Q72DH4 (ALR_DESVH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase
EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	DVU_0955

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio vulgaris

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP-Rule MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Alanine racemase HAMAP-Rule MF_01201		PRO_1000164592
Sites
	Active site	36	1	Proton acceptor; specific for D-alanine By similarity
	Active site	266	1	Proton acceptor; specific for L-alanine By similarity
	Binding site	134	1	Substrate By similarity
	Binding site	314	1	Substrate; via amide nitrogen By similarity
Amino acid modifications
	Modified residue	36	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q72DH4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F41CD32773346D72	FASTA	376	39,406
	10 20 30 40 50 60 MPISYNKASV VVSLQSIIAN YRRIRTVAQR PMPVIKSDAY GHGLEAVGMA LEAEGARECA 70 80 90 100 110 120 VGTVGEGAKL RKAGFGADIV ALLGALDRED AQLAASSGII PTVLDIAGLE RLAAQGTPER 130 140 150 160 170 180 PVRVALKFDT GMARLGFTEH DVSALCERLR TLPSVRPVMA VSHLAVADDP TQSAFTMAQG 190 200 210 220 230 240 AAFARIMAGL RSNFPDIMGS LSNSAATLAH PQLHWDVQRP GIALYGSNPL RGTALARHGE 250 260 270 280 290 300 GLLPAMSVSV PVLQVHPLPA GRSISYGRTY TATKDATVAI IAAGYADNYS RALSGRGVAV 310 320 330 340 350 360 AGGRRVPVLG RVCMQTTAID VTDVPGIATG DRVWLLGGPG PATVSADELA DLWGTISYEV 370 LCLLGMNPRR HDDSVE

References

[1]

"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D.E. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017285 Genomic DNA. Translation: AAS95435.1.
RefSeq	YP_010176.1. NC_002937.3.
3D structure databases
HSSP	HSSP built from PDB template 1XFC based on UniProtKB P0A4X2.
ProteinModelPortal	Q72DH4.
ModBase	Search...
Protein-protein interaction databases
STRING	882.DVU0955.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS95435; AAS95435; DVU_0955.
GeneID	2795151.
KEGG	dvu:DVU0955.
PATRIC	32061824. VBIDesVul119526_0899.
Phylogenomic databases
eggNOG	COG0787.
KO	K01775.
OMA	GQWQDIA.
ProtClustDB	CLSK704957.
Enzyme and pathway databases
BioCyc	DVUL882:GJIL-979-MONOMER.
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_DESVH

Accession

Primary (citable) accession number: Q72DH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program