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Q723E1 (KPRS2_LISMF) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase 2

Short name=RPPK 2
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 2
Short name=P-Rib-PP synthase 2
Short name=PRPP synthase 2
Gene names
Name:prs2
Ordered Locus Names:LMOf2365_0538
OrganismListeria monocytogenes serotype 4b (strain F2365) [Complete proteome] [HAMAP]
Taxonomic identifier265669 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesListeriaceaeListeria

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583_B

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583_B

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583_B

Subcellular location

Cytoplasm By similarity HAMAP MF_00583_B.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Ribose-phosphate pyrophosphokinase 2 HAMAP MF_00583_B
PRO_0000141156

Regions

Region212 – 22514Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1291Magnesium Potential
Metal binding1311Magnesium Potential
Metal binding1401Magnesium Potential
Metal binding1441Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q723E1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 82F9270DB1B0D529

FASTA31134,346
        10         20         30         40         50         60 
MAGKMKLFSV TSERPLATKI ADYLDIPLCE VELQKFSDGE VKINIEESIR GTNAYVVQSM 

        70         80         90        100        110        120 
NSNVNERLME LLIMVDALKR ASVHSINIIM PYYGYARQDR KARSREPITA KLMANLIQRA 

       130        140        150        160        170        180 
GADRLITVDL HAAQIQGFFN IPIDHLSAIP LIGDYLIENY GEKDVVVVAP DHSGVVRARR 

       190        200        210        220        230        240 
IADRLNAPIA ILNRKPRPHE DEIMSVIGDV KGKVAIVVDD IIDTGVRATT SADILLEKGA 

       250        260        270        280        290        300 
VEVIACATHS VMAGNATERL QNSNIKEVIT SDSIDLPEDK QFDKLTTISI GRILGRAIEG 

       310 
VQENRSLHPL F 

« Hide

References

[1]"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species."
Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J. expand/collapse author list , Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M.
Nucleic Acids Res. 32:2386-2395(2004) [PubMed: 15115801] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F2365.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017262 Genomic DNA. Translation: AAT03320.1.
RefSeqYP_013143.1. NC_002973.6.

3D structure databases

ProteinModelPortalQ723E1.
SMRQ723E1. Positions 4-311.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ723E1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2798065.
GenomeReviewsGene locus LMOf2365_0538 in contig AE017262_GR.
KEGGlmf:LMOf2365_0538.
PATRIC20322281. VBILisMon105049_0538.
TIGRLMOf2365_0538.

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHBG519284.
OMAELMIMIN.
PhylomeDBQ723E1.
ProtClustDBCLSK563942.

Enzyme and pathway databases

BioCycLMON265669:LMOF2365_0538-MONOMER.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
[Tree]
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase.
IPR005946. Rib-P_diPkinase.
[Graphical view]
KOK00948.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. RibP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS2_LISMF
AccessionPrimary (citable) accession number: Q723E1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families