panC

Functionⁱ

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityⁱ

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayⁱ: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

Pantothenate synthetase (panC)

This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	37	Proton donorUniRule annotation	1
Binding siteⁱ	61	Beta-alanineUniRule annotation	1
Binding siteⁱ	61	PantoateUniRule annotation	1
Binding siteⁱ	153	PantoateUniRule annotation	1
Binding siteⁱ	176	ATP; via amide nitrogen and carbonyl oxygenUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	30 – 37	ATPUniRule annotation	8
Nucleotide bindingⁱ	147 – 150	ATPUniRule annotation	4
Nucleotide bindingⁱ	184 – 187	ATPUniRule annotation	4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
pantoate-beta-alanine ligase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

pantothenate biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Biological process	Pantothenate biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	DVUL882:G1GT1-2512-MONOMER.
UniPathwayⁱ	UPA00028; UER00005.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation) Short name: PSUniRule annotation Alternative name(s): Pantoate--beta-alanine ligaseUniRule annotation Pantoate-activating enzymeUniRule annotation
Gene namesⁱ	Name:panCUniRule annotation Ordered Locus Names:DVU_2448
Organismⁱ	Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Taxonomic identifierⁱ	882 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio vulgaris
Proteomesⁱ	UP000002194 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00158

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000128226	1 – 283	Pantothenate synthetaseAdd BLAST		283

Proteomic databases

PaxDbⁱ	Q729A4.

PaxDbⁱ

Q729A4.

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	882.DVU2448.

STRINGⁱ

882.DVU2448.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q729A4.
SMRⁱ	Q729A4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108IAA. Bacteria. COG0414. LUCA.
KEGG Orthology (KO) More...KOⁱ	K01918.
OMAⁱ	LFNMVQP.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00FM.
PhylomeDBⁱ	Q729A4.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00560. PanC. 1 hit.
Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00158. PanC. 1 hit.
InterProⁱ	View protein in InterPro IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold.
PANTHERⁱ	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsⁱ	TIGR00018. panC. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q729A4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQIITEPQTI QQACLRWRAD GVHTALVPTM GYYHAGHESL MAHARAVSEK 
        60         70         80         90        100
VIVSLFVNPA QFGPGEDFAA YPRDLERDAA MAEAQGVDVL FAPKAEDLYK 
       110        120        130        140        150
KDHATWVEVP ALSQTMCGLS RPTHFRGVCT VVTKLLMLTM PRIAVFGQKD 
       160        170        180        190        200
WQQVAVIRRM VRDLNIPVDI VGRPIVREPD GLAMSSRNIY LTAEERLQAP 
       210        220        230        240        250
HIHHGLALGR AITQSGERDA ETIKTAIRRY WAQNLPGGEE DYLTIVDPVS 
       260        270        280 
LEPVDRLTGA TLCATAVRVG QARLLDNMML LGD

Length:283

Mass (Da):31,345

Last modified:July 5, 2004 - v1

Checksum:ⁱA438BB7446D3BEFB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017285 Genomic DNA. Translation: AAS96920.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010939719.1. NC_002937.3. YP_011660.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaⁱ	AAS96920; AAS96920; DVU_2448.
GeneIDⁱ	2796625.
KEGGⁱ	dvu:DVU2448.
PATRICⁱ	fig\|882.5.peg.2217.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q729A4	A1VBJ2 A0A0E0T4D8	Desulfovibrio vulgaris subsp. vulgaris (strain DP4) Desulfovibrio vulgaris (strain RCH1)	283	UniRef100_Q729A4	Cluster: Pantothenate synthetase	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q729A4	A1VBJ2 A0A0E0T4D8	Desulfovibrio vulgaris subsp. vulgaris (strain DP4) Desulfovibrio vulgaris (strain RCH1)	283	UniRef90_Q729A4	Cluster: Pantothenate synthetase	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q729A4	A1VBJ2 A0A0E0T4D8 E1JT06 UPI00041DAF4A F0JKG3 A0A1J5N5T5 C6C1U6 A0A1J1DPG0 A0A1M7TF20 A0A1K1LGC4 +17	Desulfovibrio vulgaris subsp. vulgaris (strain DP4) Desulfovibrio vulgaris (strain RCH1) Desulfovibrio fructosivorans JJ Desulfovibrio bastinii Desulfovibrio desulfuricans ND132 Desulfovibrio dechloracetivorans Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763) Candidatus Desulfovibrio trichonymphae Desulfovibrio litoralis DSM 11393 Desulfovibrio piger And more	283	UniRef50_Q729A4	Cluster: Pantothenate synthetase	28

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017285 Genomic DNA. Translation: AAS96920.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010939719.1. NC_002937.3. YP_011660.1. NC_002937.3.

3D structure databases

ProteinModelPortalⁱ	Q729A4.
SMRⁱ	Q729A4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	882.DVU2448.

STRINGⁱ

882.DVU2448.

Proteomic databases

PaxDbⁱ	Q729A4.

PaxDbⁱ

Q729A4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAS96920; AAS96920; DVU_2448.
GeneIDⁱ	2796625.
KEGGⁱ	dvu:DVU2448.
PATRICⁱ	fig\|882.5.peg.2217.

Phylogenomic databases

eggNOGⁱ	ENOG4108IAA. Bacteria. COG0414. LUCA.
KEGG Orthology (KO) More...KOⁱ	K01918.
OMAⁱ	LFNMVQP.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00FM.
PhylomeDBⁱ	Q729A4.

Enzyme and pathway databases

UniPathwayⁱ	UPA00028; UER00005.
BioCycⁱ	DVUL882:G1GT1-2512-MONOMER.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00560. PanC. 1 hit.
Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00158. PanC. 1 hit.
InterProⁱ	View protein in InterPro IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold.
PANTHERⁱ	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsⁱ	TIGR00018. panC. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PANC_DESVH
Accessionⁱ	Q729A4Primary (citable) accession number: Q729A4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
	Last sequence update:	July 5, 2004
	Last modified:	February 28, 2018
	This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q729A4 (PANC_DESVH)

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Pantothenate synthetase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-pantothenate biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: (R)-pantothenate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ