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Q72497 (Q72497_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:gag EMBL AAB60571.1
OrganismHuman immunodeficiency virus 1 EMBL AAB60571.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex By similarity. SAAS SAAS000071

Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers By similarity. SAAS SAAS000071

Subcellular location

Virion By similarity RuleBase RU004487. Virion By similarity SAAS SAAS000071.

Post-translational modification

Specific enzymatic cleavages by the viral protease yield mature proteins By similarity. RuleBase RU004487

Sequence similarities

Contains CCHC-type zinc fingers. SAAS SAAS000071

Ontologies

Keywords
   Biological processHost-virus interaction
Viral budding
Viral budding via the host ESCRT complexes SAAS SAAS000071
Virus exit from host cell
   Cellular componentCapsid protein RuleBase RU000316 SAAS SAAS000071
Host cytoplasm SAAS SAAS000071 RuleBase RU004487
Host nucleus RuleBase RU004487 SAAS SAAS000071
Virion
   Coding sequence diversityRibosomal frameshifting SAAS SAAS000071
   DiseaseAIDS RuleBase RU004310
   DomainRepeat SAAS SAAS000071
Zinc-finger RuleBase RU000338 SAAS SAAS000071
   LigandMetal-binding
RNA-binding SAAS SAAS000071
Viral nucleoprotein RuleBase RU004487
Zinc
   Technical term3D-structure PDB 1L6N PDB 1M9X PDB 1M9E PDB 1M9F PDB 1M9Y PDB 1M9C PDB 2BUO PDB 3OBX PDB 3OBU PDB 3P0A
Gene Ontology (GO)
   Biological_processviral budding via host ESCRT complex

Inferred from electronic annotation. Source: UniProtKB-KW

viral release from host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

host cell nucleus

Inferred from electronic annotation. Source: UniProtKB-KW

viral nucleocapsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.5. Source: IntAct

structural molecule activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PPIAP629376EBI-1036263,EBI-437708From a different organism.

Sequences

Sequence LengthMass (Da)Tools
Q72497 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 08F450AC834088C6

FASTA50055,847
        10         20         30         40         50         60 
MGARASVLSG GELDKWEKIR LRPGGKKQYK LKHIVWASRE LERFAVNPGL LETSEGCRQI 

        70         80         90        100        110        120 
LGQLQPSLQT GSEELRSLYN TIAVLYCVHQ RIDVKDTKEA LDKIEEEQNK SKKKAQQAAA 

       130        140        150        160        170        180 
DTGNNSQVSQ NYPIVQNLQG QMVHQAISPR TLNAWVKVVE EKAFSPEVIP MFSALSEGAT 

       190        200        210        220        230        240 
PQDLNTMLNT VGGHQAAMQM LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT 

       250        260        270        280        290        300 
STLQEQIGWM THNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF 

       310        320        330        340        350        360 
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPG ATLEEMMTAC QGVGGPGHKA 

       370        380        390        400        410        420 
RVLAEAMSQV TNPATIMIQK GNFRNQRKTV KCFNCGKEGH IAKNCRAPRK KGCWKCGKEG 

       430        440        450        460        470        480 
HQMKDCTERQ ANFLGKIWPS HKGRPGNFLQ SRPEPTAPPE ESFRFGEETT TPSQRQEPID 

       490        500 
KELYPLASLR SLFGSDPSSQ 

« Hide

References

[1]"Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone."
Adachi A., Gendelman H.E., Koenig S., Folks T., Willey R., Rabson A., Martin M.A.
J. Virol. 59:284-291(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NL4-3 EMBL AAB60571.1.
[2]"Recovery of virtually full-length HIV-1 provirus of diverse subtypes from primary virus cultures using the polymerase chain reaction."
Salminen M.O., Koch C., Sanders-Buell E., Ehrenberg P.K., Michael N.L., Carr J.K., Burke D.S., McCutchan F.E.
Virology 213:80-86(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NL4-3 EMBL AAB60571.1.
[3]Salminen M.S.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NL4-3 EMBL AAB60571.1.
[4]"Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein."
Tang C., Ndassa Y., Summers M.F.
Nat. Struct. Biol. 9:537-543(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-283.
[5]"Structural insights into the catalytic mechanism of cyclophilin A."
Howard B.R., Vajdos F.F., Li S., Sundquist W.I., Hill C.P.
Nat. Struct. Biol. 10:475-481(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 133-278.
[6]"The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor."
Ternois F., Sticht J., Duquerroy S., Krausslich H.G., Rey F.A.
Nat. Struct. Mol. Biol. 12:678-682(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 278-363.
[7]"Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction."
Im Y.J., Kuo L., Ren X., Burgos P.V., Zhao X.Z., Liu F., Burke T.R., Bonifacino J.S., Freed E.O., Hurley J.H.
Structure 18:1536-1547(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 453-461.
[8]"Atomic-level modelling of the HIV capsid."
Pornillos O., Ganser-Pornillos B.K., Yeager M.
Nature 469:424-427(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.95 ANGSTROMS) OF 133-363.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U26942 Genomic DNA. Translation: AAB60571.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1L6NNMR-A1-283[»]
1M9CX-ray2.00C/D133-278[»]
1M9EX-ray1.72C/D133-278[»]
1M9FX-ray1.73C/D133-278[»]
1M9XX-ray1.70C/D/G/H133-278[»]
1M9YX-ray1.90C/D/G/H133-278[»]
2BUOX-ray1.70A278-363[»]
3OBUX-ray1.60B453-461[»]
3OBXX-ray1.60B453-461[»]
3P0AX-ray5.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T133-363[»]
ProteinModelPortalQ72497.
SMRQ72497. Positions 2-432, 449-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-36777N.
IntActQ72497. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProIPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_N_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSPR00234. HIV1MATRIX.
SMARTSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEPS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ72497.

Entry information

Entry nameQ72497_9HIV1
AccessionPrimary (citable) accession number: Q72497
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)