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Q72GY9

- FTHS_THET2

UniProt

Q72GY9 - FTHS_THET2

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 618ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1740-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:TT_C1707
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Formate--tetrahydrofolate ligasePRO_0000199404Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1707.

Structurei

3D structure databases

ProteinModelPortaliQ72GY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiDPKKINA.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72GY9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVKEDLLPI EEVAAKLGLD RDRLYLYGPH MAKVLGEPPK AKGKLVLVTA
60 70 80 90 100
ITPTPAGEGK TTTAIGLVDA LWRLGKRAAL ALREPSLGPV FGVKGGATGG
110 120 130 140 150
GKARVEPRHE INLHFTGDFH AVTSAVNLLN ALLDNHLHQG NELGIDPRRI
160 170 180 190 200
ELKRAIDMND RALRHIVLGL GGKAHGVPRE GGFELTVASE VMALMSLARD
210 220 230 240 250
FQDLKRRLGR MRVAFTHEGK PVYAEDLMAV GAMAALLRQA FLPNLVQTAE
260 270 280 290 300
GNPAFIHMGP FGNIAHGTNS LRASLFALGL ADLVVQEAGF ATDLGLEKFM
310 320 330 340 350
NVVARTTGLV PEAVVLVATI RALRYHGGQD AYGMPDPKAV KAGLANLEKH
360 370 380 390 400
VENVELFGYK PVIALNRFPS DAPEEIALVR AFAEERGLPF APSEVYAQGG
410 420 430 440 450
EGGLELAERV LEALDLPHAY RPLYPLEASL EAKVEAIATR VYGAEGVEWS
460 470 480 490 500
EEAKRALKAA KKEGCEALPV VVAKAATSLS DNPRLRGRPR GFTVRVTDLR
510 520 530 540
CRLGAGFVVV YMGGIETLPG LPKTPQAFGI DVDEEGNIRG MDY
Length:543
Mass (Da):58,348
Last modified:July 5, 2004 - v1
Checksum:i09FCE0CBF76D665E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82049.1.
RefSeqiYP_005676.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82049; AAS82049; TT_C1707.
GeneIDi2774883.
KEGGitth:TTC1707.
PATRICi23953871. VBITheThe54392_1706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82049.1 .
RefSeqi YP_005676.1. NC_005835.1.

3D structure databases

ProteinModelPortali Q72GY9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82049 ; AAS82049 ; TT_C1707 .
GeneIDi 2774883.
KEGGi tth:TTC1707.
PATRICi 23953871. VBITheThe54392_1706.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi DPKKINA.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TTHE262724:GCAT-1740-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiFTHS_THET2
AccessioniPrimary (citable) accession number: Q72GY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3