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Q72HF4

- GLMS_THET2

UniProt

Q72HF4 - GLMS_THET2

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, TT_C1533
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei599 – 5991For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1554-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:TT_C1533
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135401Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1533.

Structurei

3D structure databases

ProteinModelPortaliQ72HF4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 216215Glutamine amidotransferase type-2Add
BLAST
Domaini281 – 420140SIS 1Add
BLAST
Domaini453 – 594142SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiKEWLEDE.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q72HF4-1 [UniParc]FASTAAdd to Basket

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MCGIVGYVGF RNATDVLLDG LRRLEYRGYD SAGIAVRTPE GLKVVKRSGK    50
LSALAQAVGK TPLQGALGIG HTRWATHGAP TDPNAHPHTT EDGRIALIHN 100
GIFENYLELK EALEARGHRF RSETDTEVLA HLLEETYRGD LLEALREALK 150
AVRGAYAVVV AHEDHEEIVA ARTVSPLVVG LGEGENFLAS DVPALLPYTR 200
RVIFLHDGDV VRLTREGVEI TDLEGRPVQR EAVEVDWTLE AAEKGGFPHY 250
MLKEIYEQPW VLENTLGGRL REEEGTVELG LALDPREVDR VHVIACGTAS 300
YAGLYGKYLL ETLARLPTEW DVASEYRYRD PVVDSRTLAL AISQSGETID 350
TLEGLREAKR KGARSLGVIN AKGSTLTREV EDVLYIHAGP EIGVASTKAY 400
TAMLVAMALL AVWFGRARGA LALEEAQSLL REMRRLPRLV EEVLEKRPLV 450
AHVAEKYHQA RDFLFLGRHV QAPTAYEGAL KLKEISYIHA EAYPAGEMKH 500
GPIALIDEHL PVVVLATKGP LYEKTLSNIQ EVRARGGKVI AIATEGDEEI 550
PRLAQDVIYV PEVHPLLAPI VSVVPLQLLA YEIAVLLGRD VDQPRNLAKS 600
VTVE 604
Length:604
Mass (Da):66,457
Last modified:January 23, 2007 - v3
Checksum:iCCC0DA220A9E69F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81875.1.
RefSeqiWP_011173907.1. NC_005835.1.
YP_005502.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81875; AAS81875; TT_C1533.
GeneIDi2774876.
KEGGitth:TTC1533.
PATRICi23953491. VBITheThe54392_1528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81875.1 .
RefSeqi WP_011173907.1. NC_005835.1.
YP_005502.1. NC_005835.1.

3D structure databases

ProteinModelPortali Q72HF4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS81875 ; AAS81875 ; TT_C1533 .
GeneIDi 2774876.
KEGGi tth:TTC1533.
PATRICi 23953491. VBITheThe54392_1528.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi KEWLEDE.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1554-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiGLMS_THET2
AccessioniPrimary (citable) accession number: Q72HF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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