Q72GS8 (Q72GS8_THET2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine dehydrogenase PIRNR PIRNR000183
EC=1.4.1.1 PIRNR PIRNR000183

Gene names

Ordered Locus Names:

TT_C1770

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH. PIRNR PIRNR000183
Pathway	Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. PIRNR PIRNR000183
Sequence similarities	Belongs to the AlaDH/PNT family. PIRNR PIRNR000183

Ontologies

Keywords
Ligand	NAD PIRNR PIRNR000183
Molecular function	Oxidoreductase PIRNR PIRNR000183 EMBL AAS82112.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	alanine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q72GS8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FA0BBD7D4506CB2D	FASTA	369	38,647
	10 20 30 40 50 60 MVIGVPREIK TLENRVALTP GGVESLVRRG HTVLVERGAG EGSGLSDAEY ARAGAELVGR 70 80 90 100 110 120 EEAWGAEMVV KVKEPLPEEY GFLREGLILF TYLHLAADRG LTEAMLRSGV TGIAYETVQL 130 140 150 160 170 180 PDGTLPLLVP MSEVAGRMAP QVGAQFLEKP KGGRGVLLGG VPGVAPASVV ILGGGTVGTN 190 200 210 220 230 240 AAKIALGMGA QVTILDVNHK RLQYLDDVFG GRVVTLTATE ANIKKSVQHA DLLIGAVLVP 250 260 270 280 290 300 GAKAPKLVTR DMLSLMKEGA VIVDVAVDQG GCVETIRPTT HAEPTYVVDG VVHYGVANMP 310 320 330 340 350 360 GAVPRTSTFA LTNQTLPYVL KLAEKGLDAL LEDAALLKGL NTHKGRLTHP GVAEAFGLPY TPPEEALRG

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS82112.1.
RefSeq	YP_005739.1. NC_005835.1.
3D structure databases
ProteinModelPortal	Q72GS8.
SMR	Q72GS8. Positions 1-369.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72GS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2775187.
GenomeReviews	Gene locus TT_C1770 in contig AE017221_GR.
PATRIC	23954009. VBITheThe54392_1770.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0686.
HOGENOM	HBG289735.
OMA	VAHGHEV.
PhylomeDB	Q72GS8.
ProtClustDB	CLSK445306.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C1770-MONOMER.
Family and domain databases
InterPro	IPR008143. Ala_DH/PNT_CS2. IPR008141. Ala_DH/Pyr_transHydgase. IPR007886. AlaDH/PNT_N. IPR007698. AlaDH/PNT_NAD(H)-bd. [Graphical view]
PANTHER	PTHR10160:SF3. PTHR10160:SF3. 1 hit.
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
PIRSF	PIRSF000183. Alanine_dh. 1 hit.
SMART	SM01002. AlaDh_PNT_C. 1 hit. SM01003. AlaDh_PNT_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00518. AlaDH. 1 hit.
PROSITE	PS00837. ALADH_PNT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q72GS8_THET2

Accession

Primary (citable) accession number: Q72GS8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)