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Q72DH4 (ALR_DESVH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:DVU_0955
OrganismDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]
Taxonomic identifier882 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Alanine racemase HAMAP-Rule MF_01201
PRO_1000164592

Sites

Active site361Proton acceptor; specific for D-alanine By similarity
Active site2661Proton acceptor; specific for L-alanine By similarity
Binding site1341Substrate By similarity
Binding site3141Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue361N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72DH4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F41CD32773346D72

FASTA37639,406
        10         20         30         40         50         60 
MPISYNKASV VVSLQSIIAN YRRIRTVAQR PMPVIKSDAY GHGLEAVGMA LEAEGARECA 

        70         80         90        100        110        120 
VGTVGEGAKL RKAGFGADIV ALLGALDRED AQLAASSGII PTVLDIAGLE RLAAQGTPER 

       130        140        150        160        170        180 
PVRVALKFDT GMARLGFTEH DVSALCERLR TLPSVRPVMA VSHLAVADDP TQSAFTMAQG 

       190        200        210        220        230        240 
AAFARIMAGL RSNFPDIMGS LSNSAATLAH PQLHWDVQRP GIALYGSNPL RGTALARHGE 

       250        260        270        280        290        300 
GLLPAMSVSV PVLQVHPLPA GRSISYGRTY TATKDATVAI IAAGYADNYS RALSGRGVAV 

       310        320        330        340        350        360 
AGGRRVPVLG RVCMQTTAID VTDVPGIATG DRVWLLGGPG PATVSADELA DLWGTISYEV 

       370 
LCLLGMNPRR HDDSVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017285 Genomic DNA. Translation: AAS95435.1.
RefSeqYP_010176.1. NC_002937.3.

3D structure databases

ProteinModelPortalQ72DH4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING882.DVU0955.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS95435; AAS95435; DVU_0955.
GeneID2795151.
KEGGdvu:DVU0955.
PATRIC32061824. VBIDesVul119526_0899.

Phylogenomic databases

eggNOGCOG0787.
KOK01775.
OMAISHFACA.
OrthoDBEOG6PP9NJ.
PhylomeDBQ72DH4.

Enzyme and pathway databases

BioCycDVUL882:GJIL-979-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_DESVH
AccessionPrimary (citable) accession number: Q72DH4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways