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Q725I1

- GSA_DESVH

UniProt

Q725I1 - GSA_DESVH

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDVUL882:GJIL-3251-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:DVU_3168
    OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
    Taxonomic identifieri882 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002194: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000243570Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei266 – 2661N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ725I1.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi882.DVU3168.

    Structurei

    3D structure databases

    ProteinModelPortaliQ725I1.
    SMRiQ725I1. Positions 2-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.
    PhylomeDBiQ725I1.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q725I1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQRSSELFE RAQQLIPGGV NSPVRACLGV DSEPLFIARA AGSRLHTVDG    50
    ETFIDFVESW GPMLLGHTHP EVTAAVHAAV DRGTSYGAPC EDEVVLAAKV 100
    VDALPGVDMV RMVNSGTEAT MSALRLARGY TGRTKLVKFV GCYHGHADPF 150
    LASAGSGVAT LSIPGTPGVP ESTVRDTLLA PYNDLAAVKD LFALHGKDIA 200
    AIIVEAVAGN MGLVPPKAGF LEGLRELCDQ HGALLIFDEV ITGFRVSFGG 250
    AQQRFGITPD LTTLGKIIGG GLPVGAYGGK REIMQRIAPC GEVYQAGTLS 300
    GNPLAMAAGI ATLDVLSRSD YAGLEARVAA FVKELEAILK GKGVPVRINT 350
    LASMFTVFFT NDPVTDFASA KTADGALYTS FYKQMRAQGI YLAPSPFEAA 400
    MVSFAHTDDD LAAMLDAARK VTF 423
    Length:423
    Mass (Da):44,469
    Last modified:July 5, 2004 - v1
    Checksum:i3587A9C3DB05C3F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017285 Genomic DNA. Translation: AAS97638.1.
    RefSeqiWP_010940426.1. NC_002937.3.
    YP_012378.1. NC_002937.3.

    Genome annotation databases

    EnsemblBacteriaiAAS97638; AAS97638; DVU_3168.
    GeneIDi2795873.
    KEGGidvu:DVU3168.
    PATRICi32065878. VBIDesVul119526_2873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017285 Genomic DNA. Translation: AAS97638.1 .
    RefSeqi WP_010940426.1. NC_002937.3.
    YP_012378.1. NC_002937.3.

    3D structure databases

    ProteinModelPortali Q725I1.
    SMRi Q725I1. Positions 2-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 882.DVU3168.

    Proteomic databases

    PRIDEi Q725I1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS97638 ; AAS97638 ; DVU_3168 .
    GeneIDi 2795873.
    KEGGi dvu:DVU3168.
    PATRICi 32065878. VBIDesVul119526_2873.

    Phylogenomic databases

    eggNOGi COG0001.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.
    PhylomeDBi Q725I1.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci DVUL882:GJIL-3251-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

    Entry informationi

    Entry nameiGSA_DESVH
    AccessioniPrimary (citable) accession number: Q725I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3