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Q72GU1

- ODBA_THET2

UniProt

Q72GU1 - ODBA_THET2

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Protein

2-oxoisovalerate dehydrogenase subunit alpha

Gene

TT_C1757

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2.By similarity

Cofactori

Thiamine pyrophosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661SubstrateBy similarity
Binding sitei95 – 951SubstrateBy similarity
Binding sitei144 – 1441SubstrateBy similarity
Metal bindingi175 – 1751MagnesiumBy similarity
Metal bindingi204 – 2041MagnesiumBy similarity
Metal bindingi206 – 2061Magnesium; via carbonyl oxygenBy similarity
Binding sitei273 – 2731Thiamine pyrophosphateBy similarity

GO - Molecular functioni

  1. 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1795-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoisovalerate dehydrogenase subunit alpha (EC:1.2.4.4)
Alternative name(s):
Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain
Short name:
BCKDH E1-alpha
Gene namesi
Ordered Locus Names:TT_C1757
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3673672-oxoisovalerate dehydrogenase subunit alphaPRO_0000294974Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta chains. Directly associated with ODBB in the E1 complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi262724.TTC1757.

Structurei

3D structure databases

ProteinModelPortaliQ72GU1.
SMRiQ72GU1. Positions 6-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 963Thiamine pyrophosphate bindingBy similarity
Regioni128 – 1314Substrate bindingBy similarity
Regioni144 – 1463Thiamine pyrophosphate bindingBy similarity
Regioni174 – 1807Thiamine pyrophosphate bindingBy similarity
Regioni204 – 2085Thiamine pyrophosphate bindingBy similarity

Sequence similaritiesi

Belongs to the BCKDHA family.Curated

Phylogenomic databases

eggNOGiCOG1071.
KOiK00166.
OMAiNEEWEED.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72GU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKETHRFEP FTEEPIRLIG EEGEWLGDFP LDLEGEKLRR LYRDMLAARM
60 70 80 90 100
LDERYTILIR TGKTSFIAPA AGHEAAQVAI AHAIRPGFDW VFPYYRDHGL
110 120 130 140 150
ALALGIPLKE LFGQMLATKA DPNKGRQMPE HPGSKALNFF TVASPIASHV
160 170 180 190 200
PPAAGAAISM KLLRTGQVAV CTFGDGATSE GDWYAGINFA AVQGAPAVFV
210 220 230 240 250
CENNFYAISV DYRHQTHSPT IADKAHAFGI PGYLVDGMDV LASYYVVKEA
260 270 280 290 300
VERARRGEGP SLVELRVYRY GPHSSADDDS RYRPKEEVAF WRKKDPIPRF
310 320 330 340 350
RRFLEARGLW NEEWEEDVRE EIRAELERGL KEAEEAGPVP PEWMFADVFA
360
EKPWHLLRQE ALLKEEL
Length:367
Mass (Da):41,442
Last modified:July 5, 2004 - v1
Checksum:i726F33C315656E49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82099.1.
RefSeqiYP_005726.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82099; AAS82099; TT_C1757.
GeneIDi2776443.
KEGGitth:TTC1757.
PATRICi23953983. VBITheThe54392_1757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82099.1 .
RefSeqi YP_005726.1. NC_005835.1.

3D structure databases

ProteinModelPortali Q72GU1.
SMRi Q72GU1. Positions 6-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82099 ; AAS82099 ; TT_C1757 .
GeneIDi 2776443.
KEGGi tth:TTC1757.
PATRICi 23953983. VBITheThe54392_1757.

Phylogenomic databases

eggNOGi COG1071.
KOi K00166.
OMAi NEEWEED.
OrthoDBi EOG6VMTKR.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1795-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiODBA_THET2
AccessioniPrimary (citable) accession number: Q72GU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3