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Q72497

- Q72497_9HIV1

UniProt

Q72497 - Q72497_9HIV1

Protein
Submitted name:

Gag polyprotein

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.SAAS annotation
    Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers.SAAS annotation

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA binding Source: UniProtKB-KW
    3. structural molecule activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. viral budding via host ESCRT complex Source: UniProtKB-KW
    2. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Virus exit from host cell

    Keywords - Ligandi

    Metal-binding, RNA-bindingSAAS annotation, Viral nucleoproteinUniRule annotation, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Gag polyproteinImported
    Gene namesi
    Name:gagImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion UniRule annotation. Virion SAAS annotation

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-KW
    2. host cell nucleus Source: UniProtKB-KW
    3. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Post-translational modificationi

    Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPIAP629376EBI-1036263,EBI-437708From a different organism.

    Protein-protein interaction databases

    DIPiDIP-36777N.
    IntActiQ72497. 1 interaction.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1L6NNMR-A1-283[»]
    1M9CX-ray2.00C/D133-278[»]
    1M9EX-ray1.72C/D133-278[»]
    1M9FX-ray1.73C/D133-278[»]
    1M9XX-ray1.70C/D/G/H133-278[»]
    1M9YX-ray1.90C/D/G/H133-278[»]
    2BUOX-ray1.70A278-363[»]
    3OBUX-ray1.60B453-461[»]
    3OBXX-ray1.60B453-461[»]
    3P0AX-ray5.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T133-363[»]
    ProteinModelPortaliQ72497.
    SMRiQ72497. Positions 2-432, 449-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ72497.

    Family & Domainsi

    Sequence similaritiesi

    Contains CCHC-type zinc fingers.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

    Family and domain databases

    Gene3Di1.10.1200.30. 1 hit.
    1.10.150.90. 1 hit.
    1.10.375.10. 1 hit.
    4.10.60.10. 1 hit.
    InterProiIPR000721. Gag_p24.
    IPR014817. Gag_p6.
    IPR000071. Lentvrl_matrix_N.
    IPR012344. Matrix_N_HIV/RSV.
    IPR008916. Retrov_capsid_C.
    IPR008919. Retrov_capsid_N.
    IPR010999. Retrovr_matrix_N.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00540. Gag_p17. 1 hit.
    PF00607. Gag_p24. 1 hit.
    PF08705. Gag_p6. 1 hit.
    PF00098. zf-CCHC. 2 hits.
    [Graphical view]
    PRINTSiPR00234. HIV1MATRIX.
    SMARTiSM00343. ZnF_C2HC. 2 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    SSF47836. SSF47836. 1 hit.
    SSF47943. SSF47943. 1 hit.
    SSF57756. SSF57756. 1 hit.
    PROSITEiPS50158. ZF_CCHC. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q72497-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGARASVLSG GELDKWEKIR LRPGGKKQYK LKHIVWASRE LERFAVNPGL    50
    LETSEGCRQI LGQLQPSLQT GSEELRSLYN TIAVLYCVHQ RIDVKDTKEA 100
    LDKIEEEQNK SKKKAQQAAA DTGNNSQVSQ NYPIVQNLQG QMVHQAISPR 150
    TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM 200
    LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT STLQEQIGWM 250
    THNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF 300
    YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPG ATLEEMMTAC 350
    QGVGGPGHKA RVLAEAMSQV TNPATIMIQK GNFRNQRKTV KCFNCGKEGH 400
    IAKNCRAPRK KGCWKCGKEG HQMKDCTERQ ANFLGKIWPS HKGRPGNFLQ 450
    SRPEPTAPPE ESFRFGEETT TPSQRQEPID KELYPLASLR SLFGSDPSSQ 500
    Length:500
    Mass (Da):55,847
    Last modified:November 1, 1996 - v1
    Checksum:i08F450AC834088C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U26942 Genomic DNA. Translation: AAB60571.1.

    Keywords - Coding sequence diversityi

    Ribosomal frameshiftingSAAS annotation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U26942 Genomic DNA. Translation: AAB60571.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1L6N NMR - A 1-283 [» ]
    1M9C X-ray 2.00 C/D 133-278 [» ]
    1M9E X-ray 1.72 C/D 133-278 [» ]
    1M9F X-ray 1.73 C/D 133-278 [» ]
    1M9X X-ray 1.70 C/D/G/H 133-278 [» ]
    1M9Y X-ray 1.90 C/D/G/H 133-278 [» ]
    2BUO X-ray 1.70 A 278-363 [» ]
    3OBU X-ray 1.60 B 453-461 [» ]
    3OBX X-ray 1.60 B 453-461 [» ]
    3P0A X-ray 5.95 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T 133-363 [» ]
    ProteinModelPortali Q72497.
    SMRi Q72497. Positions 2-432, 449-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-36777N.
    IntActi Q72497. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q72497.

    Family and domain databases

    Gene3Di 1.10.1200.30. 1 hit.
    1.10.150.90. 1 hit.
    1.10.375.10. 1 hit.
    4.10.60.10. 1 hit.
    InterProi IPR000721. Gag_p24.
    IPR014817. Gag_p6.
    IPR000071. Lentvrl_matrix_N.
    IPR012344. Matrix_N_HIV/RSV.
    IPR008916. Retrov_capsid_C.
    IPR008919. Retrov_capsid_N.
    IPR010999. Retrovr_matrix_N.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00540. Gag_p17. 1 hit.
    PF00607. Gag_p24. 1 hit.
    PF08705. Gag_p6. 1 hit.
    PF00098. zf-CCHC. 2 hits.
    [Graphical view ]
    PRINTSi PR00234. HIV1MATRIX.
    SMARTi SM00343. ZnF_C2HC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    SSF47836. SSF47836. 1 hit.
    SSF47943. SSF47943. 1 hit.
    SSF57756. SSF57756. 1 hit.
    PROSITEi PS50158. ZF_CCHC. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone."
      Adachi A., Gendelman H.E., Koenig S., Folks T., Willey R., Rabson A., Martin M.A.
      J. Virol. 59:284-291(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NL4-3Imported.
    2. "Recovery of virtually full-length HIV-1 provirus of diverse subtypes from primary virus cultures using the polymerase chain reaction."
      Salminen M.O., Koch C., Sanders-Buell E., Ehrenberg P.K., Michael N.L., Carr J.K., Burke D.S., McCutchan F.E.
      Virology 213:80-86(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NL4-3Imported.
    3. Salminen M.S.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NL4-3Imported.
    4. "Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein."
      Tang C., Ndassa Y., Summers M.F.
      Nat. Struct. Biol. 9:537-543(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-283.
    5. "Structural insights into the catalytic mechanism of cyclophilin A."
      Howard B.R., Vajdos F.F., Li S., Sundquist W.I., Hill C.P.
      Nat. Struct. Biol. 10:475-481(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 133-278.
    6. "The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor."
      Ternois F., Sticht J., Duquerroy S., Krausslich H.G., Rey F.A.
      Nat. Struct. Mol. Biol. 12:678-682(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 278-363.
    7. "Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction."
      Im Y.J., Kuo L., Ren X., Burgos P.V., Zhao X.Z., Liu F., Burke T.R., Bonifacino J.S., Freed E.O., Hurley J.H.
      Structure 18:1536-1547(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 453-461.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (5.95 ANGSTROMS) OF 133-363.

    Entry informationi

    Entry nameiQ72497_9HIV1
    AccessioniPrimary (citable) accession number: Q72497
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3