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Q72GV9

- RL1_THET2

UniProt

Q72GV9 - RL1_THET2

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Protein

50S ribosomal protein L1

Gene

rplA

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.UniRule annotation
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. tRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of translation Source: UniProtKB-KW
  2. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Repressor, Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1776-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L1UniRule annotation
Gene namesi
Name:rplAUniRule annotation
Ordered Locus Names:TT_C1739
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 22922850S ribosomal protein L1PRO_0000125763Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.UniRule annotation

Structurei

Secondary structure

1
229
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 104
Turni11 – 177
Helixi24 – 329
Beta strandi36 – 383
Helixi51 – 533
Beta strandi54 – 563
Helixi82 – 876
Turni97 – 10711
Helixi119 – 1268
Turni129 – 1368
Helixi140 – 1423
Beta strandi146 – 1483
Turni149 – 1513
Helixi152 – 1598
Turni167 – 1693
Turni178 – 1803
Helixi183 – 19917
Beta strandi218 – 2203
Helixi226 – 2283

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VSAX-ray3.71A1-229[»]
1VSPX-ray3.83A1-229[»]
4BYNelectron microscopy4.30y1-229[»]
4BYQelectron microscopy4.30L1-229[»]
4KBUX-ray3.86C2-229[»]
4KBWX-ray3.86C2-229[»]
4KCZX-ray3.50C2-229[»]
4KD2X-ray3.50C2-229[»]
4KD9X-ray3.50C2-229[»]
4KDBX-ray3.50C2-229[»]
4KDHX-ray4.00C2-229[»]
4KDKX-ray4.00C2-229[»]
ProteinModelPortaliQ72GV9.
SMRiQ72GV9. Positions 2-229.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72GV9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0081.
KOiK02863.
OMAiGRYWRSI.
OrthoDBiEOG6FBX2G.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q72GV9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKHGKRYRA LLEKVDPNKI YTIDEAAHLV KELATAKFDE TVEVHAKLGI
60 70 80 90 100
DPRRSDQNVR GTVSLPHGLG KQVRVLAIAK GEKIKEAEEA GADYVGGEEI
110 120 130 140 150
IQKILDGWMD FDAVVATPDV MGAVGSKLGR ILGPRGLLPN PKAGTVGFNI
160 170 180 190 200
GEIIREIKAG RIEFRNDKTG AIHAPVGKAS FPPEKLADNI RAFIRALEAH
210 220
KPEGAKGTFL RSVYVTTTMG PSVRINPHS
Length:229
Mass (Da):24,826
Last modified:January 23, 2007 - v3
Checksum:i38C14B2563718175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82081.1.
RefSeqiYP_005708.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82081; AAS82081; TT_C1739.
GeneIDi2775643.
KEGGitth:TTC1739.
PATRICi23953943. VBITheThe54392_1738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82081.1 .
RefSeqi YP_005708.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VSA X-ray 3.71 A 1-229 [» ]
1VSP X-ray 3.83 A 1-229 [» ]
4BYN electron microscopy 4.30 y 1-229 [» ]
4BYQ electron microscopy 4.30 L 1-229 [» ]
4KBU X-ray 3.86 C 2-229 [» ]
4KBW X-ray 3.86 C 2-229 [» ]
4KCZ X-ray 3.50 C 2-229 [» ]
4KD2 X-ray 3.50 C 2-229 [» ]
4KD9 X-ray 3.50 C 2-229 [» ]
4KDB X-ray 3.50 C 2-229 [» ]
4KDH X-ray 4.00 C 2-229 [» ]
4KDK X-ray 4.00 C 2-229 [» ]
ProteinModelPortali Q72GV9.
SMRi Q72GV9. Positions 2-229.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82081 ; AAS82081 ; TT_C1739 .
GeneIDi 2775643.
KEGGi tth:TTC1739.
PATRICi 23953943. VBITheThe54392_1738.

Phylogenomic databases

eggNOGi COG0081.
KOi K02863.
OMAi GRYWRSI.
OrthoDBi EOG6FBX2G.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1776-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q72GV9.

Family and domain databases

Gene3Di 3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPi MF_01318_B. Ribosomal_L1_B.
InterProi IPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view ]
Pfami PF00687. Ribosomal_L1. 1 hit.
[Graphical view ]
PIRSFi PIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMi SSF56808. SSF56808. 1 hit.
TIGRFAMsi TIGR01169. rplA_bact. 1 hit.
PROSITEi PS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiRL1_THET2
AccessioniPrimary (citable) accession number: Q72GV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3