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Protein

50S ribosomal protein L7/L12

Gene

rplL

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L7/L12UniRule annotation
Gene namesi
Name:rplLUniRule annotation
Ordered Locus Names:TT_C1776
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002435181 – 12550S ribosomal protein L7/L12Add BLAST125

Interactioni

Subunit structurei

Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1776.

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi66 – 68Combined sources3
Turni69 – 77Combined sources9
Turni79 – 84Combined sources6
Helixi85 – 91Combined sources7
Helixi102 – 104Combined sources3
Turni106 – 108Combined sources3
Turni111 – 113Combined sources3
Beta strandi114 – 117Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V9JX-ray3.86Be/De51-122[»]
4V9KX-ray3.50Be/De51-122[»]
4V9LX-ray3.50Be/De51-122[»]
4V9MX-ray4.00Be/De51-122[»]
4W29X-ray3.80Be/De51-122[»]
ProteinModelPortaliQ72GS2.
SMRiQ72GS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial ribosomal protein bL12 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KBC. Bacteria.
COG0222. LUCA.
KOiK02935.
OMAiVDNAPKP.

Family and domain databases

CDDicd00387. Ribosomal_L7_L12. 1 hit.
Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00368. Ribosomal_L7_L12. 1 hit.
InterProiView protein in InterPro
IPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
PANTHERiPTHR24089:SF404. PTHR24089:SF404. 1 hit.
PfamiView protein in Pfam
PF00542. Ribosomal_L12. 1 hit.
PF16320. Ribosomal_L12_N. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001326. Ribosomal_L7/L12_C. 1 hit.
SUPFAMiSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.
TIGRFAMsiTIGR00855. L12. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72GS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDIERIKE ELSQATVLEL KQLIDALKEA WGVTAAAPVA VAAAPAAGAA
60 70 80 90 100
AAPAEEKTEF DVILKEAGAK KLEVIKELRA ITGLGLKEAK DLAEKGGPVK
110 120
EGVSKQEAEE IKKKLEAVGA VVELK
Length:125
Mass (Da):13,067
Last modified:July 5, 2004 - v1
Checksum:i3919CBF76605AC87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82118.1.
RefSeqiWP_008630582.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82118; AAS82118; TT_C1776.
KEGGitth:TT_C1776.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRL7_THET2
AccessioniPrimary (citable) accession number: Q72GS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families