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Protein
Submitted name:

Reverse transcriptase/RNaseH

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi443ManganeseCombined sources1
Metal bindingi478ManganeseCombined sources1
Metal bindingi498ManganeseCombined sources1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed DNA polymeraseSAAS annotationImported, Transferase

Keywords - Ligandi

ManganeseCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Reverse transcriptase/RNaseHImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL247.
DrugBankiDB01048. Abacavir.
DB00705. Delavirdine.
DB00900. Didanosine.
DB00625. Efavirenz.
DB00879. Emtricitabine.
DB00709. Lamivudine.
DB00238. Nevirapine.
DB08864. Rilpivirine.
DB00649. Stavudine.
DB00300. Tenofovir.
DB00943. Zalcitabine.
DB00495. Zidovudine.

Interactioni

Protein-protein interaction databases

IntActiQ72547. 1 interactor.
MINTiMINT-8208544.

Chemistry databases

BindingDBiQ72547.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JLEX-ray2.90A/B1-566[»]
3HYFX-ray1.70A427-506[»]
A517-561[»]
3QINX-ray1.70A427-506[»]
A517-561[»]
3QIOX-ray1.40A427-506[»]
A517-561[»]
ProteinModelPortaliQ72547.
SMRiQ72547.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72547.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 234Reverse transcriptaseInterPro annotationAdd BLAST191
Domaini434 – 557RNase HInterPro annotationAdd BLAST124

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q72547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PISPIETVPV KLKPGMDGPK VKQWPLTEEK IKALVEICTE MEKEGKISKI
60 70 80 90 100
GPENPYNTPV FAIKKKDSTK WRKLVDFREL NKRTQDFWEV QLGIPHPAGL
110 120 130 140 150
KKRKSVTVLD VGDAYFSVPL DEDFRKYTAF TIPSINNETP GIRYQYNVLP
160 170 180 190 200
QGWKGSPAIF QSSMTKILEP FRKQNPDIVI YQYMDDLYVG SDLEIGQHRT
210 220 230 240 250
KIEELRQHLL RWGLTTPDKK HQKEPPFLWM GYELHPDKWT VQPIVLPEKD
260 270 280 290 300
SWTVNDIQKL VGKLNWASQI YPGIRVRQLC KLLRGTKALT EVIPLTEEAE
310 320 330 340 350
LELAENREIL KEPVHGVYYD PSKDLIAEIQ KQGQGQWTYQ IYQEPFKNLR
360 370 380 390 400
TGKYARMRGA HTNDVKQLTE AVQKITTESI VIWGKTPKFK LPIQKETWET
410 420 430 440 450
WWTEYWQATW IPEWEFVNTP PLVKLWYQLE KEPIVGAETF YVDGAANRET
460 470 480 490 500
KLGKAGYVTN RGRQKVVTLT DTTNQKTELQ AIYLALQDSG LEVNIVTDSQ
510 520 530 540 550
YALGIIQAQP DQSESELVNQ IIEQLIKKEK VYLAWVPAHK GIGGNEQVDK
560
LVSAGIRKVL FLDGID
Length:566
Mass (Da):65,224
Last modified:November 1, 1996 - v1
Checksum:iAA4B9287ECC4E5C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei566Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28646 Genomic DNA. Translation: AAA93161.1.
PIRiA47330.
B47330.
C47330.
D47330.
E47330.
F47330.
S32132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28646 Genomic DNA. Translation: AAA93161.1.
PIRiA47330.
B47330.
C47330.
D47330.
E47330.
F47330.
S32132.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JLEX-ray2.90A/B1-566[»]
3HYFX-ray1.70A427-506[»]
A517-561[»]
3QINX-ray1.70A427-506[»]
A517-561[»]
3QIOX-ray1.40A427-506[»]
A517-561[»]
ProteinModelPortaliQ72547.
SMRiQ72547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ72547. 1 interactor.
MINTiMINT-8208544.

Chemistry databases

BindingDBiQ72547.
ChEMBLiCHEMBL247.
DrugBankiDB01048. Abacavir.
DB00705. Delavirdine.
DB00900. Didanosine.
DB00625. Efavirenz.
DB00879. Emtricitabine.
DB00709. Lamivudine.
DB00238. Nevirapine.
DB08864. Rilpivirine.
DB00649. Stavudine.
DB00300. Tenofovir.
DB00943. Zalcitabine.
DB00495. Zidovudine.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ72547.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ72547_9HIV1
AccessioniPrimary (citable) accession number: Q72547
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.