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Protein

Ribose-phosphate pyrophosphokinase 1

Gene

prs1

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ribose 1,5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose-5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP.UniRule annotation

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-phosphate pyrophosphokinase 2 (prs2), Ribose-phosphate pyrophosphokinase 1 (prs1)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Ribose-5-phosphateUniRule annotation
Metal bindingi134 – 1341MagnesiumUniRule annotation
Metal bindingi136 – 1361MagnesiumUniRule annotation
Binding sitei136 – 1361ATPUniRule annotation
Binding sitei141 – 1411ATPUniRule annotation
Metal bindingi145 – 1451MagnesiumUniRule annotation
Metal bindingi149 – 1491MagnesiumUniRule annotation
Binding sitei176 – 1761Ribose-5-phosphateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 453ATPUniRule annotation
Nucleotide bindingi102 – 1054ATPUniRule annotation
Nucleotide bindingi149 – 1502ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00087; UER00172.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinase 1UniRule annotation (EC:2.7.6.1UniRule annotation)
Short name:
RPPK 1UniRule annotation
Alternative name(s):
5-phospho-D-ribosyl alpha-1-diphosphate 1UniRule annotation
Phosphoribosyl diphosphate synthase 1UniRule annotation
Phosphoribosyl pyrophosphate synthase 1UniRule annotation
Short name:
P-Rib-PP synthase 1UniRule annotation
Short name:
PRPP synthase 1UniRule annotation
Short name:
PRPPase 1UniRule annotation
Gene namesi
Name:prs1UniRule annotation
Ordered Locus Names:LMOf2365_0210
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Ribose-phosphate pyrophosphokinase 1PRO_0000141155Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ724L4.
SMRiQ724L4. Positions 2-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2013Ribose-5-phosphate bindingUniRule annotation
Regioni226 – 2338Ribose-5-phosphate bindingUniRule annotation
Regioni312 – 3143Ribose-5-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose-phosphate pyrophosphokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000210449.
KOiK00948.
OMAiDGEIMVE.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B. 1 hit.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q724L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEYFDPKL KIFSLNSNRE LAEEIAKEVG IELGKSSVTH FSDGEIQINI
60 70 80 90 100
EESIRGCHVY VIQSTSNPVN QNLMELLIMI DALKRASAAT INIVMPYYGY
110 120 130 140 150
ARQDRKARSR EPITAKLVAN LIETAGATRM ITLDMHAPQI QGFFDIPIDH
160 170 180 190 200
LNAVRLLSDY FSERHLGDDL VVVSPDHGGV TRARKMADRL KAPIAIIDKR
210 220 230 240 250
RPRPNVAEVM NIVGNVEGKV CIIIDDIIDT AGTITLAAKA LREAGATKVY
260 270 280 290 300
ACCSHPVLSG PAMKRIEESP IEKLVVTNSI ALPEEKWIDK MEQLSVAALL
310
GEAIVRVHEN ASVSSLFE
Length:318
Mass (Da):35,069
Last modified:July 5, 2004 - v1
Checksum:iAB286F742362FECD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT02997.1.
RefSeqiWP_003722728.1. NC_002973.6.

Genome annotation databases

EnsemblBacteriaiAAT02997; AAT02997; LMOf2365_0210.
KEGGilmf:LMOf2365_0210.
PATRICi20321599. VBILisMon105049_0213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT02997.1.
RefSeqiWP_003722728.1. NC_002973.6.

3D structure databases

ProteinModelPortaliQ724L4.
SMRiQ724L4. Positions 2-317.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT02997; AAT02997; LMOf2365_0210.
KEGGilmf:LMOf2365_0210.
PATRICi20321599. VBILisMon105049_0213.

Phylogenomic databases

HOGENOMiHOG000210449.
KOiK00948.
OMAiDGEIMVE.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00172.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B. 1 hit.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKPRS1_LISMF
AccessioniPrimary (citable) accession number: Q724L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.