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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206FADUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciDVUL882:GJIL-2404-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:DVU_2350
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002194 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000346336Add
BLAST

Proteomic databases

PaxDbiQ729K0.

Interactioni

Protein-protein interaction databases

STRINGi882.DVU2350.

Structurei

3D structure databases

ProteinModelPortaliQ729K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
KOiK04094.
OMAiDYLNCPM.
OrthoDBiPOG091H00B3.
PhylomeDBiQ729K0.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q729K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSLTTITT AAIIGAGLAG CECALRLARA GVRVTLFEMK PAAFSPAHSN
60 70 80 90 100
PDLGELVCSN SLRSDDIASG VGLLKQEMRE LGSIVMEAAD ATRVPAGKAL
110 120 130 140 150
AVDRDLFARH ITAVIEAEPG ITLERREVAS LDDPALASAD VVVIAAGPLA
160 170 180 190 200
SAGLSDSLAA VVGGQLYFYD AIAPIIAAES IDLSIVFSGS RYGEPGEEGD
210 220 230 240 250
YLNCPMNRDE YDAFYEALLA AEKVPSRDFE KELHFEGCMP IEALAERGPR
260 270 280 290 300
TLVFGPFKPV GFTDPRTGTR PYAIIQLRAE NRNKTAFNIV GCQTKLKYAE
310 320 330 340 350
QERVFRMIPG LAGAEFVRHG SVHRNTYVNA PRVLADDLSL RADKRVFLAG
360 370 380 390 400
QITGVEGYVE SAACGMWLGM VLAARIQGRE LPTPPPQTAL GALLMHLRTP
410 420 430 440 450
VKNFQPSNAN FGLMPELGLK VKKRERKPLY SARAREHFVR WLAEAGVTPV
460 470
IEPLLPTAPD TTGAAGEETT QAES
Length:474
Mass (Da):50,947
Last modified:July 5, 2004 - v1
Checksum:i13B7710BC3B6F66A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA. Translation: AAS96823.1.
RefSeqiWP_010939623.1. NC_002937.3.
YP_011563.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS96823; AAS96823; DVU_2350.
GeneIDi2795524.
KEGGidvu:DVU2350.
PATRICi32064324. VBIDesVul119526_2127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA. Translation: AAS96823.1.
RefSeqiWP_010939623.1. NC_002937.3.
YP_011563.1. NC_002937.3.

3D structure databases

ProteinModelPortaliQ729K0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi882.DVU2350.

Proteomic databases

PaxDbiQ729K0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS96823; AAS96823; DVU_2350.
GeneIDi2795524.
KEGGidvu:DVU2350.
PATRICi32064324. VBIDesVul119526_2127.

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
KOiK04094.
OMAiDYLNCPM.
OrthoDBiPOG091H00B3.
PhylomeDBiQ729K0.

Enzyme and pathway databases

BioCyciDVUL882:GJIL-2404-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRMFO_DESVH
AccessioniPrimary (citable) accession number: Q729K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.