ID   Q726F3_DESVH            Unreviewed;       963 AA.
AC   Q726F3;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 133.
DE   SubName: Full=Methyl-accepting chemotaxis protein DcrH {ECO:0000313|EMBL:AAS97625.1};
GN   Name=dcrH {ECO:0000313|EMBL:AAS97625.1};
GN   OrderedLocusNames=DVU_3155 {ECO:0000313|EMBL:AAS97625.1};
OS   Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS   B-1760 / Hildenborough).
OC   Bacteria; Thermodesulfobacteriota; Desulfovibrionia; Desulfovibrionales;
OC   Desulfovibrionaceae; Nitratidesulfovibrio.
OX   NCBI_TaxID=882 {ECO:0000313|EMBL:AAS97625.1, ECO:0000313|Proteomes:UP000002194};
RN   [1] {ECO:0000313|EMBL:AAS97625.1, ECO:0000313|Proteomes:UP000002194}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough
RC   {ECO:0000313|Proteomes:UP000002194};
RX   PubMed=15077118; DOI=10.1038/nbt959;
RA   Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA   Kolonay J.F., Eisen J.A., Ward N., Methe B., Brinkac L.M., Daugherty S.C.,
RA   Deboy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C.,
RA   Sullivan S.A., Fouts D., Haft D.H., Selengut J., Peterson J.D.,
RA   Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M.,
RA   Tran K., Khouri H., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D.,
RA   Voordouw G., Fraser C.M.;
RT   "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT   Desulfovibrio vulgaris Hildenborough.";
RL   Nat. Biotechnol. 22:554-559(2004).
RN   [2] {ECO:0007829|PDB:3AGT, ECO:0007829|PDB:3AGU}
RP   X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 828-963, AND X-RAY
RP   CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 828-963.
RA   Onoda A., Okamoto Y., Sugimoto H., Mizohata E., Inoue T., Shiro Y.,
RA   Hayashi T.;
RT   "Characteristics of Diiron Site with Large Cavity in Hemerythrin-like
RT   Domain of DcrH.";
RL   Submitted (APR-2010) to the PDB data bank.
RN   [3] {ECO:0007829|PDB:3WAQ}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 828-963 IN COMPLEX WITH IRON
RP   OXIDE (2FE-O).
RX   PubMed=24187962; DOI=10.1021/ic401632x;
RA   Okamoto Y., Onoda A., Sugimoto H., Takano Y., Hirota S., Kurtz D.M.,
RA   Shiro Y., Hayashi T.;
RT   "Crystal structure, exogenous ligand binding, and redox properties of an
RT   engineered diiron active site in a bacterial hemerythrin.";
RL   Inorg. Chem. 52:13014-13020(2013).
RN   [4] {ECO:0007829|PDB:3WHN}
RP   X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 828-963 IN COMPLEX WITH CA(2+).
RX   PubMed=24400317; DOI=10.1039/c3cc48108e;
RA   Okamoto Y., Onoda A., Sugimoto H., Takano Y., Hirota S., Kurtz D.M.,
RA   Shiro Y., Hayashi T.;
RT   "H2O2-dependent substrate oxidation by an engineered diiron site in a
RT   bacterial hemerythrin.";
RL   Chem. Commun. (Camb.) 50:3421-3423(2014).
CC   -!- SIMILARITY: Belongs to the hemerythrin family.
CC       {ECO:0000256|ARBA:ARBA00010587}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AE017285; AAS97625.1; -; Genomic_DNA.
DR   RefSeq; WP_010940413.1; NC_002937.3.
DR   RefSeq; YP_012365.1; NC_002937.3.
DR   PDB; 3AGT; X-ray; 1.40 A; A/B=828-963.
DR   PDB; 3AGU; X-ray; 1.80 A; A/B=828-963.
DR   PDB; 3WAQ; X-ray; 1.80 A; A=828-963.
DR   PDB; 3WHN; X-ray; 1.90 A; A/B=828-963.
DR   PDBsum; 3AGT; -.
DR   PDBsum; 3AGU; -.
DR   PDBsum; 3WAQ; -.
DR   PDBsum; 3WHN; -.
DR   AlphaFoldDB; Q726F3; -.
DR   SMR; Q726F3; -.
DR   STRING; 882.DVU_3155; -.
DR   PaxDb; 882-DVU_3155; -.
DR   EnsemblBacteria; AAS97625; AAS97625; DVU_3155.
DR   KEGG; dvu:DVU_3155; -.
DR   PATRIC; fig|882.5.peg.2860; -.
DR   eggNOG; COG0840; Bacteria.
DR   eggNOG; COG2703; Bacteria.
DR   HOGENOM; CLU_000445_107_10_7; -.
DR   OrthoDB; 9816383at2; -.
DR   PhylomeDB; Q726F3; -.
DR   EvolutionaryTrace; Q726F3; -.
DR   Proteomes; UP000002194; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd12107; Hemerythrin; 1.
DR   CDD; cd11386; MCP_signal; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.20.120.50; Hemerythrin-like; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR016131; Haemerythrin_Fe_BS.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR012312; Hemerythrin-like.
DR   InterPro; IPR035938; Hemerythrin-like_sf.
DR   InterPro; IPR012827; Hemerythrin_metal-bd.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   NCBIfam; NF033749; bact_hemeryth; 1.
DR   NCBIfam; TIGR02481; hemeryth_dom; 1.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF01814; Hemerythrin; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF47188; Hemerythrin-like; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS00550; HEMERYTHRINS; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3AGT, ECO:0007829|PDB:3AGU};
KW   Calcium {ECO:0007829|PDB:3WHN}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0007829|PDB:3WHN};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002194};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        422..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          445..497
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          544..780
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   REGION          596..616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         927
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:3WHN"
SQ   SEQUENCE   963 AA;  104483 MW;  06AF4DF66DAE491E CRC64;
     MTLKRKLMVG FILALFVTCT LIAGVNWYFA HDGMNGIGDT AVEAMKDRAR GQLESIRSAK
     ALHIEDLFQR IRNQTRTLAE SLTVREAATT LSAAYFTVQG ETTGALDAKA LRGKLTEDYA
     GANYLANPTF ATHARTAKGY APRPAETYLP KDANGIILQA MYVHPSGNPN PLGEKHRLDA
     NPLASTYNTL HRKYHPILRN YLTTFGYYDI FIIDAASGVI VYTVFKEKDY ATSLLTGPYR
     DTGLGAVFRE AVENGRKGRR DAVSISDFAP YEPSYNAPAA FIAAPVFDDR GTCQAVLAFQ
     MPVDNIDRIM TSNGRWQEVG LGTTGETYLV GPDMHPRSKL RAASGASDEV VVDSEAARKA
     LGGESGTATI RDYRGKNVLA AWQPLRLEGL HYGLIAEIDI DEALLAASKI TAARQGAEAR
     TLWGTLLVLA LGTLLGSGIA IALVGALSRP LQRLQVYAGD VAAGNLDARP EGQYPAELDA
     MRHSIESMVQ NLRMRIHEAD AKGMEAADSA QAAQAALDKA RASETRIKGL MERMTGAAGK
     ARSVSEHVSR SINDLTAQVH TITQGVETQR HRMDDTAQAM DTMRTMVSDV ADNARRAAEQ
     ADLSRGHAQQ GASGVGEAVA SIGQVRERIE RLNTAMARLG EEADSIGKVM SVISDIADQT
     NLLALNAAIE AARAGDAGRG FAVVADEVRK LAEKTMQATG EVGSAVTRIQ THTRDNIAAV
     ETAMREATAS ADAATASGRV MDDIVSRVDE TAGMVQSIAA ASDQQAAAAT MVGRNVEEVN
     AIAGDTAASM SHFAGTLEDI FSQVQELFSM IEVISTGEEG VSVLADTGDA DVLVKWSEDL
     ANLPSIDTQH KRLVDYINDL YRAARRRDMD KAREVFDALK NYAVEHFGYE ERLFADYAYP
     EATRHKEIHR RFVETVLKWE KQLAAGDPEV VMTTLRGLVD WLVNHIMKED KKYEAYLRER
     GVS
//