Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661Proton donorPROSITE-ProRule annotation
Active sitei292 – 2921PROSITE-ProRule annotation
Active sitei405 – 4051PROSITE-ProRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1743-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:TT_C1710
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

Cytoplasm PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Glucose-6-phosphate isomerasePRO_0000180758Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1710.

Structurei

3D structure databases

ProteinModelPortaliQ72GY6.
SMRiQ72GY6. Positions 1-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiSEHRTFV.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72GY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLDTRFLSG FPEALSRHGP LLEEARRRLL AKRGEPGSML GWMDLPEDTE
60 70 80 90 100
TLREVRRYRE ANPWVEDFVL IGIGGSALGP KALEAAFNES GVRFHYLDHV
110 120 130 140 150
EPEPTLRLLR TLDPRKTLVN AVSKSGSTAE TLAGLAVFLK WLKAHLGEDW
160 170 180 190 200
RRHLVVTTDP KEGPLRAFAE REGLKAFAIP KEVGGRFSAL SPVGLLPLAF
210 220 230 240 250
AGADLDALLM GARKANETAL APLEESLPLK TALLLHLHRH LPVHVFMVYS
260 270 280 290 300
ERLSHLPSWF VQLHDESLGK VDRQGQRVGT TAVPALGPKD QHAQVQLFRE
310 320 330 340 350
GPLDKLLALV IPEAPLEDVE IPEVGGLEAA SYLFGKTLFQ LLKAEAEATY
360 370 380 390 400
EALAEAGQRV YALFLPEVSP YAVGWLMQHL MWQTAFLGEL WEVNAFDQPG
410
VELGKVLTRK RLAG
Length:414
Mass (Da):45,874
Last modified:November 8, 2005 - v2
Checksum:i4FA0470FE42B302C
GO

Sequence cautioni

The sequence AAS82052.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82052.1. Different initiation.
RefSeqiYP_005679.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82052; AAS82052; TT_C1710.
GeneIDi2776117.
KEGGitth:TTC1710.
PATRICi23953877. VBITheThe54392_1709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82052.1. Different initiation.
RefSeqiYP_005679.1. NC_005835.1.

3D structure databases

ProteinModelPortaliQ72GY6.
SMRiQ72GY6. Positions 1-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC1710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS82052; AAS82052; TT_C1710.
GeneIDi2776117.
KEGGitth:TTC1710.
PATRICi23953877. VBITheThe54392_1709.

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiSEHRTFV.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciTTHE262724:GCAT-1743-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiG6PI_THET2
AccessioniPrimary (citable) accession number: Q72GY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: January 7, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.