Q72CC2 (Q72CC2_DESVH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid A disaccharide synthase EMBL AAS95839.1
EC=2.4.1.182 EMBL AAS95839.1

Gene names

Name:	lpxB EMBL AAS95839.1
Ordered Locus Names:	DVU_1361

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL AAS95839.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q72CC2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9C7F60BD44F7E5DC	FASTA	376	41,536
	10 20 30 40 50 60 MPPSIWINTG ELSGDMHGAA LLEALRALAP DLSCTGMGGP YLRAAGQQAM LRVEDLSVMG 70 80 90 100 110 120 ITEVIAYLPR IFSMLRDIRA ELARTRPDAV VLIDAPEFNF RVAKAATDLG IPVYYYISPK 130 140 150 160 170 180 IWAWRTGRVQ FIKRHVRRML SILPFEVDFY RRHGMEVDYV GNPLVDMVDW PALAAIAPVA 190 200 210 220 230 240 GRIGLMPGSR RKEVESLMPA FGDAARLMLE HRPGLEFHCM RAPSTTEAAL RALWPQDIPL 250 260 270 280 290 300 HIVAPEDRYH AVRSCQMLIA ASGTATLETA LIGTPTLVTY KVSPFSYWLG RKLVKVRFAA 310 320 330 340 350 360 LPNLVLDREV FPELLQEKAT GPVIAQHAAA WLDAPEALAA VRSELDVLRT MLGEPGAAGR 370 AARIIIDDLT GRKQQD

References

[1]

"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N., Methe B., Brinkac L.M., Daugherty S.C., Deboy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed: 15077118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017285 Genomic DNA. Translation: AAS95839.1.
RefSeq	YP_010580.1. NC_002937.3.
3D structure databases
ProteinModelPortal	Q72CC2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72CC2.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2795085.
GenomeReviews	Gene locus DVU_1361 in contig AE017285_GR.
KEGG	dvu:DVU1361.
NMPDR	fig|882.1.peg.1355.
PATRIC	32062580. VBIDesVul119526_1272.
TIGR	DVU_1361.
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	AEFAFIC.
PhylomeDB	Q72CC2.
ProtClustDB	CLSK705191.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q72CC2_DESVH

Accession

Primary (citable) accession number: Q72CC2

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)