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Protein

50S ribosomal protein L1

Gene

rplA

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.UniRule annotation
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. tRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of translation Source: UniProtKB-KW
  2. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Repressor, Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1776-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L1UniRule annotation
Gene namesi
Name:rplAUniRule annotation
Ordered Locus Names:TT_C1739
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 22922850S ribosomal protein L1PRO_0000125763Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.UniRule annotation

Structurei

Secondary structure

1
229
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 104Combined sources
Turni11 – 177Combined sources
Helixi24 – 329Combined sources
Beta strandi36 – 383Combined sources
Helixi51 – 533Combined sources
Beta strandi54 – 563Combined sources
Helixi82 – 876Combined sources
Turni97 – 10711Combined sources
Helixi119 – 1268Combined sources
Turni129 – 1368Combined sources
Helixi140 – 1423Combined sources
Beta strandi146 – 1483Combined sources
Turni149 – 1513Combined sources
Helixi152 – 1598Combined sources
Turni167 – 1693Combined sources
Turni178 – 1803Combined sources
Helixi183 – 19917Combined sources
Beta strandi218 – 2203Combined sources
Helixi226 – 2283Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71A1-229[»]
4V4JX-ray3.83A1-229[»]
4V8Yelectron microscopy4.30L/y1-229[»]
4V9JX-ray3.86BC/DC2-229[»]
4V9KX-ray3.50BC/DC2-229[»]
4V9LX-ray3.50BC/DC2-229[»]
4V9MX-ray4.00BC/DC2-229[»]
4W29X-ray3.80BC/DC2-229[»]
ProteinModelPortaliQ72GV9.
SMRiQ72GV9. Positions 2-229.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72GV9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0081.
KOiK02863.
OMAiIQQGWFE.
OrthoDBiEOG6FBX2G.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q72GV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKHGKRYRA LLEKVDPNKI YTIDEAAHLV KELATAKFDE TVEVHAKLGI
60 70 80 90 100
DPRRSDQNVR GTVSLPHGLG KQVRVLAIAK GEKIKEAEEA GADYVGGEEI
110 120 130 140 150
IQKILDGWMD FDAVVATPDV MGAVGSKLGR ILGPRGLLPN PKAGTVGFNI
160 170 180 190 200
GEIIREIKAG RIEFRNDKTG AIHAPVGKAS FPPEKLADNI RAFIRALEAH
210 220
KPEGAKGTFL RSVYVTTTMG PSVRINPHS
Length:229
Mass (Da):24,826
Last modified:January 23, 2007 - v3
Checksum:i38C14B2563718175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82081.1.
RefSeqiYP_005708.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82081; AAS82081; TT_C1739.
KEGGitth:TTC1739.
PATRICi23953943. VBITheThe54392_1738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82081.1.
RefSeqiYP_005708.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V4IX-ray3.71A1-229[»]
4V4JX-ray3.83A1-229[»]
4V8Yelectron microscopy4.30L/y1-229[»]
4V9JX-ray3.86BC/DC2-229[»]
4V9KX-ray3.50BC/DC2-229[»]
4V9LX-ray3.50BC/DC2-229[»]
4V9MX-ray4.00BC/DC2-229[»]
4W29X-ray3.80BC/DC2-229[»]
ProteinModelPortaliQ72GV9.
SMRiQ72GV9. Positions 2-229.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS82081; AAS82081; TT_C1739.
KEGGitth:TTC1739.
PATRICi23953943. VBITheThe54392_1738.

Phylogenomic databases

eggNOGiCOG0081.
KOiK02863.
OMAiIQQGWFE.
OrthoDBiEOG6FBX2G.

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1776-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ72GV9.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiRL1_THET2
AccessioniPrimary (citable) accession number: Q72GV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.