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Protein

Hypoxanthine phosphoribosyltransferase

Gene

hpt

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine phosphoribosyltransferase (hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPurine salvageUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

BioCyciDVUL882:G1GT1-1631-MONOMER
UniPathwayiUPA00591; UER00648

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Gene namesi
Name:hptImported
Ordered Locus Names:DVU_1588Imported
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)Imported
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002194 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ72BP6

Interactioni

Protein-protein interaction databases

IntActiQ72BP6, 1 interactor
STRINGi882.DVU1588

Structurei

3D structure databases

ProteinModelPortaliQ72BP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 159PribosyltranInterPro annotationAdd BLAST149

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGV Bacteria
COG0634 LUCA
KOiK00760
OMAiTMDWMAV
OrthoDBiPOG091H02F3
PhylomeDBiQ72BP6

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR005904 Hxn_phspho_trans
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01203 HGPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q72BP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIKDLKVVY SEEQIAARVR ELAQEINRLY KGEPLVVVCV LKGAFMFFTD
60 70 80 90 100
LVRHLDMHPE LDFVRLASYG DATHRGSTIS FLKDVEVKLE GKHVLIVEDI
110 120 130 140 150
VDTGHTMDFL FRQLAARGAK SMRLAVLVDK TERREVPVRA DFVGFALPRG
160 170
FIVGYGLDYA QKYRELGAIY EAIVDA
Length:176
Mass (Da):19,962
Last modified:July 5, 2004 - v1
Checksum:i532C13645884807A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA Translation: AAS96066.1
RefSeqiWP_010938879.1, NC_002937.3
YP_010807.1, NC_002937.3

Genome annotation databases

EnsemblBacteriaiAAS96066; AAS96066; DVU_1588
GeneIDi2796024
KEGGidvu:DVU1588
PATRICifig|882.5.peg.1464

Similar proteinsi

Entry informationi

Entry nameiQ72BP6_DESVH
AccessioniPrimary (citable) accession number: Q72BP6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health