Q72H95 (Q72H95_THET2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Inorganic pyrophosphatase HAMAP MF_00209
EC=3.6.1.1 HAMAP MF_00209

Alternative name(s):
Pyrophosphate phospho-hydrolase HAMAP MF_00209

Gene names

Name:	ppa HAMAP MF_00209
Ordered Locus Names:	TT_C1600

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_00209
Cofactor	Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity. HAMAP MF_00209
Subcellular location	Cytoplasm By similarity HAMAP MF_00209.
Sequence similarities	Belongs to the PPase family. HAMAP MF_00209

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00209
Ligand	Magnesium HAMAP MF_00209 Metal-binding HAMAP MF_00209
Molecular function	Hydrolase HAMAP MF_00209 EMBL AAS81942.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphate-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inorganic diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	66	1	Magnesium 1 By similarity HAMAP MF_00209
	Metal binding	71	1	Magnesium 1 By similarity HAMAP MF_00209
	Metal binding	71	1	Magnesium 2 By similarity HAMAP MF_00209
	Metal binding	103	1	Magnesium 1 By similarity HAMAP MF_00209

Sequences

	Sequence		Length	Mass (Da)
	Q72H95 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 01306D30B31DB061	FASTA	175	19,216
	10 20 30 40 50 60 MANLKSLPVG DKAPEVVHMV IEVPRGSGNK YEYDPDLGAI KLDRVLPGAQ FYPGDYGFIP 70 80 90 100 110 120 STLAEDGDPL DGLVLSTYPL LPGVVVEVRV VGLLLMEDEK GGDAKVIGVV AEDQRLDHIQ 130 140 150 160 170 DIGDVPEGVK QEIQHFFETY KALEAKKGKW VKVTGWRDRK AALEEVRACI ARYKG

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS81942.1.
RefSeq	YP_005569.1. NC_005835.1.
3D structure databases
ProteinModelPortal	Q72H95.
SMR	Q72H95. Positions 2-175.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72H95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2775556.
GenomeReviews	Gene locus TT_C1600 in contig AE017221_GR.
PATRIC	23953637. VBITheThe54392_1596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0221.
HOGENOM	HBG529150.
OMA	AMVIMEE.
PhylomeDB	Q72H95.
ProtClustDB	CLSK738884.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C1600-MONOMER.
Family and domain databases
HAMAP	MF_00209. Inorganic_PPase. [Tree]
InterPro	IPR008162. Pyrophosphatase. [Graphical view]
Gene3D	G3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
PANTHER	PTHR10286. Pyrophosphatase. 1 hit.
Pfam	PF00719. Pyrophosphatase. 1 hit. [Graphical view]
SUPFAM	SSF50324. Pyrophosphatase. 1 hit.
PROSITE	PS00387. PPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q72H95_THET2

Accession

Primary (citable) accession number: Q72H95

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)