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Q72GF3 (Q72GF3_THET2) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Ordered Locus Names:TT_C1895 EMBL AAS82237.1
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP] EMBL AAS82237.1
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the DEAD box helicase family. RuleBase RU000492

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding56 – 594AMP PDB 4KBF
Region55 – 595Sulfate 1 binding PDB 4KBG
Region134 – 1374Sulfate 2 binding PDB 3MWK PDB 3MWL PDB 3MWJ

Sites

Metal binding541Sodium PDB 4KBF
Metal binding2171Sodium; via carbonyl oxygen PDB 4KBF
Metal binding2191Sodium PDB 4KBF
Binding site301AMP; via carbonyl oxygen PDB 4KBF
Binding site351AMP PDB 4KBF
Binding site891Sulfate 2 PDB 3MWK PDB 3MWL PDB 3MWJ
Binding site1071Sulfate 3 PDB 3MWK PDB 3MWL PDB 3MWJ
Binding site1131Sulfate 2; via amide nitrogen PDB 3MWK PDB 3MWL PDB 3MWJ
Binding site1261Sulfate 3 PDB 3MWK PDB 3MWL PDB 3MWJ
Binding site4991Chloride; via amide nitrogen PDB 4I68

Sequences

Sequence LengthMass (Da)Tools
Q72GF3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 83B1412150CEF34A

FASTA51756,738
        10         20         30         40         50         60 
MGPERQSMEF KDFPLKPEIL EALHGRGLTT PTPIQAAALP LALEGKDLIG QARTGTGKTL 

        70         80         90        100        110        120 
AFALPIAERL APSQERGRKP RALVLTPTRE LALQVASELT AVAPHLKVVA VYGGTGYGKQ 

       130        140        150        160        170        180 
KEALLRGADA VVATPGRALD YLRQGVLDLS RVEVAVLDEA DEMLSMGFEE EVEALLSATP 

       190        200        210        220        230        240 
PSRQTLLFSA TLPSWAKRLA ERYMKNPVLI NVIKDEPVTY EEEAVPAPVR GRLEVLSDLL 

       250        260        270        280        290        300 
YVASPDRAMV FTRTKAETEE IAQGLLRLGH PAQALHGDLS QGERERVLGA FRQGEVRVLV 

       310        320        330        340        350        360 
ATDVAARGLD IPQVDLVVHY RLPDRAEAYQ HRSGRTGRAG RGGRVVLLYG PRERRDVEAL 

       370        380        390        400        410        420 
ERAVGRRFKR VNPPTPEEVL EAKWRHLLAR LARVPEKDYR LYQDFAGRLF AEGRVEVVAA 

       430        440        450        460        470        480 
LLALLLGGAP AERSLLTGEE GWRTYKATGP RLSLPRLVAL LKGQGLEVGK VAEAEGGFYV 

       490        500        510 
DLRPEARPEV AGLRLEPARR VEGLLEIPSR TRRPARA 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of the extreme thermophile Thermus thermophilus."
Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Overbeek R., Kramer W. expand/collapse author list , Merkl R., Gottschalk G., Fritz H.-J.
Nat. Biotechnol. 22:547-553(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB27 / ATCC BAA-163 / DSM 7039.
[2]"A novel dimerization motif in the C-terminal domain of the Thermus thermophilus DEAD box helicase Hera confers substantial flexibility."
Klostermeier D., Rudolph M.G.
Nucleic Acids Res. 37:421-430(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 215-426.
[3]"The Thermus thermophilus DEAD box helicase Hera contains a modified RNA recognition motif domain loosely connected to the helicase core."
Rudolph M.G., Klostermeier D.
RNA 15:1993-2001(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 431-517.
[4]"Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop."
Strohmeier J., Hertel I., Diederichsen U., Rudolph M.G., Klostermeier D.
Biol. Chem. 392:357-369(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 8-214 IN COMPLEX WITH SULFATE.
[5]"Rearranging RNA structures at 75?C? toward the molecular mechanism and physiological function of the thermus thermophilus DEAD-box helicase hera."
Klostermeier D.
Biopolymers 99:1137-1146(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 8-372 IN COMPLEX WITH AMP; SODIUM AND SULFATE.
[6]"Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera."
Steimer L., Wurm J.P., Linden M.H., Rudolph M.G., Wohnert J., Klostermeier D.
Nucleic Acids Res. 41:6259-6272(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 431-517 IN COMPLEX WITH CHLORIDE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017221 Genomic DNA. Translation: AAS82237.1.
RefSeqYP_005864.1. NC_005835.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3EAQX-ray2.30A/B215-426[»]
3EARX-ray2.30A/B215-426[»]
3EASX-ray2.80A/B215-426[»]
3I31X-ray1.80A431-517[»]
3I32X-ray2.80A218-517[»]
3MWJX-ray1.40A/B8-214[»]
3MWKX-ray1.45A/B8-214[»]
3MWLX-ray1.60A/B8-214[»]
3NBFX-ray1.90A/B/C/D8-214[»]
3NEJX-ray2.57A/B8-214[»]
4I67X-ray2.33A431-517[»]
4I68X-ray1.63A431-517[»]
4I69X-ray1.79A/B/C431-517[»]
4KBFX-ray1.90A/B8-372[»]
4KBGX-ray2.54A/B8-372[»]
ProteinModelPortalQ72GF3.
SMRQ72GF3. Positions 8-214.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS82237; AAS82237; TT_C1895.
GeneID2774568.
KEGGtth:TTC1895.
PATRIC23954257. VBITheThe54392_1891.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0513.
OMAHLPQDPE.
OrthoDBEOG6GBMBM.

Enzyme and pathway databases

BioCycTTHE262724:GCAT-1936-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ72GF3.

Entry information

Entry nameQ72GF3_THET2
AccessionPrimary (citable) accession number: Q72GF3
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)