Reviewed, UniProtKB/Swiss-Prot Q72GG0 (APGM_THET2)

Names and origin

Protein names

Recommended name:
    Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
      Short name=Phosphoglyceromutase
      Short name=BPG-independent PGAM
      Short name=aPGAM
    EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	TT_C1888

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402		PRO_0000138156

Sequences

	Sequence		Length	Mass (Da)
	Q72GG0-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EFFAF2712A6BB30A	FASTA	406	44,283
	10 20 30 40 50 60 MDLFPVLKEL AQKTPSKILL IVLDGVGGLP LEPGGPTELE AAKTPNLDRL AEESALGLLT 70 80 90 100 110 120 PVYPGLAPGS GPGHLALFGY DPFRYVVGRG ALSALGLGAD FREGDVALRG NFATLDPEGK 130 140 150 160 170 180 VVDRRAGRPP TEENQRVVAK LKEAIPRIED VEVHFYTESE HRFLVVLRGE GLGDAVTDTD 190 200 210 220 230 240 PQKTGLPPLK AKALDEASER TARLVNLLSE RIREVLKDEP RMNGALFRGA SKKPSFPRMQ 250 260 270 280 290 300 EVYKLTPAAI ASYPMYKGLA SLVGMEVLPV EGEGDALEGK LKALKENWGR YDFFYFHVKK 310 320 330 340 350 360 TDAMGEDGNF HGKVEKVELF DALLPEILAL GPDVLAITGD HSTPALLKAH SWHPVPLLLK 370 380 390 400 APYLRADEAR RFTEREAQRG SLGHLRGMEL MPLLLAHAGK LLKYGA

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017221 Genomic DNA. Translation: AAS82230.1.
RefSeq	YP_005857.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q72GG0.
Genome annotation databases
GeneID	2775596.
GenomeReviews	Gene locus TT_C1888 in contig AE017221_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q72GG0.
OMA	ITGDHST.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C1888-MON.
Family and domain databases
HAMAP	MF_01402. [Tree]
InterPro	IPR004456. APGAM_arc. IPR019304. bisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
ProDom	PD004704. APGAM_DeoB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00306. apgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_THET2

Accession

Primary (citable) accession number: Q72GG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)