Q728N8 (Q728N8_DESVH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dethiobiotin synthetase EMBL AAS97037.1
EC=6.3.3.3 EMBL AAS97037.1

Gene names

Name:	bioD EMBL AAS97037.1
Ordered Locus Names:	DVU_2565

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring By similarity. SAAS SAAS004472
Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. SAAS SAAS004472
Cofactor	Magnesium By similarity. SAAS SAAS004472
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. SAAS SAAS004472
Subcellular location	Cytoplasm By similarity SAAS SAAS004472.

Ontologies

Keywords
Biological process	Biotin biosynthesis SAAS SAAS004472
Cellular component	Cytoplasm SAAS SAAS004472
Ligand	ATP-binding SAAS SAAS004472 Magnesium SAAS SAAS004472 Metal-binding SAAS SAAS004472 Nucleotide-binding
Molecular function	Ligase SAAS SAAS004472 EMBL AAS97037.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dethiobiotin synthase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q728N8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4B0277351D4853A8	FASTA	246	26,169
	10 20 30 40 50 60 MSAHEMNHAT PRLPAPLFVT GTDTGVGKTV VSLLLMRALF RRGMVPFYAK PMQTGCRDPY 70 80 90 100 110 120 DTDSDAAFVY RHVPELAERD PAEAVGWCFR APKAPLHAAR DERNGVETED LMRRLAILRA 130 140 150 160 170 180 THACLVLEGA GGLMVPFTAD ALCVDCIRAA DARPVLVARD GLGTVNHTLL SVEAMTRRGV 190 200 210 220 230 240 TPAGIVFVAS GKRPTPSDLV HDNMEAVAML SGISVSGIVP PILDFHAPPE AALTVADAVI DAALGL

References

[1]

"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N., Methe B., Brinkac L.M., Daugherty S.C., Deboy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed: 15077118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017285 Genomic DNA. Translation: AAS97037.1.
RefSeq	YP_011777.1. NC_002937.3.
3D structure databases
ProteinModelPortal	Q728N8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q728N8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2796258.
GenomeReviews	Gene locus DVU_2565 in contig AE017285_GR.
KEGG	dvu:DVU2565.
NMPDR	fig|882.1.peg.2552.
PATRIC	32064736. VBIDesVul119526_2324.
TIGR	DVU_2565.
Phylogenomic databases
eggNOG	COG0132.
HOGENOM	HBG650065.
OMA	AEAVGWC.
PhylomeDB	Q728N8.
ProtClustDB	CLSK705871.
Family and domain databases
HAMAP	MF_00336. BioD. [Tree]
InterPro	IPR002586. CbiA_P_synth. IPR004472. DTB_synth_BioD. [Graphical view]
KO	K01935.
Pfam	PF01656. CbiA. 1 hit. [Graphical view]
PIRSF	PIRSF006755. DTB_synth. 1 hit.
TIGRFAMs	TIGR00347. BioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q728N8_DESVH

Accession

Primary (citable) accession number: Q728N8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)