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Q725Q3 (METE_DESVH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:DVU_3371
OrganismDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifier882 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7857855-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_0000098629

Sites

Metal binding6701Zinc By similarity
Metal binding6721Zinc By similarity
Metal binding7551Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q725Q3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B458F003C50FCF4B

FASTA78585,446
        10         20         30         40         50         60 
MRTHNLGFPR IGAGRELKKA VEGYWKGRVS RHALEGEAAR LRACHWAMQR DAGIDVVPVG 

        70         80         90        100        110        120 
DFALYDHMLD LTLMLGAIPP RFSPSGAAAS PAGTGQDIDL MFRMARGEAG LSPVAPLEMT 

       130        140        150        160        170        180 
KWFDTNYHYL VPELDADTAF APDASPLVAQ LREAQDAGFT PKAVLPGPLT WLWLARSVDG 

       190        200        210        220        230        240 
SDRFALLPAL CDAYATLLRE LTSACPPACP RGYSSGGLMV QLDEPVLALD LPQTVRDLFP 

       250        260        270        280        290        300 
AVYTRLRAAV PDATLMVASY FAPCADNLPV ALNLPVDVLH LDLVRGRDDL DAALQVLGAG 

       310        320        330        340        350        360 
EGTPGLALSL GVVDGRNVWC ADIDAAVNLV RRAADSLGED RVWVAPSCSL LHCPVDLGSE 

       370        380        390        400        410        420 
RELDPEVARW LAFARQKCAE VRLVAEVVRG VYGPSTAASL EANREVRRQR AVSPRIHDPA 

       430        440        450        460        470        480 
VASRLAAVTS DMEHRTSPYA ERIVAQRAAL HLPTLPTTTI GSFPQTPDIR AARRALRDGS 

       490        500        510        520        530        540 
LTQDAYEAAM RDALAMMVRE QEALGLDVLV HGEPERNDMV EYFGGLLQGF CITSDGWVQS 

       550        560        570        580        590        600 
YGTRCVKPPL LYGDVSRPEP MTVAWSAYAR SLTARPMKAM LTGPVTIACW SFVRDDISRE 

       610        620        630        640        650        660 
TVLRQLALAL RDEVADLESA GLAVVQVDEP ALREGLPLRR AAQEAYLDAA VRAFRLATSG 

       670        680        690        700        710        720 
VADATQLHTH MCYCDFHDII DRIAGMDADV ISLEASRSRM ELLDVFATHG YPNEVGPGVY 

       730        740        750        760        770        780 
DIHSPRVPSV DEMEALLLRA AAVLPVDRLW VNPDCGLKTR EWPETRAALA NMVEAARRVR 


ARLDA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017285 Genomic DNA. Translation: AAS97840.1.
RefSeqYP_012580.1. NC_002937.3.

3D structure databases

ProteinModelPortalQ725Q3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ725Q3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2795685.
GenomeReviewsGene locus DVU_3371 in contig AE017285_GR.
KEGGdvu:DVU3371.
NMPDRfig|882.1.peg.3355.
PATRIC32066259. VBIDesVul119526_3060.
TIGRDVU_3371.

Phylogenomic databases

eggNOGCOG0620.
HOGENOMHBG287495.
OMARNIWRAN.
PhylomeDBQ725Q3.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycDVUL882:DVU_3371-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_DESVH
AccessionPrimary (citable) accession number: Q725Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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