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Q72ER6

- PNP_DESVH

UniProt

Q72ER6 - PNP_DESVH

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi492 – 4921MagnesiumUniRule annotation
Metal bindingi498 – 4981MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDVUL882:GJIL-524-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:DVU_0503
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Polyribonucleotide nucleotidyltransferasePRO_0000329626Add
BLAST

Proteomic databases

PRIDEiQ72ER6.

Interactioni

Protein-protein interaction databases

STRINGi882.DVU0503.

Structurei

3D structure databases

ProteinModelPortaliQ72ER6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini559 – 61860KHUniRule annotationAdd
BLAST
Domaini628 – 70275S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.
PhylomeDBiQ72ER6.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72ER6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNIFNAMRV TATVGGKEIV FETGRLANQA DGAVWIQCGG TVVLVTACSQ
60 70 80 90 100
ATDRDLGFFP LTVEYSEKMY AAGRIPGSFF RREIGRPSER ETLVSRLIDR
110 120 130 140 150
PIRPLFPKGL KDEVQVLANV ISSDQNNDSD VLAVTGASTA LGLSSIPFDG
160 170 180 190 200
PVAGARIGRI DGQFVINPTI KEMERSDLNI VLAASRDAVV MVEGEASFVP
210 220 230 240 250
EAVIVEALEW GHKEIQPLID AQLKLREMAG KAKREFTAPV EDADLAARVA
260 270 280 290 300
ALATADLDVA LRIPEKMARK DARKAVKEKV MEALVADPAY AEDTTPLRAV
310 320 330 340 350
GDILSALEKR IVRERIVREG RRIDGRDTTT VRPILIEAGI LPRAHGSALF
360 370 380 390 400
ARGETKSLVV ATLGSSTDEQ RMDSLTGDVT KRFMLHYNFA PYCVGEVKPV
410 420 430 440 450
RVSRREIGHG ALAEKALRPI LPLGEDFPFT LRVVAETMES NGSSSMAAVC
460 470 480 490 500
GGCLSLMDAG VPITAPVAGV AMGLIKEGDQ YVVLTDILGD EDALGDMDFK
510 520 530 540 550
IAGTSEGITA VQMDIKVKGL PTDVMARAMQ QARDARLHIL GEMGKVLEAP
560 570 580 590 600
RAELSAYAPQ HAEVFVNPDI IRIIIGPGGK NIKAITATTG ASIDIEDSGR
610 620 630 640 650
VSIFAPTLEA MEMAREMVQY YDQRADIGKN YTGKVRKVLE IGAIVEILPN
660 670 680 690 700
LEALVHISQL DTNRVEQASD VARLGEDMVV KVIEINGDRI RASRKAVLLE
710 720 730 740 750
EQGIEWKPED TARPSGPREG GRRDGGRDGR RDGGRDGRRD GGRDGGRRDG
760
GRRDGGRDRN
Length:760
Mass (Da):82,199
Last modified:July 5, 2004 - v1
Checksum:i5F4C773F580B1515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA. Translation: AAS94985.1.
RefSeqiYP_009726.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS94985; AAS94985; DVU_0503.
GeneIDi2796763.
KEGGidvu:DVU0503.
PATRICi32060976. VBIDesVul119526_0480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA. Translation: AAS94985.1 .
RefSeqi YP_009726.1. NC_002937.3.

3D structure databases

ProteinModelPortali Q72ER6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU0503.

Proteomic databases

PRIDEi Q72ER6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS94985 ; AAS94985 ; DVU_0503 .
GeneIDi 2796763.
KEGGi dvu:DVU0503.
PATRICi 32060976. VBIDesVul119526_0480.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.
PhylomeDBi Q72ER6.

Enzyme and pathway databases

BioCyci DVUL882:GJIL-524-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiPNP_DESVH
AccessioniPrimary (citable) accession number: Q72ER6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3