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Q72GA4

- Q72GA4_THET2

UniProt

Q72GA4 - Q72GA4_THET2

Protein

Alanine racemase

Gene

TT_C1944

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation
    Active sitei257 – 2571Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1988-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:TT_C1944Imported
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)Imported
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi262724.TTC1944.

    Structurei

    3D structure databases

    ProteinModelPortaliQ72GA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    KOiK01775.
    OMAiKIYFVCK.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q72GA4-1 [UniParc]FASTAAdd to Basket

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    MPAGPIGLVE VEERAWVEVD LAALWANYRL LAGRAGGEVI PVLKADAYGH    50
    GALPLARFLE GKGVGRFAVA TLEEGRRLRE GGIKGEVLLL GSLHPLEAEE 100
    ALELGLVPTL STLEAAEALS QRARALGLVP RAHLKVDTGM NRVGFPWEEA 150
    ASALRAVEAL GVRVEGVYTH LATAGEDAAF VETQRRRFQE VRRALGEGYF 200
    YHLENSLGLL RHGATAGVRV GLALYGLVPG FGLRPILRIL ARPTLVKRLK 250
    AGDRVGYGGV YVARGGEWLA TLPVGYADGL PWGAVRFVKG PDGRLLEVAG 300
    RISMDQTTVL LPGPVGLEAV FEVLSADFGP TGLLAWAEAR GTLPYEVAVH 350
    LSRRLPRRYL E 361
    Length:361
    Mass (Da):38,763
    Last modified:July 5, 2004 - v1
    Checksum:iC6B73A8AAE9310EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS82286.1.
    RefSeqiYP_005913.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS82286; AAS82286; TT_C1944.
    GeneIDi2775347.
    KEGGitth:TTC1944.
    PATRICi23954357. VBITheThe54392_1938.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS82286.1 .
    RefSeqi YP_005913.1. NC_005835.1.

    3D structure databases

    ProteinModelPortali Q72GA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TTC1944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS82286 ; AAS82286 ; TT_C1944 .
    GeneIDi 2775347.
    KEGGi tth:TTC1944.
    PATRICi 23954357. VBITheThe54392_1938.

    Phylogenomic databases

    eggNOGi COG0787.
    KOi K01775.
    OMAi KIYFVCK.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TTHE262724:GCAT-1988-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039Imported.

    Entry informationi

    Entry nameiQ72GA4_THET2
    AccessioniPrimary (citable) accession number: Q72GA4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3