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Q72F80 (DDL_DESVH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:DVU_0334
OrganismDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]
Taxonomic identifier882 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000030446

Regions

Domain100 – 295196ATP-grasp
Nucleotide binding127 – 18054ATP By similarity

Sites

Metal binding2491Magnesium or manganese 1 By similarity
Metal binding2621Magnesium or manganese 1 By similarity
Metal binding2621Magnesium or manganese 2 By similarity
Metal binding2641Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72F80 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9CEA596D721EBBD0

FASTA30331,659
        10         20         30         40         50         60 
MKVLLIAGGW SSERDVSLAG ARGIEKALCA LGHDVTWFDP ATSLDGLLEA ASSHDFAFIN 

        70         80         90        100        110        120 
LHGSPGEDGL VQAMLDTAGC PYQGSGPAGS FLALNKAVSK QLLRRHGILT PDWAFLAARP 

       130        140        150        160        170        180 
AADWEPGLGY PLFVKPNTGG SSLCLSRVTQ PEGLAPALEA VFAHCGEAIV EPAIPGVEVT 

       190        200        210        220        230        240 
CGVLGDTALP PILIRPAEGA FFDYTSKYTP GGATELCPAP LPAEVTAHVQ DVTLRAHRLL 

       250        260        270        280        290        300 
GLRGYSRADY ILRDDGALFL LEVNTLPGMT PTSLVPQEAA AIGLDFPALI ARLIELGMTA 


AGR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017285 Genomic DNA. Translation: AAS94817.1.
RefSeqYP_009558.1. NC_002937.3.

3D structure databases

ProteinModelPortalQ72F80.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING882.DVU0334.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS94817; AAS94817; DVU_0334.
GeneID2794750.
KEGGdvu:DVU0334.
PATRIC32060640. VBIDesVul119526_0315.

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OMAKYTEGFA.
OrthoDBEOG6ND0KB.
ProtClustDBCLSK704556.

Enzyme and pathway databases

BioCycDVUL882:GJIL-352-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_DESVH
AccessionPrimary (citable) accession number: Q72F80
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways