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Q72GF3

- Q72GF3_THET2

UniProt

Q72GF3 - Q72GF3_THET2

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Protein
Submitted name:

Heat resistant RNA dependent ATPase

Gene

TT_C1895

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301AMP; via carbonyl oxygenImported
Binding sitei35 – 351AMPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 594AMPImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotation, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1936-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Heat resistant RNA dependent ATPaseImported
Gene namesi
Ordered Locus Names:TT_C1895Imported
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)Imported
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EAQX-ray2.30A/B215-426[»]
3EARX-ray2.30A/B215-426[»]
3EASX-ray2.80A/B215-426[»]
3I31X-ray1.80A431-517[»]
3I32X-ray2.80A218-517[»]
3MWJX-ray1.40A/B8-214[»]
3MWKX-ray1.45A/B8-214[»]
3MWLX-ray1.60A/B8-214[»]
3NBFX-ray1.90A/B/C/D8-214[»]
3NEJX-ray2.57A/B8-214[»]
4I67X-ray2.33A431-517[»]
4I68X-ray1.63A431-517[»]
4I69X-ray1.79A/B/C431-517[»]
4KBFX-ray1.90A/B8-372[»]
4KBGX-ray2.54A/B8-372[»]
ProteinModelPortaliQ72GF3.
SMRiQ72GF3. Positions 8-214.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72GF3.

Family & Domainsi

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0513.
OMAiHLPQDPE.
OrthoDBiEOG6GBMBM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72GF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPERQSMEF KDFPLKPEIL EALHGRGLTT PTPIQAAALP LALEGKDLIG
60 70 80 90 100
QARTGTGKTL AFALPIAERL APSQERGRKP RALVLTPTRE LALQVASELT
110 120 130 140 150
AVAPHLKVVA VYGGTGYGKQ KEALLRGADA VVATPGRALD YLRQGVLDLS
160 170 180 190 200
RVEVAVLDEA DEMLSMGFEE EVEALLSATP PSRQTLLFSA TLPSWAKRLA
210 220 230 240 250
ERYMKNPVLI NVIKDEPVTY EEEAVPAPVR GRLEVLSDLL YVASPDRAMV
260 270 280 290 300
FTRTKAETEE IAQGLLRLGH PAQALHGDLS QGERERVLGA FRQGEVRVLV
310 320 330 340 350
ATDVAARGLD IPQVDLVVHY RLPDRAEAYQ HRSGRTGRAG RGGRVVLLYG
360 370 380 390 400
PRERRDVEAL ERAVGRRFKR VNPPTPEEVL EAKWRHLLAR LARVPEKDYR
410 420 430 440 450
LYQDFAGRLF AEGRVEVVAA LLALLLGGAP AERSLLTGEE GWRTYKATGP
460 470 480 490 500
RLSLPRLVAL LKGQGLEVGK VAEAEGGFYV DLRPEARPEV AGLRLEPARR
510
VEGLLEIPSR TRRPARA
Length:517
Mass (Da):56,738
Last modified:July 5, 2004 - v1
Checksum:i83B1412150CEF34A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82237.1.
RefSeqiYP_005864.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82237; AAS82237; TT_C1895.
GeneIDi2774568.
KEGGitth:TTC1895.
PATRICi23954257. VBITheThe54392_1891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82237.1 .
RefSeqi YP_005864.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EAQ X-ray 2.30 A/B 215-426 [» ]
3EAR X-ray 2.30 A/B 215-426 [» ]
3EAS X-ray 2.80 A/B 215-426 [» ]
3I31 X-ray 1.80 A 431-517 [» ]
3I32 X-ray 2.80 A 218-517 [» ]
3MWJ X-ray 1.40 A/B 8-214 [» ]
3MWK X-ray 1.45 A/B 8-214 [» ]
3MWL X-ray 1.60 A/B 8-214 [» ]
3NBF X-ray 1.90 A/B/C/D 8-214 [» ]
3NEJ X-ray 2.57 A/B 8-214 [» ]
4I67 X-ray 2.33 A 431-517 [» ]
4I68 X-ray 1.63 A 431-517 [» ]
4I69 X-ray 1.79 A/B/C 431-517 [» ]
4KBF X-ray 1.90 A/B 8-372 [» ]
4KBG X-ray 2.54 A/B 8-372 [» ]
ProteinModelPortali Q72GF3.
SMRi Q72GF3. Positions 8-214.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82237 ; AAS82237 ; TT_C1895 .
GeneIDi 2774568.
KEGGi tth:TTC1895.
PATRICi 23954257. VBITheThe54392_1891.

Phylogenomic databases

eggNOGi COG0513.
OMAi HLPQDPE.
OrthoDBi EOG6GBMBM.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1936-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q72GF3.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039Imported.
  2. "A novel dimerization motif in the C-terminal domain of the Thermus thermophilus DEAD box helicase Hera confers substantial flexibility."
    Klostermeier D., Rudolph M.G.
    Nucleic Acids Res. 37:421-430(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 215-426.
  3. "The Thermus thermophilus DEAD box helicase Hera contains a modified RNA recognition motif domain loosely connected to the helicase core."
    Rudolph M.G., Klostermeier D.
    RNA 15:1993-2001(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 431-517.
  4. "Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop."
    Strohmeier J., Hertel I., Diederichsen U., Rudolph M.G., Klostermeier D.
    Biol. Chem. 392:357-369(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 8-214.
  5. "Rearranging RNA structures at 75?C? toward the molecular mechanism and physiological function of the thermus thermophilus DEAD-box helicase hera."
    Klostermeier D.
    Biopolymers 99:1137-1146(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 8-372 IN COMPLEX WITH AMP.
  6. "Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera."
    Steimer L., Wurm J.P., Linden M.H., Rudolph M.G., Wohnert J., Klostermeier D.
    Nucleic Acids Res. 41:6259-6272(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 431-517.

Entry informationi

Entry nameiQ72GF3_THET2
AccessioniPrimary (citable) accession number: Q72GF3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3