Q72GY6 (G6PI_THET2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	TT_C1710

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.
Sequence caution	The sequence AAS82052.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180758
Sites
	Active site	266	1	Proton donor By similarity
	Active site	292	1	By similarity
	Active site	405	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q72GY6 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: 4FA0470FE42B302C	FASTA	414	45,874
	10 20 30 40 50 60 MRLDTRFLSG FPEALSRHGP LLEEARRRLL AKRGEPGSML GWMDLPEDTE TLREVRRYRE 70 80 90 100 110 120 ANPWVEDFVL IGIGGSALGP KALEAAFNES GVRFHYLDHV EPEPTLRLLR TLDPRKTLVN 130 140 150 160 170 180 AVSKSGSTAE TLAGLAVFLK WLKAHLGEDW RRHLVVTTDP KEGPLRAFAE REGLKAFAIP 190 200 210 220 230 240 KEVGGRFSAL SPVGLLPLAF AGADLDALLM GARKANETAL APLEESLPLK TALLLHLHRH 250 260 270 280 290 300 LPVHVFMVYS ERLSHLPSWF VQLHDESLGK VDRQGQRVGT TAVPALGPKD QHAQVQLFRE 310 320 330 340 350 360 GPLDKLLALV IPEAPLEDVE IPEVGGLEAA SYLFGKTLFQ LLKAEAEATY EALAEAGQRV 370 380 390 400 410 YALFLPEVSP YAVGWLMQHL MWQTAFLGEL WEVNAFDQPG VELGKVLTRK RLAG

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB27 / ATCC BAA-163 / DSM 7039.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS82052.1. Different initiation.
RefSeq	YP_005679.1. NC_005835.1.
3D structure databases
ProteinModelPortal	Q72GY6.
SMR	Q72GY6. Positions 1-414.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72GY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2776117.
GenomeReviews	Gene locus TT_C1710 in contig AE017221_GR.
PATRIC	23953877. VBITheThe54392_1709.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	CLSK738916.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C1710-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_THET2

Accession

Primary (citable) accession number: Q72GY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program