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Q72GY6 (G6PI_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:TT_C1710
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAS82052.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Glucose-6-phosphate isomerase
PRO_0000180758

Sites

Active site2661Proton donor By similarity
Active site2921 By similarity
Active site4051 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72GY6 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: 4FA0470FE42B302C

FASTA41445,874
        10         20         30         40         50         60 
MRLDTRFLSG FPEALSRHGP LLEEARRRLL AKRGEPGSML GWMDLPEDTE TLREVRRYRE 

        70         80         90        100        110        120 
ANPWVEDFVL IGIGGSALGP KALEAAFNES GVRFHYLDHV EPEPTLRLLR TLDPRKTLVN 

       130        140        150        160        170        180 
AVSKSGSTAE TLAGLAVFLK WLKAHLGEDW RRHLVVTTDP KEGPLRAFAE REGLKAFAIP 

       190        200        210        220        230        240 
KEVGGRFSAL SPVGLLPLAF AGADLDALLM GARKANETAL APLEESLPLK TALLLHLHRH 

       250        260        270        280        290        300 
LPVHVFMVYS ERLSHLPSWF VQLHDESLGK VDRQGQRVGT TAVPALGPKD QHAQVQLFRE 

       310        320        330        340        350        360 
GPLDKLLALV IPEAPLEDVE IPEVGGLEAA SYLFGKTLFQ LLKAEAEATY EALAEAGQRV 

       370        380        390        400        410 
YALFLPEVSP YAVGWLMQHL MWQTAFLGEL WEVNAFDQPG VELGKVLTRK RLAG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017221 Genomic DNA. Translation: AAS82052.1. Different initiation.
RefSeqYP_005679.1. NC_005835.1.

3D structure databases

ProteinModelPortalQ72GY6.
SMRQ72GY6. Positions 1-414.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262724.TTC1710.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS82052; AAS82052; TT_C1710.
GeneID2776117.
KEGGtth:TTC1710.
PATRIC23953877. VBITheThe54392_1709.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMADWYRQLW.
OrthoDBEOG64R61J.
ProtClustDBCLSK738916.

Enzyme and pathway databases

BioCycTTHE262724:GCAT-1743-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_THET2
AccessionPrimary (citable) accession number: Q72GY6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways