UniProtKB - Q729A4 (PANC_DESVH)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Pantothenate synthetase
Gene
panC
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Functioni
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
Miscellaneous
The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation
Catalytic activityi
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
: (R)-pantothenate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Pantothenate synthetase (panC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 37 | Proton donorUniRule annotation | 1 | |
Binding sitei | 61 | Beta-alanineUniRule annotation | 1 | |
Binding sitei | 61 | PantoateUniRule annotation | 1 | |
Binding sitei | 153 | PantoateUniRule annotation | 1 | |
Binding sitei | 176 | ATP; via amide nitrogen and carbonyl oxygenUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 30 – 37 | ATPUniRule annotation | 8 | |
Nucleotide bindingi | 147 – 150 | ATPUniRule annotation | 4 | |
Nucleotide bindingi | 184 – 187 | ATPUniRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- pantoate-beta-alanine ligase activity Source: UniProtKB-EC
GO - Biological processi
- pantothenate biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Ligase |
Biological process | Pantothenate biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | DVUL882:G1GT1-2512-MONOMER. |
UniPathwayi | UPA00028; UER00005. |
Names & Taxonomyi
Protein namesi | Recommended name: Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)Short name: PSUniRule annotation Alternative name(s): Pantoate--beta-alanine ligaseUniRule annotation Pantoate-activating enzymeUniRule annotation |
Gene namesi | Name:panCUniRule annotation Ordered Locus Names:DVU_2448 |
Organismi | Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303) |
Taxonomic identifieri | 882 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000128226 | 1 – 283 | Pantothenate synthetaseAdd BLAST | 283 |
Proteomic databases
PaxDbi | Q729A4. |
Interactioni
Subunit structurei
Homodimer.UniRule annotation
Protein-protein interaction databases
STRINGi | 882.DVU2448. |
Structurei
3D structure databases
ProteinModelPortali | Q729A4. |
SMRi | Q729A4. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the pantothenate synthetase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108IAA. Bacteria. COG0414. LUCA. |
KOi | K01918. |
OMAi | LFNMVQP. |
OrthoDBi | POG091H00FM. |
PhylomeDBi | Q729A4. |
Family and domain databases
CDDi | cd00560. PanC. 1 hit. |
Gene3Di | 3.40.50.620. 1 hit. |
HAMAPi | MF_00158. PanC. 1 hit. |
InterProi | View protein in InterPro IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. |
PANTHERi | PTHR21299:SF1. PTHR21299:SF1. 1 hit. |
Pfami | View protein in Pfam PF02569. Pantoate_ligase. 1 hit. |
TIGRFAMsi | TIGR00018. panC. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q729A4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQIITEPQTI QQACLRWRAD GVHTALVPTM GYYHAGHESL MAHARAVSEK
60 70 80 90 100
VIVSLFVNPA QFGPGEDFAA YPRDLERDAA MAEAQGVDVL FAPKAEDLYK
110 120 130 140 150
KDHATWVEVP ALSQTMCGLS RPTHFRGVCT VVTKLLMLTM PRIAVFGQKD
160 170 180 190 200
WQQVAVIRRM VRDLNIPVDI VGRPIVREPD GLAMSSRNIY LTAEERLQAP
210 220 230 240 250
HIHHGLALGR AITQSGERDA ETIKTAIRRY WAQNLPGGEE DYLTIVDPVS
260 270 280
LEPVDRLTGA TLCATAVRVG QARLLDNMML LGD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017285 Genomic DNA. Translation: AAS96920.1. |
RefSeqi | WP_010939719.1. NC_002937.3. YP_011660.1. NC_002937.3. |
Genome annotation databases
EnsemblBacteriai | AAS96920; AAS96920; DVU_2448. |
GeneIDi | 2796625. |
KEGGi | dvu:DVU2448. |
PATRICi | fig|882.5.peg.2217. |
Similar proteinsi
Entry informationi
Entry namei | PANC_DESVH | |
Accessioni | Q729A4Primary (citable) accession number: Q729A4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 28, 2018 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |