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Q727G3 (GCH4_DESVH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:DVU_2892
OrganismDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]
Taxonomic identifier882 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147709

Sites

Site1451May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q727G3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4859520E9CA5E10C

FASTA26429,880
        10         20         30         40         50         60 
MEDVQNSPAQ VAMPIDRVGV KNLQLPLVVS DRAQGRQHTV ATVDIGVDLP AHFKGTHMSR 

        70         80         90        100        110        120 
FVEALENWTE ELDYASMKRL LEDVKTRLEA RKAYVLFRFP YFIRKKAPAT GSPGLVCYQC 

       130        140        150        160        170        180 
RLTGELEEGR PSFLLEVEVP VMTVCPCSKA ISDEGAHSQR AVVRIAVRMT RFSWLEEFID 

       190        200        210        220        230        240 
LAEVSGSSPV YTLLKREDEK YVTEDAFAHP TFVEDVVRAA AQRLERHPQI SWFRVEVESF 

       250        260 
ESIHCHNAFA SIERTITPET QPGS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017285 Genomic DNA. Translation: AAS97364.1.

3D structure databases

ProteinModelPortalQ727G3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING882.DVU2892.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS97364; AAS97364; DVU_2892.

Phylogenomic databases

eggNOGCOG1469.
OMAINMYVDL.
ProtClustDBPRK13674.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_DESVH
AccessionPrimary (citable) accession number: Q727G3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways