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Q72ER6

- PNP_DESVH

UniProt

Q72ER6 - PNP_DESVH

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, DVU_0503
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi492 – 4921Magnesium By similarity
Metal bindingi498 – 4981Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDVUL882:GJIL-524-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:DVU_0503
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329626Add
BLAST

Proteomic databases

PRIDEiQ72ER6.

Interactioni

Protein-protein interaction databases

STRINGi882.DVU0503.

Structurei

3D structure databases

ProteinModelPortaliQ72ER6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini559 – 61860KH
Add
BLAST
Domaini628 – 70275S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.
PhylomeDBiQ72ER6.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72ER6-1 [UniParc]FASTAAdd to Basket

« Hide

MTNIFNAMRV TATVGGKEIV FETGRLANQA DGAVWIQCGG TVVLVTACSQ    50
ATDRDLGFFP LTVEYSEKMY AAGRIPGSFF RREIGRPSER ETLVSRLIDR 100
PIRPLFPKGL KDEVQVLANV ISSDQNNDSD VLAVTGASTA LGLSSIPFDG 150
PVAGARIGRI DGQFVINPTI KEMERSDLNI VLAASRDAVV MVEGEASFVP 200
EAVIVEALEW GHKEIQPLID AQLKLREMAG KAKREFTAPV EDADLAARVA 250
ALATADLDVA LRIPEKMARK DARKAVKEKV MEALVADPAY AEDTTPLRAV 300
GDILSALEKR IVRERIVREG RRIDGRDTTT VRPILIEAGI LPRAHGSALF 350
ARGETKSLVV ATLGSSTDEQ RMDSLTGDVT KRFMLHYNFA PYCVGEVKPV 400
RVSRREIGHG ALAEKALRPI LPLGEDFPFT LRVVAETMES NGSSSMAAVC 450
GGCLSLMDAG VPITAPVAGV AMGLIKEGDQ YVVLTDILGD EDALGDMDFK 500
IAGTSEGITA VQMDIKVKGL PTDVMARAMQ QARDARLHIL GEMGKVLEAP 550
RAELSAYAPQ HAEVFVNPDI IRIIIGPGGK NIKAITATTG ASIDIEDSGR 600
VSIFAPTLEA MEMAREMVQY YDQRADIGKN YTGKVRKVLE IGAIVEILPN 650
LEALVHISQL DTNRVEQASD VARLGEDMVV KVIEINGDRI RASRKAVLLE 700
EQGIEWKPED TARPSGPREG GRRDGGRDGR RDGGRDGRRD GGRDGGRRDG 750
GRRDGGRDRN 760
Length:760
Mass (Da):82,199
Last modified:July 5, 2004 - v1
Checksum:i5F4C773F580B1515
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS94985.1.
RefSeqiYP_009726.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS94985; AAS94985; DVU_0503.
GeneIDi2796763.
KEGGidvu:DVU0503.
PATRICi32060976. VBIDesVul119526_0480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS94985.1 .
RefSeqi YP_009726.1. NC_002937.3.

3D structure databases

ProteinModelPortali Q72ER6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU0503.

Proteomic databases

PRIDEi Q72ER6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS94985 ; AAS94985 ; DVU_0503 .
GeneIDi 2796763.
KEGGi dvu:DVU0503.
PATRICi 32060976. VBIDesVul119526_0480.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.
PhylomeDBi Q72ER6.

Enzyme and pathway databases

BioCyci DVUL882:GJIL-524-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiPNP_DESVH
AccessioniPrimary (citable) accession number: Q72ER6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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