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Q72HF4

- GLMS_THET2

UniProt

Q72HF4 - GLMS_THET2

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei599 – 5991For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1554-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:TT_C1533
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135401Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262724.TTC1533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ72HF4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 216215Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini281 – 420140SIS 1UniRule annotationAdd
    BLAST
    Domaini453 – 594142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiKEWLEDE.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q72HF4-1 [UniParc]FASTAAdd to Basket

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    MCGIVGYVGF RNATDVLLDG LRRLEYRGYD SAGIAVRTPE GLKVVKRSGK    50
    LSALAQAVGK TPLQGALGIG HTRWATHGAP TDPNAHPHTT EDGRIALIHN 100
    GIFENYLELK EALEARGHRF RSETDTEVLA HLLEETYRGD LLEALREALK 150
    AVRGAYAVVV AHEDHEEIVA ARTVSPLVVG LGEGENFLAS DVPALLPYTR 200
    RVIFLHDGDV VRLTREGVEI TDLEGRPVQR EAVEVDWTLE AAEKGGFPHY 250
    MLKEIYEQPW VLENTLGGRL REEEGTVELG LALDPREVDR VHVIACGTAS 300
    YAGLYGKYLL ETLARLPTEW DVASEYRYRD PVVDSRTLAL AISQSGETID 350
    TLEGLREAKR KGARSLGVIN AKGSTLTREV EDVLYIHAGP EIGVASTKAY 400
    TAMLVAMALL AVWFGRARGA LALEEAQSLL REMRRLPRLV EEVLEKRPLV 450
    AHVAEKYHQA RDFLFLGRHV QAPTAYEGAL KLKEISYIHA EAYPAGEMKH 500
    GPIALIDEHL PVVVLATKGP LYEKTLSNIQ EVRARGGKVI AIATEGDEEI 550
    PRLAQDVIYV PEVHPLLAPI VSVVPLQLLA YEIAVLLGRD VDQPRNLAKS 600
    VTVE 604
    Length:604
    Mass (Da):66,457
    Last modified:January 23, 2007 - v3
    Checksum:iCCC0DA220A9E69F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81875.1.
    RefSeqiWP_011173907.1. NC_005835.1.
    YP_005502.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS81875; AAS81875; TT_C1533.
    GeneIDi2774876.
    KEGGitth:TTC1533.
    PATRICi23953491. VBITheThe54392_1528.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81875.1 .
    RefSeqi WP_011173907.1. NC_005835.1.
    YP_005502.1. NC_005835.1.

    3D structure databases

    ProteinModelPortali Q72HF4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TTC1533.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS81875 ; AAS81875 ; TT_C1533 .
    GeneIDi 2774876.
    KEGGi tth:TTC1533.
    PATRICi 23953491. VBITheThe54392_1528.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi KEWLEDE.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci TTHE262724:GCAT-1554-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.

    Entry informationi

    Entry nameiGLMS_THET2
    AccessioniPrimary (citable) accession number: Q72HF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3