Q72AU2 (SYGA_DESVH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine--tRNA ligase alpha subunit
EC=6.1.1.14

Alternative name(s):
Glycyl-tRNA synthetase alpha subunit
Short name=GlyRS

Gene names

Name:	glyQ
Ordered Locus Names:	DVU_1898

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP MF_00254
Subunit structure	Tetramer of two alpha and two beta subunits By similarity.
Subcellular location	Cytoplasm HAMAP MF_00254.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Glycine--tRNA ligase alpha subunit HAMAP MF_00254		PRO_1000047416

Sequences

	Sequence		Length	Mass (Da)
	Q72AU2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 499DA7F4AFF0D20D	FASTA	289	33,236
	10 20 30 40 50 60 MHFQNVILTL QNYWASRGCV ITQPIDVECG AGTFNPSTFL RVIGPEPWNV AYVEPSRRPT 70 80 90 100 110 120 DGRYGENPNR LQHYFQFQVI LKPSPDNVQE LYLGSLRALG IDPAAHDIRF VEDDWESPTL 130 140 150 160 170 180 GAWGLGWEVW LNGMEVTQFT YFQQVGGIDL APTSVEITYG LERLCMYLQG KESVYDLDWN 190 200 210 220 230 240 EHVTYGDIYH QNEVEQSKYN FERSDAAMLL HAFNAYETEC RRLTEEGLLW PAYDYCLKCS 250 260 270 280 HTFNLLDARG AISITERTGY IGRVRYLASG VARLYAAQRE QLGYPMLRK

References

[1]

"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D.E. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed: 15077118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017285 Genomic DNA. Translation: AAS96374.1.
RefSeq	YP_011115.1. NC_002937.3.
3D structure databases
HSSP	HSSP built from PDB template 1J5W based on UniProtKB Q9WY59.
ProteinModelPortal	Q72AU2.
SMR	Q72AU2. Positions 1-275.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72AU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2794709.
GenomeReviews	Gene locus DVU_1898 in contig AE017285_GR.
KEGG	dvu:DVU1898.
PATRIC	32063536. VBIDesVul119526_1741.
TIGR	DVU_1898.
Phylogenomic databases
eggNOG	COG0752.
HOGENOM	HBG285316.
OMA	CRRPTDG.
PhylomeDB	Q72AU2.
ProtClustDB	PRK09348.
Enzyme and pathway databases
BioCyc	DVUL882:DVU_1898-MONOMER.
Family and domain databases
HAMAP	MF_00254. Gly_tRNA_synth_alpha. [Tree]
InterPro	IPR006194. Gly-tRNA-synth_II_heterodimer. IPR002310. Gly-tRNA_synth_IIc_asu. [Graphical view]
KO	K01878.
Pfam	PF02091. tRNA-synt_2e. 1 hit. [Graphical view]
PRINTS	PR01044. TRNASYNTHGA.
TIGRFAMs	TIGR00388. GlyQ. 1 hit.
PROSITE	PS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYGA_DESVH

Accession

Primary (citable) accession number: Q72AU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program