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Q72GA4 (Q72GA4_THET2) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase HAMAP MF_01201
EC=5.1.1.1 HAMAP MF_01201
Gene names
Name:alr HAMAP MF_01201
Ordered Locus Names:TT_C1944
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_01201 SAAS SAAS009006

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site441Proton acceptor; specific for D-alanine By similarity HAMAP MF_01201
Active site2571Proton acceptor; specific for L-alanine By similarity HAMAP MF_01201

Amino acid modifications

Modified residue441N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_01201

Sequences

Sequence LengthMass (Da)Tools
Q72GA4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C6B73A8AAE9310EB

FASTA36138,763
        10         20         30         40         50         60 
MPAGPIGLVE VEERAWVEVD LAALWANYRL LAGRAGGEVI PVLKADAYGH GALPLARFLE 

        70         80         90        100        110        120 
GKGVGRFAVA TLEEGRRLRE GGIKGEVLLL GSLHPLEAEE ALELGLVPTL STLEAAEALS 

       130        140        150        160        170        180 
QRARALGLVP RAHLKVDTGM NRVGFPWEEA ASALRAVEAL GVRVEGVYTH LATAGEDAAF 

       190        200        210        220        230        240 
VETQRRRFQE VRRALGEGYF YHLENSLGLL RHGATAGVRV GLALYGLVPG FGLRPILRIL 

       250        260        270        280        290        300 
ARPTLVKRLK AGDRVGYGGV YVARGGEWLA TLPVGYADGL PWGAVRFVKG PDGRLLEVAG 

       310        320        330        340        350        360 
RISMDQTTVL LPGPVGLEAV FEVLSADFGP TGLLAWAEAR GTLPYEVAVH LSRRLPRRYL 


E

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References

[1]"The genome sequence of the extreme thermophile Thermus thermophilus."
Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J.
Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017221 Genomic DNA. Translation: AAS82286.1.
RefSeqYP_005913.1. NC_005835.1.

3D structure databases

HSSPHSSP built from PDB template 1BD0 based on UniProtKB P10724.
ProteinModelPortalQ72GA4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ72GA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2775347.
GenomeReviewsGene locus TT_C1944 in contig AE017221_GR.
PATRIC23954357. VBITheThe54392_1938.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHBG712172.
OMAIPELEGC.
PhylomeDBQ72GA4.
ProtClustDBCLSK738977.

Enzyme and pathway databases

BioCycTTHE262724:TT_C1944-MONOMER.

Family and domain databases

HAMAPMF_01201. Ala_racemase.
[Tree]
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR00492. Alr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ72GA4_THET2
AccessionPrimary (citable) accession number: Q72GA4
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info