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Protein

Peptide chain release factor 2

Gene

prfB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Biological processProtein biosynthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 2UniRule annotationSAAS annotation
Short name:
RF-2UniRule annotation
Gene namesi
Name:prfBUniRule annotation
Ordered Locus Names:TT_C1852Imported
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)Imported
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253N5-methylglutamineUniRule annotation1

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF2.UniRule annotation

Keywords - PTMi

MethylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1852

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V67X-ray3.00AX/CX1-378[»]
4V9NX-ray3.40AY/CY17-378[»]
ProteinModelPortaliQ72GJ6
SMRiQ72GJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 262RF_PROK_IInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili282 – 314Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CG1 Bacteria
COG1186 LUCA
KOiK02836
OMAiYVFHPYQ

Family and domain databases

HAMAPiMF_00094 Rel_fac_2, 1 hit
InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II
IPR004374 PrfB
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
TIGRFAMsiTIGR00020 prfB, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q72GJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLASQSAIL VKVWTWNASR NAWKASGGIF DIPQKETRLK ELERRLEDPS
60 70 80 90 100
LWNDPEAARK VSQEAARLRR TVDTFRSLES DLQGLLELME ELPAEEREAL
110 120 130 140 150
KPELEEAAKK LDELYHQTLL NFPHAEKNAI LTIQPGAGGT EACDWAEMLL
160 170 180 190 200
RMYTRFAERQ GFQVEVVDLT PGPEAGIDYA QILVKGENAY GLLSPEAGVH
210 220 230 240 250
RLVRPSPFDA SGRRHTSFAG VEVIPEVDEE VEVVLKPEEL RIDVMRASGP
260 270 280 290 300
GGQGVNTTDS AVRVVHLPTG ITVTCQTTRS QIKNKELALK ILKARLYELE
310 320 330 340 350
RKKREEELKA LRGEVRPIEW GSQIRSYVLD KNYVKDHRTG LMRHDPENVL
360 370
DGDLMDLIWA GLEWKAGRRQ GTEEVEAE
Length:378
Mass (Da):42,734
Last modified:July 5, 2004 - v1
Checksum:i55B4AC9C891AEEB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA Translation: AAS82194.1
RefSeqiWP_011174207.1, NC_005835.1

Genome annotation databases

EnsemblBacteriaiAAS82194; AAS82194; TT_C1852
KEGGitth:TT_C1852

Similar proteinsi

Entry informationi

Entry nameiQ72GJ6_THET2
AccessioniPrimary (citable) accession number: Q72GJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 31, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported