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Q729A4

- PANC_DESVH

UniProt

Q729A4 - PANC_DESVH

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Protein

Pantothenate synthetase

Gene
panC, DVU_2448
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donor By similarity
Binding sitei61 – 611Beta-alanine By similarity
Binding sitei61 – 611Pantoate By similarity
Binding sitei153 – 1531Pantoate By similarity
Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATP By similarity
Nucleotide bindingi147 – 1504ATP By similarity
Nucleotide bindingi184 – 1874ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL882:GJIL-2504-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:DVU_2448
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pantothenate synthetaseUniRule annotationPRO_0000128226Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi882.DVU2448.

Structurei

3D structure databases

ProteinModelPortaliQ729A4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
KOiK01918.
OMAiIVRDSDH.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ729A4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q729A4-1 [UniParc]FASTAAdd to Basket

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MQIITEPQTI QQACLRWRAD GVHTALVPTM GYYHAGHESL MAHARAVSEK    50
VIVSLFVNPA QFGPGEDFAA YPRDLERDAA MAEAQGVDVL FAPKAEDLYK 100
KDHATWVEVP ALSQTMCGLS RPTHFRGVCT VVTKLLMLTM PRIAVFGQKD 150
WQQVAVIRRM VRDLNIPVDI VGRPIVREPD GLAMSSRNIY LTAEERLQAP 200
HIHHGLALGR AITQSGERDA ETIKTAIRRY WAQNLPGGEE DYLTIVDPVS 250
LEPVDRLTGA TLCATAVRVG QARLLDNMML LGD 283
Length:283
Mass (Da):31,345
Last modified:July 5, 2004 - v1
Checksum:iA438BB7446D3BEFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS96920.1.
RefSeqiYP_011660.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS96920; AAS96920; DVU_2448.
GeneIDi2796625.
KEGGidvu:DVU2448.
PATRICi32064508. VBIDesVul119526_2217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS96920.1 .
RefSeqi YP_011660.1. NC_002937.3.

3D structure databases

ProteinModelPortali Q729A4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU2448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS96920 ; AAS96920 ; DVU_2448 .
GeneIDi 2796625.
KEGGi dvu:DVU2448.
PATRICi 32064508. VBIDesVul119526_2217.

Phylogenomic databases

eggNOGi COG0414.
KOi K01918.
OMAi IVRDSDH.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q729A4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci DVUL882:GJIL-2504-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiPANC_DESVH
AccessioniPrimary (citable) accession number: Q729A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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