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Q72497

- Q72497_9HIV1

UniProt

Q72497 - Q72497_9HIV1

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Protein

Gag polyprotein

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.SAAS annotation
Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers.SAAS annotation

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. structural molecule activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. viral budding via host ESCRT complex Source: UniProtKB-KW
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Virus exit from host cell

Keywords - Ligandi

Metal-binding, RNA-bindingSAAS annotation, Viral nucleoproteinUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinSAAS annotation
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion UniRule annotation. Virion SAAS annotation

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cell nucleus Source: UniProtKB-KW
  3. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Post-translational modificationi

Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPIAP629376EBI-1036263,EBI-437708From a different organism.

Protein-protein interaction databases

DIPiDIP-36777N.
IntActiQ72497. 1 interaction.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L6NNMR-A1-283[»]
1M9CX-ray2.00C/D133-278[»]
1M9EX-ray1.72C/D133-278[»]
1M9FX-ray1.73C/D133-278[»]
1M9XX-ray1.70C/D/G/H133-278[»]
1M9YX-ray1.90C/D/G/H133-278[»]
2BUOX-ray1.70A278-363[»]
3OBUX-ray1.60B453-461[»]
3OBXX-ray1.60B453-461[»]
3P0AX-ray5.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T133-363[»]
ProteinModelPortaliQ72497.
SMRiQ72497. Positions 2-432, 449-500.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72497.

Family & Domainsi

Sequence similaritiesi

Contains CCHC-type zinc fingers.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_N_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72497-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGARASVLSG GELDKWEKIR LRPGGKKQYK LKHIVWASRE LERFAVNPGL
60 70 80 90 100
LETSEGCRQI LGQLQPSLQT GSEELRSLYN TIAVLYCVHQ RIDVKDTKEA
110 120 130 140 150
LDKIEEEQNK SKKKAQQAAA DTGNNSQVSQ NYPIVQNLQG QMVHQAISPR
160 170 180 190 200
TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM
210 220 230 240 250
LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT STLQEQIGWM
260 270 280 290 300
THNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF
310 320 330 340 350
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPG ATLEEMMTAC
360 370 380 390 400
QGVGGPGHKA RVLAEAMSQV TNPATIMIQK GNFRNQRKTV KCFNCGKEGH
410 420 430 440 450
IAKNCRAPRK KGCWKCGKEG HQMKDCTERQ ANFLGKIWPS HKGRPGNFLQ
460 470 480 490 500
SRPEPTAPPE ESFRFGEETT TPSQRQEPID KELYPLASLR SLFGSDPSSQ
Length:500
Mass (Da):55,847
Last modified:November 1, 1996 - v1
Checksum:i08F450AC834088C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26942 Genomic DNA. Translation: AAB60571.1.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26942 Genomic DNA. Translation: AAB60571.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1L6N NMR - A 1-283 [» ]
1M9C X-ray 2.00 C/D 133-278 [» ]
1M9E X-ray 1.72 C/D 133-278 [» ]
1M9F X-ray 1.73 C/D 133-278 [» ]
1M9X X-ray 1.70 C/D/G/H 133-278 [» ]
1M9Y X-ray 1.90 C/D/G/H 133-278 [» ]
2BUO X-ray 1.70 A 278-363 [» ]
3OBU X-ray 1.60 B 453-461 [» ]
3OBX X-ray 1.60 B 453-461 [» ]
3P0A X-ray 5.95 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T 133-363 [» ]
ProteinModelPortali Q72497.
SMRi Q72497. Positions 2-432, 449-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-36777N.
IntActi Q72497. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q72497.

Family and domain databases

Gene3Di 1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProi IPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_N_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix_N.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view ]
PRINTSi PR00234. HIV1MATRIX.
SMARTi SM00343. ZnF_C2HC. 2 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEi PS50158. ZF_CCHC. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone."
    Adachi A., Gendelman H.E., Koenig S., Folks T., Willey R., Rabson A., Martin M.A.
    J. Virol. 59:284-291(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NL4-3Imported.
  2. "Recovery of virtually full-length HIV-1 provirus of diverse subtypes from primary virus cultures using the polymerase chain reaction."
    Salminen M.O., Koch C., Sanders-Buell E., Ehrenberg P.K., Michael N.L., Carr J.K., Burke D.S., McCutchan F.E.
    Virology 213:80-86(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NL4-3Imported.
  3. Salminen M.S.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NL4-3Imported.
  4. "Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein."
    Tang C., Ndassa Y., Summers M.F.
    Nat. Struct. Biol. 9:537-543(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-283.
  5. "Structural insights into the catalytic mechanism of cyclophilin A."
    Howard B.R., Vajdos F.F., Li S., Sundquist W.I., Hill C.P.
    Nat. Struct. Biol. 10:475-481(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 133-278.
  6. "The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor."
    Ternois F., Sticht J., Duquerroy S., Krausslich H.G., Rey F.A.
    Nat. Struct. Mol. Biol. 12:678-682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 278-363.
  7. "Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction."
    Im Y.J., Kuo L., Ren X., Burgos P.V., Zhao X.Z., Liu F., Burke T.R., Bonifacino J.S., Freed E.O., Hurley J.H.
    Structure 18:1536-1547(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 453-461.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (5.95 ANGSTROMS) OF 133-363.

Entry informationi

Entry nameiQ72497_9HIV1
AccessioniPrimary (citable) accession number: Q72497
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3