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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei584ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL882:G1GT1-1226-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DVU_1196
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002194 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520111 – 829Leucine--tRNA ligaseAdd BLAST829

Proteomic databases

PaxDbiQ72CT7
PRIDEiQ72CT7

Interactioni

Protein-protein interaction databases

IntActiQ72CT7, 2 interactors
STRINGi882.DVU1196

Structurei

3D structure databases

ProteinModelPortaliQ72CT7
SMRiQ72CT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 50"HIGH" regionAdd BLAST11
Motifi581 – 585"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ
PhylomeDBiQ72CT7

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q72CT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDHQSIET RWQKKWEDSG IFQCDTEADK PKYYVLEMFP YPSGNIHMGH
60 70 80 90 100
VRNYSIGDVV ARFKRMQGFN VLHPMGWDAF GLPAENAAIK NGTHPAKWTF
110 120 130 140 150
ANIDNMRSQL KRLGYSYDWQ REVATCTPEY YRWEQLFFLR FLEKGLVYRK
160 170 180 190 200
KAAQNWCPKC HTVLANEQVI EGLCWRCDSA VEQKELTQWF LRITDYAEEL
210 220 230 240 250
LADLSKLENG WPERVLSMQR NWIGKSTGAE IRFALDGRDD SITVFTTRPD
260 270 280 290 300
TIFGATFMSI APEHPLVEEL IDGKPQADDV RAFVERIRNM DRIDRQSDTL
310 320 330 340 350
EKEGVFTGAY CVNPFTGRKM PIWVANFVLA EYGTGAVMAV PAHDQRDFEF
360 370 380 390 400
ARKYDLPMQV VIQPQGEALD PATMSAAWTE AGALVNSGAF DGLANEDAKQ
410 420 430 440 450
RIADDLETTG NGRRTINYRL RDWNISRQRY WGAPIPVIYC DACGVVPEKE
460 470 480 490 500
ENLPVVLPLD VKTHDDGRSP LPHTPAFYEC TCPVCGGKAR RETDTMDTFV
510 520 530 540 550
ESSWYFARYT DATNDKAPFT PDALRYWLPV DQYIGGVEHA ILHLLYSRFF
560 570 580 590 600
TKALRDCGFI ELDEPFANLL TQGMVLMDGS KMSKSKGNVV DPTEMIARYG
610 620 630 640 650
ADTVRLFCLF AAPPERDFDW SESGIEGSYR FVGRVWRLVE ELREHLLAVG
660 670 680 690 700
ACSSTAEDAK TPVARELRLK EHATVRKAGD DLNDRFQFNT AIAAVMELVN
710 720 730 740 750
ALYLAKDELV ADESGRKVLS SAVSTVLTLL SPFTPHLSEE LWALLGHTES
760 770 780 790 800
VSTLPWPRWK EDALVRDTVT LVVQVNGKLR GKLDIPADAS REEVETLALN
810 820
EPNVLRYLEG VTVRKVVVIP GKLVNVVVS
Length:829
Mass (Da):93,980
Last modified:July 5, 2004 - v1
Checksum:i075C5C6BED149142
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA Translation: AAS95674.1
RefSeqiWP_010938492.1, NC_002937.3
YP_010415.1, NC_002937.3

Genome annotation databases

EnsemblBacteriaiAAS95674; AAS95674; DVU_1196
GeneIDi2796653
KEGGidvu:DVU1196
PATRICifig|882.5.peg.1120

Similar proteinsi

Entry informationi

Entry nameiSYL_DESVH
AccessioniPrimary (citable) accession number: Q72CT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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