panC

Functionⁱ

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityⁱ

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayⁱ

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Sites

Feature key	Position(s)	Length	Description
Active siteⁱ	37 – 37	1	Proton donorUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158
Binding siteⁱ	61 – 61	1	Beta-alanineUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158
Binding siteⁱ	61 – 61	1	PantoateUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158
Binding siteⁱ	153 – 153	1	PantoateUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158
Binding siteⁱ	176 – 176	1	ATP; via amide nitrogen and carbonyl oxygenUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158

Regions

Feature key	Position(s)	Length	Description
Nucleotide bindingⁱ	30 – 37	8	ATPUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158
Nucleotide bindingⁱ	147 – 150	4	ATPUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158
Nucleotide bindingⁱ	184 – 187	4	ATPUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158

Enzyme and pathway databases

BioCycⁱ	DVUL882:GJIL-2504-MONOMER.
UniPathwayⁱ	UPA00028; UER00005.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pantothenate synthetaseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158 (EC:6.3.2.1UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158 ) Short name: PSUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158 Alternative name(s): Pantoate--beta-alanine ligaseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158 Pantoate-activating enzymeUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158
Gene namesⁱ	Name:panCUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00158 Ordered Locus Names:DVU_2448
Organismⁱ	Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifierⁱ	882 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio vulgaris
Proteomesⁱ	UP000002194: Chromosome

Subcellular locationⁱ

Cytoplasm UniRule annotation

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 283	283	Pantothenate synthetase		PRO_0000128226	Add BLAST

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	882.DVU2448.

STRINGⁱ

882.DVU2448.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q729A4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	COG0414.
KOⁱ	K01918.
OMAⁱ	ALHKGHQ.
OrthoDBⁱ	EOG6Z6FZ4.
PhylomeDBⁱ	Q729A4.

Family and domain databases

Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00158. PanC.
InterProⁱ	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHERⁱ	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfamⁱ	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMsⁱ	TIGR00018. panC. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q729A4-1 [UniParc]FASTA Add to Basket

« Hide

        10         20         30         40         50
MQIITEPQTI QQACLRWRAD GVHTALVPTM GYYHAGHESL MAHARAVSEK 
        60         70         80         90        100
VIVSLFVNPA QFGPGEDFAA YPRDLERDAA MAEAQGVDVL FAPKAEDLYK 
       110        120        130        140        150
KDHATWVEVP ALSQTMCGLS RPTHFRGVCT VVTKLLMLTM PRIAVFGQKD 
       160        170        180        190        200
WQQVAVIRRM VRDLNIPVDI VGRPIVREPD GLAMSSRNIY LTAEERLQAP 
       210        220        230        240        250
HIHHGLALGR AITQSGERDA ETIKTAIRRY WAQNLPGGEE DYLTIVDPVS 
       260        270        280 
LEPVDRLTGA TLCATAVRVG QARLLDNMML LGD

Length:283

Mass (Da):31,345

Last modified:July 5, 2004 - v1

Checksum:ⁱA438BB7446D3BEFB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017285 Genomic DNA. Translation: AAS96920.1.
RefSeqⁱ	YP_011660.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaⁱ	AAS96920; AAS96920; DVU_2448.
GeneIDⁱ	2796625.
KEGGⁱ	dvu:DVU2448.
PATRICⁱ	32064508. VBIDesVul119526_2217.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017285 Genomic DNA. Translation: AAS96920.1.
RefSeqⁱ	YP_011660.1. NC_002937.3.

3D structure databases

ProteinModelPortalⁱ	Q729A4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	882.DVU2448.

STRINGⁱ

882.DVU2448.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAS96920; AAS96920; DVU_2448.
GeneIDⁱ	2796625.
KEGGⁱ	dvu:DVU2448.
PATRICⁱ	32064508. VBIDesVul119526_2217.

Phylogenomic databases

eggNOGⁱ	COG0414.
KOⁱ	K01918.
OMAⁱ	ALHKGHQ.
OrthoDBⁱ	EOG6Z6FZ4.
PhylomeDBⁱ	Q729A4.

Enzyme and pathway databases

UniPathwayⁱ	UPA00028; UER00005.
BioCycⁱ	DVUL882:GJIL-2504-MONOMER.

Family and domain databases

Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00158. PanC.
InterProⁱ	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHERⁱ	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfamⁱ	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMsⁱ	TIGR00018. panC. 1 hit.
ProtoNetⁱ	Search...

Publicationsⁱ

Entry informationⁱ

Entry nameⁱ

PANC_DESVH

Accessionⁱ

Primary (citable) accession number: Q729A4

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	July 5, 2004
Last modified:	January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

External Data

Dasty 3

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

Proteomes

UniRef

Supporting data

UniParc

Help

Q729A4 - PANC_DESVH

UniProt

Q729A4 - PANC_DESVH

Your basket is currently empty.

Pantothenate synthetase

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>Describes the metabolic pathway(s) associated with a protein.</p><p><a href='../manual/pathway' target='_top'>More...</a></p>Pathwayi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>Contains the literature citations that are the sources of data used to annotate the entry. Each reference is numbered and contains several subsections allowing a precise description of a given citation.</p><p><a href='../manual/publications_section' target='_top'>More...</a></p>Publicationsi

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Miscellaneous

Documents

External Data

Functionⁱ

Pathwayⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Publicationsⁱ

Entry informationⁱ

Miscellaneousⁱ