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Q72GY9 (FTHS_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:TT_C1707
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199404

Regions

Nucleotide binding54 – 618ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72GY9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 09FCE0CBF76D665E

FASTA54358,348
        10         20         30         40         50         60 
MIVKEDLLPI EEVAAKLGLD RDRLYLYGPH MAKVLGEPPK AKGKLVLVTA ITPTPAGEGK 

        70         80         90        100        110        120 
TTTAIGLVDA LWRLGKRAAL ALREPSLGPV FGVKGGATGG GKARVEPRHE INLHFTGDFH 

       130        140        150        160        170        180 
AVTSAVNLLN ALLDNHLHQG NELGIDPRRI ELKRAIDMND RALRHIVLGL GGKAHGVPRE 

       190        200        210        220        230        240 
GGFELTVASE VMALMSLARD FQDLKRRLGR MRVAFTHEGK PVYAEDLMAV GAMAALLRQA 

       250        260        270        280        290        300 
FLPNLVQTAE GNPAFIHMGP FGNIAHGTNS LRASLFALGL ADLVVQEAGF ATDLGLEKFM 

       310        320        330        340        350        360 
NVVARTTGLV PEAVVLVATI RALRYHGGQD AYGMPDPKAV KAGLANLEKH VENVELFGYK 

       370        380        390        400        410        420 
PVIALNRFPS DAPEEIALVR AFAEERGLPF APSEVYAQGG EGGLELAERV LEALDLPHAY 

       430        440        450        460        470        480 
RPLYPLEASL EAKVEAIATR VYGAEGVEWS EEAKRALKAA KKEGCEALPV VVAKAATSLS 

       490        500        510        520        530        540 
DNPRLRGRPR GFTVRVTDLR CRLGAGFVVV YMGGIETLPG LPKTPQAFGI DVDEEGNIRG 


MDY 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017221 Genomic DNA. Translation: AAS82049.1.
RefSeqYP_005676.1. NC_005835.1.

3D structure databases

ProteinModelPortalQ72GY9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262724.TTC1707.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS82049; AAS82049; TT_C1707.
GeneID2774883.
KEGGtth:TTC1707.
PATRIC23953871. VBITheThe54392_1706.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMADPKKINA.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycTTHE262724:GCAT-1740-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THET2
AccessionPrimary (citable) accession number: Q72GY9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways