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Q72H32 (FMT_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methionyl-tRNA formyltransferase

EC=2.1.2.9
Gene names
Name:fmt
Ordered Locus Names:TT_C1663
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182

Catalytic activity

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182

Sequence similarities

Belongs to the Fmt family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranslational initiation

Inferred from electronic annotation. Source: GOC

   Molecular_functionmethionyl-tRNA formyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
PRO_0000083072

Regions

Region108 – 1114Tetrahydrofolate (THF) binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72H32 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1AA26B3FFBC82B46

FASTA30533,323
        10         20         30         40         50         60 
MRVAFFGTPL WAVPVLDALR KRHQVVLVVS QPDKPQGRGL RPAPSPVARY AEAEGLPLLR 

        70         80         90        100        110        120 
PARLREEAFL EALRQAAPEV AVVAAYGKLI PKEALDIPPH GFLNLHPSLL PKYRGAAPVQ 

       130        140        150        160        170        180 
RALLAGERET GVSIMRLDEG LDTGPLYAVW RTPILPDEDA VALGNRLRDK GVELLLEVLE 

       190        200        210        220        230        240 
RLPELTPRPQ EGEVSYAPPL SKEEGRLDFG ESAEALYRRH RAVQPWPGSY FFHRGRRVKA 

       250        260        270        280        290        300 
LRLRPEPGEG EPGVVARVGP EGVAVGTASG LLLLLEVQPE GRRAMPAADW ARGYGVAPGT 


RLGQV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017221 Genomic DNA. Translation: AAS82005.1.
RefSeqYP_005632.1. NC_005835.1.

3D structure databases

ProteinModelPortalQ72H32.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS82005; AAS82005; TT_C1663.
GeneID2776013.
KEGGtth:TTC1663.
PATRIC23953773. VBITheThe54392_1660.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0223.
KOK00604.
OMAKVWKAEV.
OrthoDBEOG6B09WV.
ProtClustDBCLSK738496.

Enzyme and pathway databases

BioCycTTHE262724:GCAT-1693-MONOMER.

Family and domain databases

Gene3D3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPMF_00182. Formyl_trans.
InterProIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERPTHR11138. PTHR11138. 1 hit.
PfamPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsTIGR00460. fmt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFMT_THET2
AccessionPrimary (citable) accession number: Q72H32
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families