Reviewed, UniProtKB/Swiss-Prot Q72G53 (SYN_DESVH)

Names and origin

Protein names

Recommended name:
    Asparaginyl-tRNA synthetase
    EC=6.1.1.22
Alternative name(s):
    Asparagine--tRNA ligase
      Short name=AsnRS

Gene names

Name:	asnS
Ordered Locus Names:	DVU_0007

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Complete proteome] [HAMAP]

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00534
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP asparagine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Asparaginyl-tRNA synthetase HAMAP MF_00534		PRO_0000176405

Sequences

	Sequence		Length	Mass (Da)
	Q72G53-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 372073C9E0C2176D	FASTA	461	51,912
	10 20 30 40 50 60 MQRTQIVDAL AATAPQPVIR LCGWVRTRRD AKGFSFLEIN DGSCLANIQA IVDEGIPAYA 70 80 90 100 110 120 NIGAVSTGAA VDITGELVES PGKGQKWEVR VQTLTLLGAA DAETYPLQKK RHSDEFLRSI 130 140 150 160 170 180 AHLRARTNKY GAAFRIRSEA AFAIHEFYRE RGFFYVHTPI LTGSDCEGAG EMFRVTTLPV 190 200 210 220 230 240 EGSATPASGN RYENDFFGKE CNLTVSGQLE AETLALGLGK VYTFGPTFRA ENSNTPRHAA 250 260 270 280 290 300 EFWMIEPEVA FADLEEDMNL AEDMTRTVVR RILDRCAADL DLFNRFVDTT LVERLRQIAD 310 320 330 340 350 360 EPFARCSYTE AIELLLKSGK KFEYPVSFGL DLQTEHERYL AEEHFGKPVI VYNYPKEIKA 370 380 390 400 410 420 FYMRLNDDGR TVAAMDVLVP RIGELIGGSQ REERLDVLEA RINEMGQNLE DYWWYLDLRR 430 440 450 460 FGSVPHAGFG MGFERLLMLL TGITNIRDVI PFPRTPGNLE F

References

[1]

"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D.E. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed: 15077118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017285 Genomic DNA. Translation: AAS94491.1.
RefSeq	YP_009232.1.
3D structure databases
HSSP	HSSP built from PDB template 1BBW based on UniProtKB P13030.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72G53.
Genome annotation databases
GeneID	2793559.
GenomeReviews	Gene locus DVU_0007 in contig AE017285_GR.
KEGG	dvu:DVU0007.
NMPDR	fig|882.1.peg.7.
TIGR	DVU_0007.
Phylogenomic databases
HOGENOM	Q72G53.
OMA	LQKKRHS.
Enzyme and pathway databases
BioCyc	DVUL882:DVU_0007-MON.
Family and domain databases
HAMAP	MF_00534. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00457. asnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYN_DESVH

Accession

Primary (citable) accession number: Q72G53

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)