – 27911
    Turni283 – 2853
    Beta strandi290 – 2923
    Beta strandi294 – 2963
    Beta strandi298 – 3003
    Beta strandi310 – 3178
    Turni320 – 3223
    Beta strandi324 – 3296
    Beta strandi340 – 3467
    Beta strandi351 – 3599
    Beta strandi362 – 3698
    Beta strandi375 – 3795
    Beta strandi388 – 3947
    Beta strandi409 – 4135
    Turni416 – 4205
    Helixi421 – 43414
    Beta strandi439 – 4424
    Beta strandi444 – 45613
    Helixi457 – 46913
    Beta strandi484 – 4863
    Beta strandi491 – 4955
    Beta strandi509 – 5146
    Beta strandi530 – 5345
    Turni540 – 5445
    Helixi545 – 5506
    Turni554 – 5563
    Beta strandi569 – 5713
    Beta strandi574 – 5763
    Helixi579 – 59517
    Beta strandi601 – 6088
    Helixi615 – 62612
    Beta strandi627 – 6293
    Beta strandi638 – 6425
    Beta strandi645 – 6473
    Turni650 – 6545
    Helixi656 – 6627
    Beta strandi663 – 6653
    Beta strandi671 – 6777
    Helixi682 – 6865

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4KBTX-ray3.86Y4-690[»]
    4KBVX-ray3.86Y4-690[»]
    4KCYX-ray3.50Y4-690[»]
    4KD0X-ray3.50Y4-690[»]
    4KD8X-ray3.50Y4-690[»]
    4KDAX-ray3.50Y4-690[»]
    4KDGX-ray4.00Y4-690[»]
    4KDJX-ray4.00Y4-690[»]
    ProteinModelPortaliQ72I01.
    SMRiQ72I01. Positions 4-689.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 284275tr-type GAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0480.
    KOiK02355.
    OMAiFETSMAN.
    OrthoDBiEOG6X6RBF.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00054_B. EF_G_EF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR004540. Transl_elong_EFG/EF2.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PfamiPF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SMARTiSM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsiTIGR00484. EF-G. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q72I01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVKVEYDLK RLRNIGIAAH IDAGKTTTTE RILYYTGRIH KIGEVHEGAA    50
    TMDFMEQERE RGITITAAVT TCFWKDHRIN IIDTPGHVDF TIEVERSMRV 100
    LDGAIVVFDS SQGVEPQSET VWRQAEKYHV PRIAFANKMD KTGADLWLVI 150
    RTMQERLGAR PVVMQLPIGR EDTFSGIIDV LRMKAYTYGN DLGTDIREIP 200
    IPEEYLDQAR EYHEKLVEVA ADFDEHIMLK YLEGEEPTEE ELVAAIRKGT 250
    IDLKITPVFL GSALKNKGVQ LLLDAVVDYL PSPLDIPPIK GTTPEGEVVE 300
    IHPDPNGPLA ALAFKIMADP YVGRLTFIRV YSGTLTSGSY VYNTTKGRKE 350
    RVARLLRMHA NHREEVEELK AGDLGAVVGL KETITGDTLV GEDAPRVILE 400
    SIEVPEPVID VAIEPKTKAD QEKLSQALAR LAEEDPTFRV STHPETGQTI 450
    ISGMGELHLE IIVDRLKREF KVDANVGKPQ VAYRETITKP VDVEGKFIRQ 500
    TGGRGQYGHV KIKVEPLPRG SGFEFVNAIV GGVIPKEYIP AVQKGIEEAM 550
    QSGPLIGFPV VDIKVTLYDG SYHEVDSSEM AFKIAGSMAI KEAVQKGDPV 600
    ILEPIMRVEV TTPEEYMGDV IGDLNARRGQ ILGMEPRGNA QVIRAFVPLA 650
    EMFGYATDLR SKTQGRGSFV MFFDHYQEVP KQVQEKLIKG Q 691
    Length:691
    Mass (Da):76,911
    Last modified:July 5, 2004 - v1
    Checksum:i109D07619C9EEC81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81673.1.
    RefSeqiWP_011173716.1. NC_005835.1.
    YP_005300.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS81673; AAS81673; TT_C1331.
    GeneIDi2775872.
    KEGGitth:TTC1331.
    PATRICi23953069. VBITheThe54392_1323.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81673.1 .
    RefSeqi WP_011173716.1. NC_005835.1.
    YP_005300.1. NC_005835.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4KBT X-ray 3.86 Y 4-690 [» ]
    4KBV X-ray 3.86 Y 4-690 [» ]
    4KCY X-ray 3.50 Y 4-690 [» ]
    4KD0 X-ray 3.50 Y 4-690 [» ]
    4KD8 X-ray 3.50 Y 4-690 [» ]
    4KDA X-ray 3.50 Y 4-690 [» ]
    4KDG X-ray 4.00 Y 4-690 [» ]
    4KDJ X-ray 4.00 Y 4-690 [» ]
    ProteinModelPortali Q72I01.
    SMRi Q72I01. Positions 4-689.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS81673 ; AAS81673 ; TT_C1331 .
    GeneIDi 2775872.
    KEGGi tth:TTC1331.
    PATRICi 23953069. VBITheThe54392_1323.

    Phylogenomic databases

    eggNOGi COG0480.
    KOi K02355.
    OMAi FETSMAN.
    OrthoDBi EOG6X6RBF.

    Enzyme and pathway databases

    BioCyci TTHE262724:GCAT-1346-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00054_B. EF_G_EF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR004540. Transl_elong_EFG/EF2.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    Pfami PF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SMARTi SM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsi TIGR00484. EF-G. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.

    Entry informationi

    Entry nameiEFG_THET2
    AccessioniPrimary (citable) accession number: Q72I01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3