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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciDVUL882:G1GT1-3113-MONOMER
UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:DVU_3029
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002194 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055471 – 704Phosphate acetyltransferaseAdd BLAST704

Proteomic databases

PaxDbiQ726S7
PRIDEiQ726S7

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

IntActiQ726S7, 3 interactors
STRINGi882.DVU3029

Structurei

3D structure databases

ProteinModelPortaliQ726S7
SMRiQ726S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni380 – 704Phosphate acetyltransferaseAdd BLAST325

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4105C6K Bacteria
COG0280 LUCA
COG0857 LUCA
KOiK13788
OMAiTPLMFEY
OrthoDBiPOG091H01MW
PhylomeDBiQ726S7

Family and domain databases

Gene3Di3.40.1390.20, 1 hit
InterProiView protein in InterPro
IPR010766 DRTGG
IPR016475 P-Actrans_bac
IPR027417 P-loop_NTPase
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
IPR028979 Ser_kin/Pase_Hpr-like_N_sf
PfamiView protein in Pfam
PF07085 DRTGG, 1 hit
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF006107 PhpActrans_proteobac, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75138 SSF75138, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q726S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNLYITAT ESKSGKSAVV LGMMQLLLRD VRKVAFFRPI INQASTDVRD
60 70 80 90 100
HDINLILRHF GLDIAYEDTY AYSLQDAREL INNGQHATLL DNILKKYKKL
110 120 130 140 150
EDAYDFVLCE GTDFLGKDAA FEFELNADIA ANLGCPVMVV ANGQQKAARE
160 170 180 190 200
LIASTQLTID LLDEKGLDVV TAVINRATVT EAEREEIIKS LECKVNCSNP
210 220 230 240 250
LAVYVLPEES TLGKPTMNDV KKWLGAQVLY GHGRLDTLVD DYIIAAMQIG
260 270 280 290 300
NFLDYVSQGC LVITPGDRSD IILSSLASRL STAYPDISGL LLTGGLEPAA
310 320 330 340 350
NVHRLIEGWT GVPIPILSVK DHTYKTIQTL NELYGKIEPD NDRKINTALA
360 370 380 390 400
LFERHIDSSE LGSRLINRKS SRITPKMFEF NLIEKAKRNR MRIVLPEGAE
410 420 430 440 450
ERILRAADIL VRREVADIIL LGDANTVGSR IGDLGLDMDG VQIVQPNLSP
460 470 480 490 500
KFDEYVAAYH ECRKKKGISM EQARDMMNDP TYFGTMMVHK GDADGMVSGA
510 520 530 540 550
INTTAHTIRP AFEFIKTKPG VSIVSSVFLM CLKDRVLVFG DCAVNPNPTA
560 570 580 590 600
EQLAEIAISA SHTARIFGVD PRVAMLSYST GSSGKGADVE KVIEATRIAK
610 620 630 640 650
ERAPELLLEG PLQYDAAIDM DVARTKLPGS TVAGQATVFI FPDLNTGNNT
660 670 680 690 700
YKAVQRAAGA VAIGPVLQGL NKPVNDLSRG CTVADIVNTV AITAIQAQAE

KGLI
Length:704
Mass (Da):76,830
Last modified:July 5, 2004 - v1
Checksum:iC0459B13A61D8DAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA Translation: AAS97500.1
RefSeqiWP_010940288.1, NC_002937.3
YP_012240.1, NC_002937.3

Genome annotation databases

EnsemblBacteriaiAAS97500; AAS97500; DVU_3029
GeneIDi2796446
KEGGidvu:DVU3029
PATRICifig|882.5.peg.2747

Similar proteinsi

Entry informationi

Entry nameiPTA_DESVH
AccessioniPrimary (citable) accession number: Q726S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health