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Q727G3

- GCH4_DESVH

UniProt

Q727G3 - GCH4_DESVH

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei145 – 1451May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:DVU_2892
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264GTP cyclohydrolase FolE2PRO_0000147709Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi882.DVU2892.

Structurei

3D structure databases

ProteinModelPortaliQ727G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
OMAiDVQSSRD.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q727G3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDVQNSPAQ VAMPIDRVGV KNLQLPLVVS DRAQGRQHTV ATVDIGVDLP
60 70 80 90 100
AHFKGTHMSR FVEALENWTE ELDYASMKRL LEDVKTRLEA RKAYVLFRFP
110 120 130 140 150
YFIRKKAPAT GSPGLVCYQC RLTGELEEGR PSFLLEVEVP VMTVCPCSKA
160 170 180 190 200
ISDEGAHSQR AVVRIAVRMT RFSWLEEFID LAEVSGSSPV YTLLKREDEK
210 220 230 240 250
YVTEDAFAHP TFVEDVVRAA AQRLERHPQI SWFRVEVESF ESIHCHNAFA
260
SIERTITPET QPGS
Length:264
Mass (Da):29,880
Last modified:July 5, 2004 - v1
Checksum:i4859520E9CA5E10C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS97364.1.

Genome annotation databases

EnsemblBacteriaiAAS97364; AAS97364; DVU_2892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS97364.1 .

3D structure databases

ProteinModelPortali Q727G3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU2892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS97364 ; AAS97364 ; DVU_2892 .

Phylogenomic databases

eggNOGi COG1469.
OMAi DVQSSRD.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiGCH4_DESVH
AccessioniPrimary (citable) accession number: Q727G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3