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Q72DJ9 (PROB_DESVH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate 5-kinase

EC=2.7.2.11
Alternative name(s):
Gamma-glutamyl kinase
Short name=GK
Gene names
Name:proB
Ordered Locus Names:DVU_0930
OrganismDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]
Taxonomic identifier882 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity. HAMAP-Rule MF_00456

Catalytic activity

ATP + L-glutamate = ADP + L-glutamate 5-phosphate. HAMAP-Rule MF_00456

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. HAMAP-Rule MF_00456

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00456.

Sequence similarities

Belongs to the glutamate 5-kinase family.

Contains 1 PUA domain.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-proline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from electronic annotation. Source: InterPro

glutamate 5-kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Glutamate 5-kinase HAMAP-Rule MF_00456
PRO_0000109668

Regions

Domain285 – 36379PUA
Nucleotide binding220 – 2267ATP By similarity

Sites

Binding site201ATP By similarity
Binding site591Substrate By similarity
Binding site1461Substrate By similarity
Binding site1581Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72DJ9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 67EA38D2B188D385

FASTA38040,567
        10         20         30         40         50         60 
MEWTEERAAA LREARCVVVK VGSAVLTTET GVNLAVIDSL AAQLSALQES GKRVVLVSSG 

        70         80         90        100        110        120 
AVAAGRSALR DCCEIAGMPH KQAASAVGQS RLMHHYDEAF ARYGHLSAQV LLTRDDLRNR 

       130        140        150        160        170        180 
ERFLNARNTF QALLDWGVIP VVNENDTVAV QELKFGDNDC LASLLLNVVE GDLYVNLTSA 

       190        200        210        220        230        240 
SGVYADNPQT NPEAGILPCI EDVHTLDLDV MCGGKTSVGT GGMYSKLLAA SRAAQLGVPT 

       250        260        270        280        290        300 
LILPGREPRI LERAFSGEPV GTWVRPEARV VSRRKYWLAY QSEPSGTVTV DEGAARALLQ 

       310        320        330        340        350        360 
QGGSLLPGGV CDVSGAFEPG ALVRIAGPDG TVIAVGLSNY GDRDLVRIKG HRRHEVAAIL 

       370        380 
GDAHFPEVVH RDNMLLDAVV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017285 Genomic DNA. Translation: AAS95410.1.
RefSeqYP_010151.1. NC_002937.3.

3D structure databases

ProteinModelPortalQ72DJ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING882.DVU0930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS95410; AAS95410; DVU_0930.
GeneID2794630.
KEGGdvu:DVU0930.
PATRIC32061774. VBIDesVul119526_0874.

Phylogenomic databases

eggNOGCOG0263.
KOK00931.
OMAMRMIAGH.
OrthoDBEOG6PGK7G.
PhylomeDBQ72DJ9.

Enzyme and pathway databases

BioCycDVUL882:GJIL-954-MONOMER.
UniPathwayUPA00098; UER00359.

Family and domain databases

Gene3D2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPMF_00456. ProB.
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFPIRSF000729. GK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SMARTSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsTIGR01027. proB. 1 hit.
PROSITEPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROB_DESVH
AccessionPrimary (citable) accession number: Q72DJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways