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Q72GA4

- Q72GA4_THET2

UniProt

Q72GA4 - Q72GA4_THET2

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Protein
Alanine racemase
Gene
TT_C1944
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei142 – 1421Substrate By similarityUniRule annotation
Active sitei257 – 2571Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1988-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TT_C1944Imported
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)Imported
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1944.

Structurei

3D structure databases

ProteinModelPortaliQ72GA4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
KOiK01775.
OMAiKIYFVCK.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72GA4-1 [UniParc]FASTAAdd to Basket

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MPAGPIGLVE VEERAWVEVD LAALWANYRL LAGRAGGEVI PVLKADAYGH    50
GALPLARFLE GKGVGRFAVA TLEEGRRLRE GGIKGEVLLL GSLHPLEAEE 100
ALELGLVPTL STLEAAEALS QRARALGLVP RAHLKVDTGM NRVGFPWEEA 150
ASALRAVEAL GVRVEGVYTH LATAGEDAAF VETQRRRFQE VRRALGEGYF 200
YHLENSLGLL RHGATAGVRV GLALYGLVPG FGLRPILRIL ARPTLVKRLK 250
AGDRVGYGGV YVARGGEWLA TLPVGYADGL PWGAVRFVKG PDGRLLEVAG 300
RISMDQTTVL LPGPVGLEAV FEVLSADFGP TGLLAWAEAR GTLPYEVAVH 350
LSRRLPRRYL E 361
Length:361
Mass (Da):38,763
Last modified:July 5, 2004 - v1
Checksum:iC6B73A8AAE9310EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82286.1.
RefSeqiYP_005913.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82286; AAS82286; TT_C1944.
GeneIDi2775347.
KEGGitth:TTC1944.
PATRICi23954357. VBITheThe54392_1938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82286.1 .
RefSeqi YP_005913.1. NC_005835.1.

3D structure databases

ProteinModelPortali Q72GA4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1944.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82286 ; AAS82286 ; TT_C1944 .
GeneIDi 2775347.
KEGGi tth:TTC1944.
PATRICi 23954357. VBITheThe54392_1938.

Phylogenomic databases

eggNOGi COG0787.
KOi K01775.
OMAi KIYFVCK.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TTHE262724:GCAT-1988-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiQ72GA4_THET2
AccessioniPrimary (citable) accession number: Q72GA4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi