Q72HA9 (Q72HA9_THET2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetylglutamate/acetylaminoadipate kinase HAMAP MF_00082
EC=2.7.2.- HAMAP MF_00082
EC=2.7.2.8 HAMAP MF_00082

Alternative name(s):
N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase HAMAP MF_00082
NAG kinase HAMAP MF_00082

Gene names

Name:	argB HAMAP MF_00082
Synonyms:	lysZ HAMAP MF_00082
Ordered Locus Names:	TT_C1586

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP MF_00082
Catalytic activity	ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate. HAMAP MF_00082 ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082 Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5. HAMAP MF_00082
Subcellular location	Cytoplasm By similarity HAMAP MF_00082.
Sequence similarities	Belongs to the acetylglutamate kinase family. HAMAP MF_00082

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis HAMAP MF_00082 Lysine biosynthesis HAMAP MF_00082
Cellular component	Cytoplasm HAMAP MF_00082
Ligand	ATP-binding HAMAP MF_00082 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00082 EMBL AAS81928.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP lysine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	36 – 37	2	Substrate binding By similarity HAMAP MF_00082
Sites
	Binding site	58	1	Substrate By similarity HAMAP MF_00082
	Binding site	147	1	Substrate By similarity HAMAP MF_00082
	Site	8	1	Transition state stabilizer By similarity HAMAP MF_00082
	Site	209	1	Transition state stabilizer By similarity HAMAP MF_00082

Sequences

	Sequence		Length	Mass (Da)
	Q72HA9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 74DB2B94AAF92170	FASTA	248	25,897
	10 20 30 40 50 60 MSEALLVKVG GSLRGAEALL DELAAYPGPL VLVHGGGPEI GAWLGRLGYE SRFVGGLRVT 70 80 90 100 110 120 PPEQLEVVEM ALYLTGKRLA EGLSRRGRKA LALSGRDALC LKGRALPELG RVGEVVEVEV 130 140 150 160 170 180 GLLQDLLAKG YTPLLAPIAL DAEGPLNVNA DTAAGAVAGA LGWPAVFLTD VEGVYRDPKD 190 200 210 220 230 240 PRTRFPRLTP KEVEALKGEG VIQGGMIPKV EAALSALRAG APWAAIAKGE RGVLEAVLRG EAGTRFTL

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS81928.1.
RefSeq	YP_005555.1. NC_005835.1.
3D structure databases
ProteinModelPortal	Q72HA9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72HA9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2774868.
GenomeReviews	Gene locus TT_C1586 in contig AE017221_GR.
PATRIC	23953609. VBITheThe54392_1582.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	CNINVEK.
PhylomeDB	Q72HA9.
ProtClustDB	CLSK445594.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C1586-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q72HA9_THET2

Accession

Primary (citable) accession number: Q72HA9

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)