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Protein
Submitted name:

POL polyprotein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.SAAS annotation
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl proteaseUniRule annotationSAAS annotation, DNA-bindingSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase
Biological processDNA integration, DNA recombinationSAAS annotation, Viral genome integrationSAAS annotation, Virus entry into host cell
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
POL polyproteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000160754 Componenti: Genome

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AO1X-ray1.90A/B765-927[»]
3AO3X-ray1.90A/B765-927[»]
3AO4X-ray1.95A/B765-927[»]
3AO5X-ray1.80A/B765-927[»]
3L3UX-ray1.40A/B765-927[»]
3L3VX-ray2.00A/B765-927[»]
3OVNX-ray1.95A/B765-927[»]
3VQ4X-ray1.90A/B770-927[»]
3VQ5X-ray1.70A/B771-927[»]
3VQ6X-ray1.80A/B770-927[»]
3VQ7X-ray1.63A/B770-927[»]
3VQ8X-ray1.60A/B771-927[»]
3VQ9X-ray1.90A/B/C765-925[»]
3VQAX-ray1.90A/B770-927[»]
3VQBX-ray2.10A/B770-927[»]
3VQCX-ray2.30A/B770-927[»]
3VQDX-ray2.00A/B770-927[»]
3VQEX-ray1.70A/B771-927[»]
3VQPX-ray2.10A/B770-927[»]
3VQQX-ray2.00A/B770-927[»]
5HOTX-ray4.40A/B717-1003[»]
ProteinModelPortaliQ72498.
SMRiQ72498.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72498.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 145Peptidase A2InterPro annotationAdd BLAST70
Domaini199 – 389Reverse transcriptaseInterPro annotationAdd BLAST191
Domaini589 – 712RNase HInterPro annotationAdd BLAST124
Domaini718 – 759Integrase-typeInterPro annotationAdd BLAST42
Domaini769 – 919Integrase catalyticInterPro annotationAdd BLAST151
Domaini938 – 985Integrase-type DNA-bindingInterPro annotationAdd BLAST48

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

CDDicd05482. HIV_retropepsin_like. 1 hit.
Gene3Di1.10.10.200. 1 hit.
2.30.30.10. 1 hit.
2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProiView protein in InterPro
IPR001969. Aspartic_peptidase_AS.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR017856. Integrase_Zn-bd_dom-like_N.
IPR003308. Integrase_Zn-bd_dom_N.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR034170. Retropepsin-like_cat_dom.
IPR018061. Retropepsins.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
PfamiView protein in Pfam
PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
SUPFAMiSSF46919. SSF46919. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEiView protein in PROSITE
PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50876. ZF_INTEGRASE. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q72498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FFREDLAFPQ GKAREFSSEQ TRANSPTRRE LQVWGRDNNS LSEAGADRQG
60 70 80 90 100
TVSFSFPQIT LWQRPLVTIK IGGQLKEALL DTGADDTVLE EMNLPGRWKP
110 120 130 140 150
KMIGGIGGFI KVRQYDQILI EICGHKAIGT VLVGPTPVNI IGRNLLTQIG
160 170 180 190 200
CTLNFPISPI ETVPVKLKPG MDGPKVKQWP LTEEKIKALV EICTEMEKEG
210 220 230 240 250
KISKIGPENP YNTPVFAIKK KDSTKWRKLV DFRELNKRTQ DFWEVQLGIP
260 270 280 290 300
HPAGLKQKKS VTVLDVGDAY FSVPLDKDFR KYTAFTIPSI NNETPGIRYQ
310 320 330 340 350
YNVLPQGWKG SPAIFQCSMT KILEPFRKQN PDVVIYQYMD DLYVGSDLEI
360 370 380 390 400
GQHRTKIEEL RQHLLRWGFT TPDKKHQKEP PFLWMGYELH PDKWTVQPIV
410 420 430 440 450
LPEKDSWTVN DIQKLVGKLN WASQIYAGIK VRQLCKLLRG TKALTEVVPL
460 470 480 490 500
TEEAELELAE NREILKEPVH GVYYDPSKDL IAEIQKQGQG QWTYQIYQEP
510 520 530 540 550
FRNLKTGKYA RMKGAHTNDV KQLTEAVQKI ATESIVIWGK TPKFKLPIQK
560 570 580 590 600
ETWEAWWTEY WQATWIPEWE FVNTPPLVKL WYQLEKEPII GAETFYVDGA
610 620 630 640 650
ANRETKLGKA GYVTDRGRQK VVPLTDTTNQ KTELQAIHLA LQDSGLEVNI
660 670 680 690 700
VTDSQYALGI IQAQPDKSES ELVSQIIEQL IKKEKVYLAW VPAHKGIGGN
710 720 730 740 750
EQVDKLVSAG IRKVLFLDGI DKAQEEHEKY HSNWRAMASD FNLPPVVAKE
760 770 780 790 800
IVASCDKCQL KGEAMHGQVD CSPGIWQLDC THLEGKVILV AVHVASGYIE
810 820 830 840 850
AEVIPAETGQ ETAYFLLKLA GRWPVKTVHT DNGSNFTSTT VKAACWWAGI
860 870 880 890 900
KQEFGIPYNP QSQGVIESMN KELKKIIGQV RDQAEHLKTA VQMAVFIHNF
910 920 930 940 950
KRKGGIGGYS AGERIVDIIA TDIQTKELQK QITKIQNFRV YYRDSRDPVW
960 970 980 990 1000
KGPAKLLWKG EGAVVIQDNS DIKVVPRRKA KIIRDYGKQM AGDDCVASRQ

DED
Length:1,003
Mass (Da):113,720
Last modified:November 1, 1996 - v1
Checksum:i4E67C747EED795C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26942 Genomic DNA. Translation: AAB60572.1.
PIRiA47330.
B47330.
C47330.
D47330.
E47330.
F47330.
S32132.
S32140.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ72498_9HIV1
AccessioniPrimary (citable) accession number: Q72498
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported, Multifunctional enzymeSAAS annotation