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Q72DM8

- PYRF_DESVH

UniProt

Q72DM8 - PYRF_DESVH

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, DVU_0901
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Substrate By similarity
Binding sitei31 – 311Substrate By similarity
Active sitei60 – 601Proton donor By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei190 – 1901Substrate By similarity
Binding sitei210 – 2101Substrate; via amide nitrogen By similarity
Binding sitei211 – 2111Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciDVUL882:GJIL-925-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:DVU_0901
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_0000241855Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi882.DVU0901.

Structurei

3D structure databases

ProteinModelPortaliQ72DM8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 6710Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.
PhylomeDBiQ72DM8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72DM8-1 [UniParc]FASTAAdd to Basket

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MAELVVALDF PAADVAVDMA GRLRGTAPWM KVGLELFCAA GPDVVRAVAD    50
LGFRVFLDLK FHDIPNTVRG AVRSAVRSGA DMVNIHLMGG ERMARAAVEG 100
LHEGAQTTGS VPLLFGVTVL TSTAQGELPG ISTDIGEYAA SLAASGAAWG 150
LNGVVCSGYE VESIKKRCGA SFLCLTPGIR PGGGAGGDDQ RRVMTPAQAV 200
SAGSDYLVVG RPVTGAADPA AAARAIMAEM AAVRR 235
Length:235
Mass (Da):24,025
Last modified:July 5, 2004 - v1
Checksum:i892DC580E9D51098
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS95381.1.
RefSeqiYP_010122.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS95381; AAS95381; DVU_0901.
GeneIDi2795411.
KEGGidvu:DVU0901.
PATRICi32061716. VBIDesVul119526_0845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS95381.1 .
RefSeqi YP_010122.1. NC_002937.3.

3D structure databases

ProteinModelPortali Q72DM8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU0901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS95381 ; AAS95381 ; DVU_0901 .
GeneIDi 2795411.
KEGGi dvu:DVU0901.
PATRICi 32061716. VBIDesVul119526_0845.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.
PhylomeDBi Q72DM8.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci DVUL882:GJIL-925-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiPYRF_DESVH
AccessioniPrimary (citable) accession number: Q72DM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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