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Q72GU1

- ODBA_THET2

UniProt

Q72GU1 - ODBA_THET2

Protein

2-oxoisovalerate dehydrogenase subunit alpha

Gene

TT_C1757

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2.By similarity

    Cofactori

    Thiamine pyrophosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661SubstrateBy similarity
    Binding sitei95 – 951SubstrateBy similarity
    Binding sitei144 – 1441SubstrateBy similarity
    Metal bindingi175 – 1751MagnesiumBy similarity
    Metal bindingi204 – 2041MagnesiumBy similarity
    Metal bindingi206 – 2061Magnesium; via carbonyl oxygenBy similarity
    Binding sitei273 – 2731Thiamine pyrophosphateBy similarity

    GO - Molecular functioni

    1. 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Magnesium, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1795-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoisovalerate dehydrogenase subunit alpha (EC:1.2.4.4)
    Alternative name(s):
    Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain
    Short name:
    BCKDH E1-alpha
    Gene namesi
    Ordered Locus Names:TT_C1757
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3673672-oxoisovalerate dehydrogenase subunit alphaPRO_0000294974Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha and two beta chains. Directly associated with ODBB in the E1 complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi262724.TTC1757.

    Structurei

    3D structure databases

    ProteinModelPortaliQ72GU1.
    SMRiQ72GU1. Positions 6-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 963Thiamine pyrophosphate bindingBy similarity
    Regioni128 – 1314Substrate bindingBy similarity
    Regioni144 – 1463Thiamine pyrophosphate bindingBy similarity
    Regioni174 – 1807Thiamine pyrophosphate bindingBy similarity
    Regioni204 – 2085Thiamine pyrophosphate bindingBy similarity

    Sequence similaritiesi

    Belongs to the BCKDHA family.Curated

    Phylogenomic databases

    eggNOGiCOG1071.
    KOiK00166.
    OMAiNEEWEED.
    OrthoDBiEOG6VMTKR.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q72GU1-1 [UniParc]FASTAAdd to Basket

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    MVKETHRFEP FTEEPIRLIG EEGEWLGDFP LDLEGEKLRR LYRDMLAARM    50
    LDERYTILIR TGKTSFIAPA AGHEAAQVAI AHAIRPGFDW VFPYYRDHGL 100
    ALALGIPLKE LFGQMLATKA DPNKGRQMPE HPGSKALNFF TVASPIASHV 150
    PPAAGAAISM KLLRTGQVAV CTFGDGATSE GDWYAGINFA AVQGAPAVFV 200
    CENNFYAISV DYRHQTHSPT IADKAHAFGI PGYLVDGMDV LASYYVVKEA 250
    VERARRGEGP SLVELRVYRY GPHSSADDDS RYRPKEEVAF WRKKDPIPRF 300
    RRFLEARGLW NEEWEEDVRE EIRAELERGL KEAEEAGPVP PEWMFADVFA 350
    EKPWHLLRQE ALLKEEL 367
    Length:367
    Mass (Da):41,442
    Last modified:July 5, 2004 - v1
    Checksum:i726F33C315656E49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS82099.1.
    RefSeqiYP_005726.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS82099; AAS82099; TT_C1757.
    GeneIDi2776443.
    KEGGitth:TTC1757.
    PATRICi23953983. VBITheThe54392_1757.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS82099.1 .
    RefSeqi YP_005726.1. NC_005835.1.

    3D structure databases

    ProteinModelPortali Q72GU1.
    SMRi Q72GU1. Positions 6-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TTC1757.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS82099 ; AAS82099 ; TT_C1757 .
    GeneIDi 2776443.
    KEGGi tth:TTC1757.
    PATRICi 23953983. VBITheThe54392_1757.

    Phylogenomic databases

    eggNOGi COG1071.
    KOi K00166.
    OMAi NEEWEED.
    OrthoDBi EOG6VMTKR.

    Enzyme and pathway databases

    BioCyci TTHE262724:GCAT-1795-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.

    Entry informationi

    Entry nameiODBA_THET2
    AccessioniPrimary (citable) accession number: Q72GU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3