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Q722Y3

- HISX_LISMF

UniProt

Q722Y3 - HISX_LISMF

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Protein
Histidinol dehydrogenase
Gene
hisD, LMOf2365_0596
Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Metal bindingi257 – 2571Zinc By similarity
Binding sitei257 – 2571Substrate By similarity
Active sitei322 – 3221Proton acceptor By similarity
Active sitei323 – 3231Proton acceptor By similarity
Binding sitei323 – 3231Substrate By similarity
Metal bindingi356 – 3561Zinc By similarity
Binding sitei356 – 3561Substrate By similarity
Binding sitei410 – 4101Substrate By similarity
Metal bindingi415 – 4151Zinc By similarity
Binding sitei415 – 4151Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:LMOf2365_0596
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000563: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Histidinol dehydrogenaseUniRule annotation
PRO_0000135792Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265669.LMOf2365_0596.

Structurei

3D structure databases

ProteinModelPortaliQ722Y3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q722Y3-1 [UniParc]FASTAAdd to Basket

« Hide

MKILTGTVNE LLNELKIETD TNTSIQVETE VKTIIEKVKT AGDQALFDFT    50
SKFDGVGLTE LRVPAADIQA ASAKIEPAFL DALQQAKVNI ESFHSKQKQH 100
AFLDSEKDGV IRGQLIRPLE TVGVYVPGGT AAYPSSVLMN VLPAKIAGVK 150
RIVMITPPGE NGINPYVLAS AQLAGVDEIY QVGGAHGIAA LAHGTESIPK 200
VDKIVGPGNI YVATAKREVF GLVDIDMIAG PSEIVVLADE NANPAFIAAD 250
LLSQAEHDIL ARAILITTSK KIAEETQNEI DKQLENLPRK AIAQKSIETR 300
GKIIIAATTQ EMFDIMNEIA PEHLEVQLEN PMNYLYQIKN AGSIFLGSYA 350
SEPLGDYFAG PNHVLPTSGT AKFFSPLGVE DFTKRSAFIS YTKEALAKEK 400
DAIVLLAKKE GLDAHAKAIQ IRFEEEN 427
Length:427
Mass (Da):46,147
Last modified:July 5, 2004 - v1
Checksum:i015FC5F410CC90A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017262 Genomic DNA. Translation: AAT03378.1.
RefSeqiYP_013201.1. NC_002973.6.

Genome annotation databases

EnsemblBacteriaiAAT03378; AAT03378; LMOf2365_0596.
GeneIDi2798888.
KEGGilmf:LMOf2365_0596.
PATRICi20322395. VBILisMon105049_0595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017262 Genomic DNA. Translation: AAT03378.1 .
RefSeqi YP_013201.1. NC_002973.6.

3D structure databases

ProteinModelPortali Q722Y3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 265669.LMOf2365_0596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT03378 ; AAT03378 ; LMOf2365_0596 .
GeneIDi 2798888.
KEGGi lmf:LMOf2365_0596.
PATRICi 20322395. VBILisMon105049_0595.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F2365.

Entry informationi

Entry nameiHISX_LISMF
AccessioniPrimary (citable) accession number: Q722Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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