SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q72GY9

- FTHS_THET2

UniProt

Q72GY9 - FTHS_THET2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene
fhs, TT_C1707
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 618ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1740-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:TT_C1707
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199404Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1707.

Structurei

3D structure databases

ProteinModelPortaliQ72GY9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiDPKKINA.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72GY9-1 [UniParc]FASTAAdd to Basket

« Hide

MIVKEDLLPI EEVAAKLGLD RDRLYLYGPH MAKVLGEPPK AKGKLVLVTA    50
ITPTPAGEGK TTTAIGLVDA LWRLGKRAAL ALREPSLGPV FGVKGGATGG 100
GKARVEPRHE INLHFTGDFH AVTSAVNLLN ALLDNHLHQG NELGIDPRRI 150
ELKRAIDMND RALRHIVLGL GGKAHGVPRE GGFELTVASE VMALMSLARD 200
FQDLKRRLGR MRVAFTHEGK PVYAEDLMAV GAMAALLRQA FLPNLVQTAE 250
GNPAFIHMGP FGNIAHGTNS LRASLFALGL ADLVVQEAGF ATDLGLEKFM 300
NVVARTTGLV PEAVVLVATI RALRYHGGQD AYGMPDPKAV KAGLANLEKH 350
VENVELFGYK PVIALNRFPS DAPEEIALVR AFAEERGLPF APSEVYAQGG 400
EGGLELAERV LEALDLPHAY RPLYPLEASL EAKVEAIATR VYGAEGVEWS 450
EEAKRALKAA KKEGCEALPV VVAKAATSLS DNPRLRGRPR GFTVRVTDLR 500
CRLGAGFVVV YMGGIETLPG LPKTPQAFGI DVDEEGNIRG MDY 543
Length:543
Mass (Da):58,348
Last modified:July 5, 2004 - v1
Checksum:i09FCE0CBF76D665E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82049.1.
RefSeqiWP_011174070.1. NC_005835.1.
YP_005676.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82049; AAS82049; TT_C1707.
GeneIDi2774883.
KEGGitth:TTC1707.
PATRICi23953871. VBITheThe54392_1706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82049.1 .
RefSeqi WP_011174070.1. NC_005835.1.
YP_005676.1. NC_005835.1.

3D structure databases

ProteinModelPortali Q72GY9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82049 ; AAS82049 ; TT_C1707 .
GeneIDi 2774883.
KEGGi tth:TTC1707.
PATRICi 23953871. VBITheThe54392_1706.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi DPKKINA.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TTHE262724:GCAT-1740-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiFTHS_THET2
AccessioniPrimary (citable) accession number: Q72GY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi