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Protein

Gag polyprotein

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinUniRule annotation
Biological processHost-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Viral release from host cell
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotationSAAS annotation
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000160754 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host cytoplasm UniRule annotationSAAS annotation
  • Host nucleus UniRule annotationSAAS annotation
  • Virion UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Chemistry databases

DrugBankiDB08231 Myristic acid

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPIAP629377EBI-1036263,EBI-437708From Homo sapiens.

Protein-protein interaction databases

DIPiDIP-36777N
IntActiQ72497, 3 interactors

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L6NNMR-A1-283[»]
1M9CX-ray2.00C/D133-278[»]
1M9EX-ray1.72C/D133-278[»]
1M9FX-ray1.73C/D133-278[»]
1M9XX-ray1.70C/D/G/H133-278[»]
1M9YX-ray1.90C/D/G/H133-278[»]
3OBUX-ray1.60B453-461[»]
3OBXX-ray1.60B453-461[»]
3P0AX-ray5.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T133-363[»]
5I4TX-ray3.27G/H/I/J/K/L278-377[»]
5MCZelectron microscopy8.20A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD0electron microscopy8.40A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD1electron microscopy8.20A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD2electron microscopy8.60A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD3electron microscopy8.50A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD4electron microscopy8.40A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD5electron microscopy8.20A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD6electron microscopy8.10A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD7electron microscopy8.40A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD8electron microscopy8.60A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MD9electron microscopy8.00A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MDAelectron microscopy8.40A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MDBelectron microscopy8.40A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MDCelectron microscopy8.40A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MDDelectron microscopy8.50A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MDEelectron microscopy8.40A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MDFelectron microscopy8.50A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
5MDGelectron microscopy8.70A/B/C/D/E/F/G/W280-353[»]
H/I/J/a/b/f133-279[»]
ProteinModelPortaliQ72497
SMRiQ72497
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72497

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 406CCHC-typeInterPro annotationAdd BLAST16
Domaini413 – 428CCHC-typeInterPro annotationAdd BLAST16

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 121Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the primate lentivirus group gag polyprotein family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30, 1 hit
1.10.150.90, 1 hit
1.10.375.10, 1 hit
InterProiView protein in InterPro
IPR000721 Gag_p24
IPR014817 Gag_p6
IPR000071 Lentvrl_matrix_N
IPR012344 Matrix_HIV/RSV_N
IPR008916 Retrov_capsid_C
IPR008919 Retrov_capsid_N
IPR010999 Retrovr_matrix
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00540 Gag_p17, 1 hit
PF00607 Gag_p24, 1 hit
PF08705 Gag_p6, 1 hit
PF00098 zf-CCHC, 2 hits
PRINTSiPR00234 HIV1MATRIX
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 2 hits
SUPFAMiSSF47836 SSF47836, 1 hit
SSF47943 SSF47943, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 2 hits

Sequencei

Sequence statusi: Complete.

Q72497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASVLSG GELDKWEKIR LRPGGKKQYK LKHIVWASRE LERFAVNPGL
60 70 80 90 100
LETSEGCRQI LGQLQPSLQT GSEELRSLYN TIAVLYCVHQ RIDVKDTKEA
110 120 130 140 150
LDKIEEEQNK SKKKAQQAAA DTGNNSQVSQ NYPIVQNLQG QMVHQAISPR
160 170 180 190 200
TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM
210 220 230 240 250
LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT STLQEQIGWM
260 270 280 290 300
THNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF
310 320 330 340 350
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPG ATLEEMMTAC
360 370 380 390 400
QGVGGPGHKA RVLAEAMSQV TNPATIMIQK GNFRNQRKTV KCFNCGKEGH
410 420 430 440 450
IAKNCRAPRK KGCWKCGKEG HQMKDCTERQ ANFLGKIWPS HKGRPGNFLQ
460 470 480 490 500
SRPEPTAPPE ESFRFGEETT TPSQRQEPID KELYPLASLR SLFGSDPSSQ
Length:500
Mass (Da):55,847
Last modified:November 1, 1996 - v1
Checksum:i08F450AC834088C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26942 Genomic DNA Translation: AAB60571.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Similar proteinsi

Entry informationi

Entry nameiQ72497_9HIV1
AccessioniPrimary (citable) accession number: Q72497
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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