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Q72I01

- EFG_THET2

UniProt

Q72I01 - EFG_THET2

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Protein

Elongation factor G

Gene

fusA

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi83 – 875GTPUniRule annotation
Nucleotide bindingi137 – 1404GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor GUniRule annotation
Short name:
EF-GUniRule annotation
Gene namesi
Name:fusAUniRule annotation
Ordered Locus Names:TT_C1331
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Elongation factor GPRO_0000091247Add
BLAST

Structurei

Secondary structure

1
691
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 157Combined sources
Beta strandi20 – 223Combined sources
Helixi25 – 339Combined sources
Turni56 – 616Combined sources
Beta strandi66 – 683Combined sources
Beta strandi73 – 764Combined sources
Beta strandi77 – 826Combined sources
Helixi93 – 986Combined sources
Beta strandi104 – 1074Combined sources
Turni111 – 1144Combined sources
Helixi116 – 1183Combined sources
Helixi121 – 1255Combined sources
Beta strandi132 – 1354Combined sources
Beta strandi139 – 1435Combined sources
Helixi147 – 1537Combined sources
Turni154 – 1574Combined sources
Beta strandi165 – 1684Combined sources
Turni171 – 1733Combined sources
Beta strandi177 – 1826Combined sources
Beta strandi184 – 1874Combined sources
Beta strandi190 – 1923Combined sources
Beta strandi203 – 2053Combined sources
Helixi206 – 21914Combined sources
Turni220 – 2234Combined sources
Helixi227 – 2326Combined sources
Helixi239 – 25113Combined sources
Turni263 – 2664Combined sources
Helixi269 – 27911Combined sources
Turni283 – 2853Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2963Combined sources
Beta strandi298 – 3003Combined sources
Beta strandi310 – 3178Combined sources
Turni320 – 3223Combined sources
Beta strandi324 – 3296Combined sources
Beta strandi340 – 3467Combined sources
Beta strandi351 – 3599Combined sources
Beta strandi362 – 3698Combined sources
Beta strandi375 – 3795Combined sources
Beta strandi388 – 3947Combined sources
Beta strandi409 – 4135Combined sources
Turni416 – 4205Combined sources
Helixi421 – 43414Combined sources
Beta strandi439 – 4424Combined sources
Beta strandi444 – 45613Combined sources
Helixi457 – 46913Combined sources
Beta strandi484 – 4863Combined sources
Beta strandi491 – 4955Combined sources
Beta strandi509 – 5146Combined sources
Beta strandi530 – 5345Combined sources
Turni540 – 5445Combined sources
Helixi545 – 5506Combined sources
Turni554 – 5563Combined sources
Beta strandi569 – 5713Combined sources
Beta strandi574 – 5763Combined sources
Helixi579 – 59517Combined sources
Beta strandi601 – 6088Combined sources
Helixi615 – 62612Combined sources
Beta strandi627 – 6293Combined sources
Beta strandi638 – 6425Combined sources
Beta strandi645 – 6473Combined sources
Turni650 – 6545Combined sources
Helixi656 – 6627Combined sources
Beta strandi663 – 6653Combined sources
Beta strandi671 – 6777Combined sources
Helixi682 – 6865Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KBTX-ray3.86Y4-690[»]
4KBVX-ray3.86Y4-690[»]
4KCYX-ray3.50Y4-690[»]
4KD0X-ray3.50Y4-690[»]
4KD8X-ray3.50Y4-690[»]
4KDAX-ray3.50Y4-690[»]
4KDGX-ray4.00Y4-690[»]
4KDJX-ray4.00Y4-690[»]
4QS0X-ray3.80Y4-690[»]
4QS2X-ray3.80Y4-690[»]
ProteinModelPortaliQ72I01.
SMRiQ72I01. Positions 4-689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 284275tr-type GAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0480.
KOiK02355.
OMAiFETSMAN.
OrthoDBiEOG6X6RBF.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72I01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVKVEYDLK RLRNIGIAAH IDAGKTTTTE RILYYTGRIH KIGEVHEGAA
60 70 80 90 100
TMDFMEQERE RGITITAAVT TCFWKDHRIN IIDTPGHVDF TIEVERSMRV
110 120 130 140 150
LDGAIVVFDS SQGVEPQSET VWRQAEKYHV PRIAFANKMD KTGADLWLVI
160 170 180 190 200
RTMQERLGAR PVVMQLPIGR EDTFSGIIDV LRMKAYTYGN DLGTDIREIP
210 220 230 240 250
IPEEYLDQAR EYHEKLVEVA ADFDEHIMLK YLEGEEPTEE ELVAAIRKGT
260 270 280 290 300
IDLKITPVFL GSALKNKGVQ LLLDAVVDYL PSPLDIPPIK GTTPEGEVVE
310 320 330 340 350
IHPDPNGPLA ALAFKIMADP YVGRLTFIRV YSGTLTSGSY VYNTTKGRKE
360 370 380 390 400
RVARLLRMHA NHREEVEELK AGDLGAVVGL KETITGDTLV GEDAPRVILE
410 420 430 440 450
SIEVPEPVID VAIEPKTKAD QEKLSQALAR LAEEDPTFRV STHPETGQTI
460 470 480 490 500
ISGMGELHLE IIVDRLKREF KVDANVGKPQ VAYRETITKP VDVEGKFIRQ
510 520 530 540 550
TGGRGQYGHV KIKVEPLPRG SGFEFVNAIV GGVIPKEYIP AVQKGIEEAM
560 570 580 590 600
QSGPLIGFPV VDIKVTLYDG SYHEVDSSEM AFKIAGSMAI KEAVQKGDPV
610 620 630 640 650
ILEPIMRVEV TTPEEYMGDV IGDLNARRGQ ILGMEPRGNA QVIRAFVPLA
660 670 680 690
EMFGYATDLR SKTQGRGSFV MFFDHYQEVP KQVQEKLIKG Q
Length:691
Mass (Da):76,911
Last modified:July 5, 2004 - v1
Checksum:i109D07619C9EEC81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81673.1.
RefSeqiYP_005300.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81673; AAS81673; TT_C1331.
GeneIDi2775872.
KEGGitth:TTC1331.
PATRICi23953069. VBITheThe54392_1323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81673.1 .
RefSeqi YP_005300.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KBT X-ray 3.86 Y 4-690 [» ]
4KBV X-ray 3.86 Y 4-690 [» ]
4KCY X-ray 3.50 Y 4-690 [» ]
4KD0 X-ray 3.50 Y 4-690 [» ]
4KD8 X-ray 3.50 Y 4-690 [» ]
4KDA X-ray 3.50 Y 4-690 [» ]
4KDG X-ray 4.00 Y 4-690 [» ]
4KDJ X-ray 4.00 Y 4-690 [» ]
4QS0 X-ray 3.80 Y 4-690 [» ]
4QS2 X-ray 3.80 Y 4-690 [» ]
ProteinModelPortali Q72I01.
SMRi Q72I01. Positions 4-689.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS81673 ; AAS81673 ; TT_C1331 .
GeneIDi 2775872.
KEGGi tth:TTC1331.
PATRICi 23953069. VBITheThe54392_1323.

Phylogenomic databases

eggNOGi COG0480.
KOi K02355.
OMAi FETSMAN.
OrthoDBi EOG6X6RBF.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1346-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00054_B. EF_G_EF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
Pfami PF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SMARTi SM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsi TIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiEFG_THET2
AccessioniPrimary (citable) accession number: Q72I01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3