Q72CN5 (SYR_DESVH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	DVU_1248

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio vulgaris

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00123
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: UniProtKB-HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_0000242016
Regions
	Motif	125 – 135	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q72CN5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1F2085596C6C67C5	FASTA	551	60,510
	10 20 30 40 50 60 MRAKKQLLAA LQDIVKDMGL AWPEKATIDT PKATGFGDLA ANIALVLAKQ AGQNPRELAT 70 80 90 100 110 120 RIADALRNRD ADITAIDIAG PGFLNVTYSQ DFWRETILRA QEAGSAFGSS DTGAGRKVQV 130 140 150 160 170 180 EYVSANPTGP LHIGHGRGAA VGDSLARIMR FAGYDVSTEY YINDAGRQMR LLGLSVWVRA 190 200 210 220 230 240 KELAGRPVTL PEDFYRGDYI KDIARELMEK EPGLLDLDDA AGEDRCFAYA MSSILDGIKQ 250 260 270 280 290 300 DLADFRVEHQ VWFSERSLVE GGAVEKTFNR LKEAGLAFEQ DGALWFRTTD FGDDKDRVLR 310 320 330 340 350 360 KSDGTLTYFS SDIAYHDNKY DRGFDLVVDI WGADHHGYIP RMRAAVAALG RKPEAFDVVL 370 380 390 400 410 420 IQLVNLLRGG ELVAMSTRAG QFETLADVVK ETGADAARFM FLSRKSDSPL DFDLELVKQR 430 440 450 460 470 480 TMDNPVYYVQ YAHARVCSVL RKAAERGIEM PAQLDGASLA PLSGDDEMEL LRLLDRFEET 490 500 510 520 530 540 VAGAATALAP HHISHYLMEV AGALHSYYAR QPILNATEQD VIVPRLALLR AVGCVLANGL 550 SLLGVSAPES M

References

[1]

"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D.E. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017285 Genomic DNA. Translation: AAS95726.1.
RefSeq	YP_010467.1. NC_002937.3.
3D structure databases
ProteinModelPortal	Q72CN5.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	882.DVU1248.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS95726; AAS95726; DVU_1248.
GeneID	2795029.
KEGG	dvu:DVU1248.
PATRIC	32062366. VBIDesVul119526_1167.
Phylogenomic databases
eggNOG	COG0018.
KO	K01887.
OMA	NPNGPLH.
OrthoDB	EOG6JB13C.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	DVUL882:GJIL-1274-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF47323. SSF47323. 1 hit. SSF55190. SSF55190. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_DESVH

Accession

Primary (citable) accession number: Q72CN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	July 5, 2004
Last modified:	February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program