Q72HH0 (Q72HH0_THET2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I HAMAP MF_00223

Gene names

Name:	folE HAMAP MF_00223
Ordered Locus Names:	TT_C1517

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223 SAAS SAAS001474
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223 SAAS SAAS001474
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 SAAS SAAS001474 Nucleotide-binding Zinc HAMAP MF_00223 SAAS SAAS001474
Molecular function	Hydrolase HAMAP MF_00223 SAAS SAAS001474 EMBL AAS81859.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	94	1	Zinc By similarity HAMAP MF_00223
	Metal binding	97	1	Zinc By similarity HAMAP MF_00223
	Metal binding	165	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	Q72HH0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 86E2DA067D028086	FASTA	207	23,306
	10 20 30 40 50 60 MERKMVELED TGLTFATEVD LERLQALAAE WLQVIGEDPG REGLLKTPER VAKAWAFLTR 70 80 90 100 110 120 GYRQRLEEVV GGAVFPAEGS EMVVVKGVEF YSMCEHHLLP FFGKVHIGYI PDGKILGLSK 130 140 150 160 170 180 FARIVDMFAR RLQVQERLAV QIAEAIQEVL EPQGVGVVVE GVHLCMMMRG VEKQHSRTVT 190 200 SAMLGVFREN QKTREEFLSH LKDPLGL

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS81859.1.
RefSeq	YP_005486.1. NC_005835.1.
3D structure databases
HSSP	HSSP built from PDB template 1A8R based on UniProtKB P27511.
ProteinModelPortal	Q72HH0.
SMR	Q72HH0. Positions 18-202.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72HH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2776286.
GenomeReviews	Gene locus TT_C1517 in contig AE017221_GR.
PATRIC	23953455. VBITheThe54392_1510.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HBG370191.
OMA	KQIATAM.
PhylomeDB	Q72HH0.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C1517-MONOMER.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q72HH0_THET2

Accession

Primary (citable) accession number: Q72HH0

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)