Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 618ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1740-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:TT_C1707
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Formate--tetrahydrofolate ligasePRO_0000199404Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1707.

Structurei

3D structure databases

ProteinModelPortaliQ72GY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72GY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVKEDLLPI EEVAAKLGLD RDRLYLYGPH MAKVLGEPPK AKGKLVLVTA
60 70 80 90 100
ITPTPAGEGK TTTAIGLVDA LWRLGKRAAL ALREPSLGPV FGVKGGATGG
110 120 130 140 150
GKARVEPRHE INLHFTGDFH AVTSAVNLLN ALLDNHLHQG NELGIDPRRI
160 170 180 190 200
ELKRAIDMND RALRHIVLGL GGKAHGVPRE GGFELTVASE VMALMSLARD
210 220 230 240 250
FQDLKRRLGR MRVAFTHEGK PVYAEDLMAV GAMAALLRQA FLPNLVQTAE
260 270 280 290 300
GNPAFIHMGP FGNIAHGTNS LRASLFALGL ADLVVQEAGF ATDLGLEKFM
310 320 330 340 350
NVVARTTGLV PEAVVLVATI RALRYHGGQD AYGMPDPKAV KAGLANLEKH
360 370 380 390 400
VENVELFGYK PVIALNRFPS DAPEEIALVR AFAEERGLPF APSEVYAQGG
410 420 430 440 450
EGGLELAERV LEALDLPHAY RPLYPLEASL EAKVEAIATR VYGAEGVEWS
460 470 480 490 500
EEAKRALKAA KKEGCEALPV VVAKAATSLS DNPRLRGRPR GFTVRVTDLR
510 520 530 540
CRLGAGFVVV YMGGIETLPG LPKTPQAFGI DVDEEGNIRG MDY
Length:543
Mass (Da):58,348
Last modified:July 5, 2004 - v1
Checksum:i09FCE0CBF76D665E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82049.1.
RefSeqiWP_011174070.1. NC_005835.1.
YP_005676.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82049; AAS82049; TT_C1707.
GeneIDi2774883.
KEGGitth:TTC1707.
PATRICi23953871. VBITheThe54392_1706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82049.1.
RefSeqiWP_011174070.1. NC_005835.1.
YP_005676.1. NC_005835.1.

3D structure databases

ProteinModelPortaliQ72GY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC1707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS82049; AAS82049; TT_C1707.
GeneIDi2774883.
KEGGitth:TTC1707.
PATRICi23953871. VBITheThe54392_1706.

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciTTHE262724:GCAT-1740-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiFTHS_THET2
AccessioniPrimary (citable) accession number: Q72GY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.