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Q722Y3

- HISX_LISMF

UniProt

Q722Y3 - HISX_LISMF

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei232 – 2321SubstrateUniRule annotation
    Metal bindingi254 – 2541ZincUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Metal bindingi257 – 2571ZincUniRule annotation
    Binding sitei257 – 2571SubstrateUniRule annotation
    Active sitei322 – 3221Proton acceptorUniRule annotation
    Active sitei323 – 3231Proton acceptorUniRule annotation
    Binding sitei323 – 3231SubstrateUniRule annotation
    Metal bindingi356 – 3561ZincUniRule annotation
    Binding sitei356 – 3561SubstrateUniRule annotation
    Binding sitei410 – 4101SubstrateUniRule annotation
    Metal bindingi415 – 4151ZincUniRule annotation
    Binding sitei415 – 4151SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:LMOf2365_0596
    OrganismiListeria monocytogenes serotype 4b (strain F2365)
    Taxonomic identifieri265669 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000563: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Histidinol dehydrogenasePRO_0000135792Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi265669.LMOf2365_0596.

    Structurei

    3D structure databases

    ProteinModelPortaliQ722Y3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q722Y3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILTGTVNE LLNELKIETD TNTSIQVETE VKTIIEKVKT AGDQALFDFT    50
    SKFDGVGLTE LRVPAADIQA ASAKIEPAFL DALQQAKVNI ESFHSKQKQH 100
    AFLDSEKDGV IRGQLIRPLE TVGVYVPGGT AAYPSSVLMN VLPAKIAGVK 150
    RIVMITPPGE NGINPYVLAS AQLAGVDEIY QVGGAHGIAA LAHGTESIPK 200
    VDKIVGPGNI YVATAKREVF GLVDIDMIAG PSEIVVLADE NANPAFIAAD 250
    LLSQAEHDIL ARAILITTSK KIAEETQNEI DKQLENLPRK AIAQKSIETR 300
    GKIIIAATTQ EMFDIMNEIA PEHLEVQLEN PMNYLYQIKN AGSIFLGSYA 350
    SEPLGDYFAG PNHVLPTSGT AKFFSPLGVE DFTKRSAFIS YTKEALAKEK 400
    DAIVLLAKKE GLDAHAKAIQ IRFEEEN 427
    Length:427
    Mass (Da):46,147
    Last modified:July 5, 2004 - v1
    Checksum:i015FC5F410CC90A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017262 Genomic DNA. Translation: AAT03378.1.
    RefSeqiYP_013201.1. NC_002973.6.

    Genome annotation databases

    EnsemblBacteriaiAAT03378; AAT03378; LMOf2365_0596.
    GeneIDi2798888.
    KEGGilmf:LMOf2365_0596.
    PATRICi20322395. VBILisMon105049_0595.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017262 Genomic DNA. Translation: AAT03378.1 .
    RefSeqi YP_013201.1. NC_002973.6.

    3D structure databases

    ProteinModelPortali Q722Y3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265669.LMOf2365_0596.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT03378 ; AAT03378 ; LMOf2365_0596 .
    GeneIDi 2798888.
    KEGGi lmf:LMOf2365_0596.
    PATRICi 20322395. VBILisMon105049_0595.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: F2365.

    Entry informationi

    Entry nameiHISX_LISMF
    AccessioniPrimary (citable) accession number: Q722Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3