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Q72C59

- GCSPA_DESVH

UniProt

Q72C59 - GCSPA_DESVH

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciDVUL882:GJIL-1454-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:DVU_1425
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045646Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi882.DVU1425.

Structurei

3D structure databases

ProteinModelPortaliQ72C59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.
PhylomeDBiQ72C59.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72C59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFVPHSPED VSVMLDAIGV NTIEDLFADI PAEMRPKSFA LPKGLSEMDV
60 70 80 90 100
CSRLEALSAR NRTDVVSFLG AGFYDHHIPK AVDALSSRGE FYTAYTPYQP
110 120 130 140 150
EAAQGTLQAI FEFQTAVCRL LDMDCANASV YDGGSALFEA MMMAVRATRR
160 170 180 190 200
RKLVIDEALS PIYRTMLASY TSNLQLELVT VPHRDGLSDM DALKASVDDT
210 220 230 240 250
CAAVVVQNPN FFGAITDFTD LFTHARAHKA LGVISVYPVM QSVLKTPGEM
260 270 280 290 300
GADIAVADGQ SIGQPLSFGG PYLGIMTCTK PLVRQIPGRI VGRTQDVDGR
310 320 330 340 350
TGYVLTLQAR EQHIRRAKAT SNICSNQALC ALRSLIHLTL LGPEGLVRTA
360 370 380 390 400
ELSMERARYA AERLTALPGV ELLHDAPFGN EFAVRLPVSA FEVVDRLTAR
410 420 430 440
GYVPGFPVGR YYPGMDNVLL VACTEKHSFE QVGILAEMLG GIL
Length:443
Mass (Da):48,152
Last modified:July 5, 2004 - v1
Checksum:iA709219D63099AE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS95903.1.
RefSeqiYP_010644.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS95903; AAS95903; DVU_1425.
GeneIDi2794686.
KEGGidvu:DVU1425.
PATRICi32062688. VBIDesVul119526_1327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS95903.1 .
RefSeqi YP_010644.1. NC_002937.3.

3D structure databases

ProteinModelPortali Q72C59.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU1425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS95903 ; AAS95903 ; DVU_1425 .
GeneIDi 2794686.
KEGGi dvu:DVU1425.
PATRICi 32062688. VBIDesVul119526_1327.

Phylogenomic databases

eggNOGi COG0403.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.
PhylomeDBi Q72C59.

Enzyme and pathway databases

BioCyci DVUL882:GJIL-1454-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiGCSPA_DESVH
AccessioniPrimary (citable) accession number: Q72C59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3