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Q722H1 (GLMS_LISMF) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

EC=2.6.1.16
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene names
Name:glmS
Ordered Locus Names:LMOf2365_0762
OrganismListeria monocytogenes serotype 4b (strain F2365) [Complete proteome] [HAMAP]
Taxonomic identifier265669 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity. HAMAP-Rule MF_00164

Catalytic activity

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. HAMAP-Rule MF_00164

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00164

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00164.

Sequence similarities

Contains 1 glutamine amidotransferase type-2 domain.

Contains 2 SIS domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 601600Glutamine--fructose-6-phosphate aminotransferase [isomerizing] HAMAP-Rule MF_00164
PRO_0000135352

Regions

Domain2 – 216215Glutamine amidotransferase type-2
Domain282 – 421140SIS 1
Domain453 – 591139SIS 2

Sites

Active site21Nucleophile; for GATase activity By similarity
Active site5961For Fru-6P isomerization activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q722H1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: AD427F6F6812EA15

FASTA60165,647
        10         20         30         40         50         60 
MCGIVGYIGT NNAKSILLEG LEKLEYRGYD SAGIALQNKD LVTVVKEKGR IADLASLVPS 

        70         80         90        100        110        120 
DAFGTTGIGH TRWATHGKPN HENAHPHQSK SGRFTMVHNG VIENYTLLKE EYLKNHSFVS 

       130        140        150        160        170        180 
DTDTEVIVQL IELFAAELST KEAFKKALSL LHGSYAICLI DQTDTETLYA AKNKSPLLIG 

       190        200        210        220        230        240 
KGENFNVIAS DAMAVLKETD EFVEIMDKEI VIVTKDGFTL ETLEGEEISR ASYTAELDAS 

       250        260        270        280        290        300 
DIEKGTYPHY MLKEIDEQPA VTRKIIQAYQ NEAGEINVDQ TILDEILSSD RIHIVACGTS 

       310        320        330        340        350        360 
YHAGLVGKNL IEKMAKIPVE VHVSSEFGYN LPLMSKKPLF IFITQSGETA DSRQCLVKVK 

       370        380        390        400        410        420 
ELGYRTLTLT NVPGSTLDRE ADHSMYLYAG PEIAVASTKA YTAQISVLAV LAVSLGREIG 

       430        440        450        460        470        480 
DAEALSINLA AELGIVATAM EAMVSSKEVI EHIAGEYLAT SRNAFFLGRN IDYFVAMEAA 

       490        500        510        520        530        540 
LKLKEISYIQ AEGFASGELK HGTIALIEDG TPVLALITQE SINWNIRGNV NEVLARGAKT 

       550        560        570        580        590        600 
CVFAMENVAQ PGDRFVIPQV HPLLTPLASV IPCQLLAYYA ALHRDCDVDK PRNLAKSVTV 


E 

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References

[1]"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species."
Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J. expand/collapse author list , Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M.
Nucleic Acids Res. 32:2386-2395(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F2365.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017262 Genomic DNA. Translation: AAT03543.1.
RefSeqYP_013366.1. NC_002973.6.

3D structure databases

ProteinModelPortalQ722H1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING265669.LMOf2365_0762.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT03543; AAT03543; LMOf2365_0762.
GeneID2798214.
KEGGlmf:LMOf2365_0762.
PATRIC20322738. VBILisMon105049_0764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0449.
HOGENOMHOG000258896.
KOK00820.
OMAPVTRRFM.
OrthoDBEOG6KT2Q1.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
HAMAPMF_00164. GlmS.
InterProIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
TIGRFAMsTIGR01135. glmS. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLMS_LISMF
AccessionPrimary (citable) accession number: Q722H1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families