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Q729U1 (RUVC_DESVH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:DVU_2258
OrganismDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]
Taxonomic identifier882 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 166166Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_0000225140

Sites

Metal binding111Magnesium By similarity
Metal binding701Magnesium By similarity
Metal binding1421Magnesium By similarity
Metal binding1451Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q729U1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5012E7E3C5FEAD66

FASTA16617,245
        10         20         30         40         50         60 
MAASVTVIGI DPGSQCTGWG IVREASGVLT LVDCGAIRPK GGDFAARLGD LYRQLADVVR 

        70         80         90        100        110        120 
AHTPDEAAVE DVHAAQNVAT ALKLGQARGV VVAACAAHGV PVIDYRPSVI KKALVGTGRA 

       130        140        150        160 
EKEQVGYMVG QVLGVRPDWK LDTGDALAAA ICHLNQRRLT RLAGLA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017285 Genomic DNA. Translation: AAS96731.1.
RefSeqYP_011471.1. NC_002937.3.

3D structure databases

ProteinModelPortalQ729U1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING882.DVU2258.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS96731; AAS96731; DVU_2258.
GeneID2794080.
KEGGdvu:DVU2258.
PATRIC32064170. VBIDesVul119526_2051.

Phylogenomic databases

eggNOGCOG0817.
KOK01159.
OMAILHMIKL.
OrthoDBEOG6RG044.
ProtClustDBPRK00039.

Enzyme and pathway databases

BioCycDVUL882:GJIL-2311-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVC_DESVH
AccessionPrimary (citable) accession number: Q729U1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families