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Protein

Alanine racemase

Gene

TT_C1944

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (TT_C1944)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Active sitei257Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei304Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TT_C1944Imported
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)Imported
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1944.

Structurei

3D structure databases

ProteinModelPortaliQ72GA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini236 – 360Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
KOiK01775.
OMAiWEILCGF.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72GA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGPIGLVE VEERAWVEVD LAALWANYRL LAGRAGGEVI PVLKADAYGH
60 70 80 90 100
GALPLARFLE GKGVGRFAVA TLEEGRRLRE GGIKGEVLLL GSLHPLEAEE
110 120 130 140 150
ALELGLVPTL STLEAAEALS QRARALGLVP RAHLKVDTGM NRVGFPWEEA
160 170 180 190 200
ASALRAVEAL GVRVEGVYTH LATAGEDAAF VETQRRRFQE VRRALGEGYF
210 220 230 240 250
YHLENSLGLL RHGATAGVRV GLALYGLVPG FGLRPILRIL ARPTLVKRLK
260 270 280 290 300
AGDRVGYGGV YVARGGEWLA TLPVGYADGL PWGAVRFVKG PDGRLLEVAG
310 320 330 340 350
RISMDQTTVL LPGPVGLEAV FEVLSADFGP TGLLAWAEAR GTLPYEVAVH
360
LSRRLPRRYL E
Length:361
Mass (Da):38,763
Last modified:July 5, 2004 - v1
Checksum:iC6B73A8AAE9310EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82286.1.
RefSeqiWP_011174295.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82286; AAS82286; TT_C1944.
KEGGitth:TT_C1944.

Similar proteinsi

Entry informationi

Entry nameiQ72GA4_THET2
AccessioniPrimary (citable) accession number: Q72GA4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported