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Q72HF4 (GLMS_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
EC=2.6.1.16
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene names
Name:glmS
Ordered Locus Names:TT_C1533
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›

Protein attributes

Sequence length604 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity. HAMAP-Rule MF_00164

Catalytic activity

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. HAMAP-Rule MF_00164

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 glutamine amidotransferase type-2 domain.

Contains 2 SIS domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing] HAMAP-Rule MF_00164
PRO_0000135401

Regions

Domain2 – 216215Glutamine amidotransferase type-2
Domain281 – 420140SIS 1
Domain453 – 594142SIS 2

Sites

Active site21Nucleophile; for GATase activity By similarity
Active site5991For Fru-6P isomerization activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72HF4 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: CCC0DA220A9E69F1

FASTA60466,457
        10         20         30         40         50         60 
MCGIVGYVGF RNATDVLLDG LRRLEYRGYD SAGIAVRTPE GLKVVKRSGK LSALAQAVGK 

        70         80         90        100        110        120 
TPLQGALGIG HTRWATHGAP TDPNAHPHTT EDGRIALIHN GIFENYLELK EALEARGHRF 

       130        140        150        160        170        180 
RSETDTEVLA HLLEETYRGD LLEALREALK AVRGAYAVVV AHEDHEEIVA ARTVSPLVVG 

       190        200        210        220        230        240 
LGEGENFLAS DVPALLPYTR RVIFLHDGDV VRLTREGVEI TDLEGRPVQR EAVEVDWTLE 

       250        260        270        280        290        300 
AAEKGGFPHY MLKEIYEQPW VLENTLGGRL REEEGTVELG LALDPREVDR VHVIACGTAS 

       310        320        330        340        350        360 
YAGLYGKYLL ETLARLPTEW DVASEYRYRD PVVDSRTLAL AISQSGETID TLEGLREAKR 

       370        380        390        400        410        420 
KGARSLGVIN AKGSTLTREV EDVLYIHAGP EIGVASTKAY TAMLVAMALL AVWFGRARGA 

       430        440        450        460        470        480 
LALEEAQSLL REMRRLPRLV EEVLEKRPLV AHVAEKYHQA RDFLFLGRHV QAPTAYEGAL 

       490        500        510        520        530        540 
KLKEISYIHA EAYPAGEMKH GPIALIDEHL PVVVLATKGP LYEKTLSNIQ EVRARGGKVI 

       550        560        570        580        590        600 
AIATEGDEEI PRLAQDVIYV PEVHPLLAPI VSVVPLQLLA YEIAVLLGRD VDQPRNLAKS 


VTVE

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017221 Genomic DNA. Translation: AAS81875.1.
RefSeqYP_005502.1. NC_005835.1.

3D structure databases

ProteinModelPortalQ72HF4.
ModBaseSearch...

Protein-protein interaction databases

STRING262724.TTC1533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS81875; AAS81875; TT_C1533.
GeneID2774876.
KEGGtth:TTC1533.
PATRIC23953491. VBITheThe54392_1528.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0449.
KOK00820.
OMACLQGLER.
ProtClustDBPRK00331.

Family and domain databases

HAMAPMF_00164. GlmS.
InterProIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR001347. SIS.
[Graphical view]
PANTHERPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
TIGRFAMsTIGR01135. glmS. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLMS_THET2
AccessionPrimary (citable) accession number: Q72HF4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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