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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:DVU_3029
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002194 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055471 – 704Phosphate acetyltransferaseAdd BLAST704

Proteomic databases

PaxDbiQ726S7.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

IntActiQ726S7. 3 interactors.
STRINGi882.DVU3029.

Structurei

3D structure databases

ProteinModelPortaliQ726S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni380 – 704Phosphate acetyltransferaseAdd BLAST325

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4105C6K. Bacteria.
COG0280. LUCA.
COG0857. LUCA.
KOiK13788.
OMAiVTPLMFE.
OrthoDBiPOG091H01MW.
PhylomeDBiQ726S7.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N-like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q726S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNLYITAT ESKSGKSAVV LGMMQLLLRD VRKVAFFRPI INQASTDVRD
60 70 80 90 100
HDINLILRHF GLDIAYEDTY AYSLQDAREL INNGQHATLL DNILKKYKKL
110 120 130 140 150
EDAYDFVLCE GTDFLGKDAA FEFELNADIA ANLGCPVMVV ANGQQKAARE
160 170 180 190 200
LIASTQLTID LLDEKGLDVV TAVINRATVT EAEREEIIKS LECKVNCSNP
210 220 230 240 250
LAVYVLPEES TLGKPTMNDV KKWLGAQVLY GHGRLDTLVD DYIIAAMQIG
260 270 280 290 300
NFLDYVSQGC LVITPGDRSD IILSSLASRL STAYPDISGL LLTGGLEPAA
310 320 330 340 350
NVHRLIEGWT GVPIPILSVK DHTYKTIQTL NELYGKIEPD NDRKINTALA
360 370 380 390 400
LFERHIDSSE LGSRLINRKS SRITPKMFEF NLIEKAKRNR MRIVLPEGAE
410 420 430 440 450
ERILRAADIL VRREVADIIL LGDANTVGSR IGDLGLDMDG VQIVQPNLSP
460 470 480 490 500
KFDEYVAAYH ECRKKKGISM EQARDMMNDP TYFGTMMVHK GDADGMVSGA
510 520 530 540 550
INTTAHTIRP AFEFIKTKPG VSIVSSVFLM CLKDRVLVFG DCAVNPNPTA
560 570 580 590 600
EQLAEIAISA SHTARIFGVD PRVAMLSYST GSSGKGADVE KVIEATRIAK
610 620 630 640 650
ERAPELLLEG PLQYDAAIDM DVARTKLPGS TVAGQATVFI FPDLNTGNNT
660 670 680 690 700
YKAVQRAAGA VAIGPVLQGL NKPVNDLSRG CTVADIVNTV AITAIQAQAE

KGLI
Length:704
Mass (Da):76,830
Last modified:July 5, 2004 - v1
Checksum:iC0459B13A61D8DAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA. Translation: AAS97500.1.
RefSeqiWP_010940288.1. NC_002937.3.
YP_012240.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS97500; AAS97500; DVU_3029.
GeneIDi2796446.
KEGGidvu:DVU3029.
PATRICi32065612. VBIDesVul119526_2747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA. Translation: AAS97500.1.
RefSeqiWP_010940288.1. NC_002937.3.
YP_012240.1. NC_002937.3.

3D structure databases

ProteinModelPortaliQ726S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ726S7. 3 interactors.
STRINGi882.DVU3029.

Proteomic databases

PaxDbiQ726S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS97500; AAS97500; DVU_3029.
GeneIDi2796446.
KEGGidvu:DVU3029.
PATRICi32065612. VBIDesVul119526_2747.

Phylogenomic databases

eggNOGiENOG4105C6K. Bacteria.
COG0280. LUCA.
COG0857. LUCA.
KOiK13788.
OMAiVTPLMFE.
OrthoDBiPOG091H01MW.
PhylomeDBiQ726S7.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N-like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTA_DESVH
AccessioniPrimary (citable) accession number: Q726S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.