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Q72GU1

- ODBA_THET2

UniProt

Q72GU1 - ODBA_THET2

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Protein

2-oxoisovalerate dehydrogenase subunit alpha

Gene
TT_C1757
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

Catalytic activityi

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2.By similarity

Cofactori

Thiamine pyrophosphate By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661Substrate By similarityBy similarity
Binding sitei95 – 951Substrate By similarityBy similarity
Binding sitei144 – 1441Substrate By similarityBy similarity
Metal bindingi175 – 1751Magnesium By similarityBy similarity
Metal bindingi204 – 2041Magnesium By similarityBy similarity
Metal bindingi206 – 2061Magnesium; via carbonyl oxygen By similarityBy similarity
Binding sitei273 – 2731Thiamine pyrophosphate By similarityBy similarity

GO - Molecular functioni

  1. 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1795-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoisovalerate dehydrogenase subunit alpha (EC:1.2.4.4)
Alternative name(s):
Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain
Short name:
BCKDH E1-alpha
Gene namesi
Ordered Locus Names:TT_C1757
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3673672-oxoisovalerate dehydrogenase subunit alphaPRO_0000294974Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta chains. Directly associated with ODBB in the E1 complex By similarity.By similarity

Protein-protein interaction databases

STRINGi262724.TTC1757.

Structurei

3D structure databases

ProteinModelPortaliQ72GU1.
SMRiQ72GU1. Positions 6-367.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 963Thiamine pyrophosphate binding By similarityBy similarity
Regioni128 – 1314Substrate binding By similarityBy similarity
Regioni144 – 1463Thiamine pyrophosphate binding By similarityBy similarity
Regioni174 – 1807Thiamine pyrophosphate binding By similarityBy similarity
Regioni204 – 2085Thiamine pyrophosphate binding By similarityBy similarity

Sequence similaritiesi

Belongs to the BCKDHA family.

Phylogenomic databases

eggNOGiCOG1071.
KOiK00166.
OMAiNEEWEED.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72GU1-1 [UniParc]FASTAAdd to Basket

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MVKETHRFEP FTEEPIRLIG EEGEWLGDFP LDLEGEKLRR LYRDMLAARM    50
LDERYTILIR TGKTSFIAPA AGHEAAQVAI AHAIRPGFDW VFPYYRDHGL 100
ALALGIPLKE LFGQMLATKA DPNKGRQMPE HPGSKALNFF TVASPIASHV 150
PPAAGAAISM KLLRTGQVAV CTFGDGATSE GDWYAGINFA AVQGAPAVFV 200
CENNFYAISV DYRHQTHSPT IADKAHAFGI PGYLVDGMDV LASYYVVKEA 250
VERARRGEGP SLVELRVYRY GPHSSADDDS RYRPKEEVAF WRKKDPIPRF 300
RRFLEARGLW NEEWEEDVRE EIRAELERGL KEAEEAGPVP PEWMFADVFA 350
EKPWHLLRQE ALLKEEL 367
Length:367
Mass (Da):41,442
Last modified:July 5, 2004 - v1
Checksum:i726F33C315656E49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82099.1.
RefSeqiYP_005726.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82099; AAS82099; TT_C1757.
GeneIDi2776443.
KEGGitth:TTC1757.
PATRICi23953983. VBITheThe54392_1757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82099.1 .
RefSeqi YP_005726.1. NC_005835.1.

3D structure databases

ProteinModelPortali Q72GU1.
SMRi Q72GU1. Positions 6-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82099 ; AAS82099 ; TT_C1757 .
GeneIDi 2776443.
KEGGi tth:TTC1757.
PATRICi 23953983. VBITheThe54392_1757.

Phylogenomic databases

eggNOGi COG1071.
KOi K00166.
OMAi NEEWEED.
OrthoDBi EOG6VMTKR.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1795-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiODBA_THET2
AccessioniPrimary (citable) accession number: Q72GU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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