Q72G68 (GLGA_THET2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycogen synthase
EC=2.4.1.21

Alternative name(s):
Starch [bacterial glycogen] synthase

Gene names

Name:	glgA
Ordered Locus Names:	TT_C1980

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › Thermus thermophilus

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesizes alpha-1,4-glucan chains using ADP-glucose By similarity. HAMAP-Rule MF_00484
Catalytic activity	ADP-glucose + (1,4-alpha-D-glucosyl)(n) = ADP + (1,4-alpha-D-glucosyl)(n+1). HAMAP-Rule MF_00484
Pathway	Glycan biosynthesis; glycogen biosynthesis. HAMAP-Rule MF_00484
Sequence similarities	Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Sequence caution	The sequence AAS82322.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Glycogen biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycogen biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	starch synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Glycogen synthase HAMAP-Rule MF_00484		PRO_0000230267
Sites
	Binding site	15	1	ADP-glucose By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q72G68 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: B2C52E0E6745B843	FASTA	437	48,174
	10 20 30 40 50 60 MRVLHVAPEA YPLAKVGGLA DVVGALPKAL GPLGVEAHVL LPWHGGLEAR RVGEVAFAFF 70 80 90 100 110 120 GREERAPLGE RVEGGVRFLL LGVEGFGRER VYGYPDDAER YLRFALAAKE VARGYDLVHA 130 140 150 160 170 180 HDWTAALLAL YAPTVYTIHN LAHQGLVDPG LFFSWTGLPW SLFHMEALEF YGRVNLMKGG 190 200 210 220 230 240 IVFARRVTTV SPSYAEEIQT PEFGMGLDGV LRRHAGKLRG ILNGLDTEVF DPGKDPYLPA 250 260 270 280 290 300 PYTREDPSGK ARAKEAFRER TGLRPPVLAY VGRLDYQKGL DLVLKALPRL LEMGFRLYVQ 310 320 330 340 350 360 GVGDGGLQEA FLRAEEENPE GVRFLPAYDE AMARLAYAGA EAVLVPSRFE PCGLVQMIAS 370 380 390 400 410 420 RYGTPPVARA VGGLKDTVED GRAGVLFETY HPEGLLYGVL RLFRLGAEEM GLRAMEKDFS 430 WEGPARAYRE VYREALG

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB27 / ATCC BAA-163 / DSM 7039.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS82322.1. Different initiation.
RefSeq	YP_005949.1. NC_005835.1.
3D structure databases
ProteinModelPortal	Q72G68.
ModBase	Search...
Protein-protein interaction databases
STRING	262724.TTC1980.
Protein family/group databases
CAZy	GT5. Glycosyltransferase Family 5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS82322; AAS82322; TT_C1980.
GeneID	2775696.
KEGG	tth:TTC1980.
PATRIC	23954427. VBITheThe54392_1973.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0297.
KO	K00703.
OMA	FDTVGWA.
ProtClustDB	CLSK738392.
Enzyme and pathway databases
UniPathway	UPA00164.
Family and domain databases
HAMAP	MF_00484. Glycogen_synth.
InterPro	IPR001296. Glyco_trans_1. IPR011835. Glycogen/starch_synth. IPR013534. Starch_synth_cat_dom. [Graphical view]
Pfam	PF08323. Glyco_transf_5. 1 hit. PF00534. Glycos_transf_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR02095. glgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLGA_THET2

Accession

Primary (citable) accession number: Q72G68

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program