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Protein

D-alanine--poly(phosphoribitol) ligase subunit 1

Gene

dltA

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp.UniRule annotation

Catalytic activityi

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).UniRule annotation

Pathwayi: lipoteichoic acid biosynthesis

This protein is involved in the pathway lipoteichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipoteichoic acid biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

  • acid-amino acid ligase activity Source: JCVI
  • AMP binding Source: JCVI
  • ATP binding Source: UniProtKB-KW
  • D-alanine-poly(phosphoribitol) ligase activity Source: UniProtKB-EC
  • transmembrane transporter activity Source: JCVI

GO - Biological processi

  • lipoteichoic acid biosynthetic process Source: UniProtKB-UniPathway
  • peptidoglycan biosynthetic process Source: JCVI
  • transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00556.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 1UniRule annotation (EC:6.1.1.13UniRule annotation)
Alternative name(s):
D-alanine-D-alanyl carrier protein ligaseUniRule annotation
Short name:
DCLUniRule annotation
D-alanine-activating enzymeUniRule annotation
Short name:
DAEUniRule annotation
Gene namesi
Name:dltAUniRule annotation
Ordered Locus Names:LMOf2365_0994
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510D-alanine--poly(phosphoribitol) ligase subunit 1PRO_0000213147Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ721J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229995.
KOiK03367.
OMAiAQVIPTN.
OrthoDBiEOG6QP0WP.

Family and domain databases

HAMAPiMF_00593. DltA.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. DltA.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q721J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSIIERID AWAEKTPDFP CYEYAGTRLS YKELKRQSDA FGSFLLKNLN
60 70 80 90 100
TDKEKPIIVY GHMSPLMLVA FLGSIKSGRA YVPVDVSMPV ERIEQIKKAA
110 120 130 140 150
DPSLFICTEE LPSNLTITGC PVLTQDQLMD ALEKHFGEVP DKEACVKNDD
160 170 180 190 200
NYYIIYTSGS TGNPKGVQIS QNNLVSFSNW ILQDFSLSQG LRFLNQAPFS
210 220 230 240 250
FDLSVMDLYP SLLSGGTLVP LDKTITANMK DLYREIPAQN LDVWVSTPSF
260 270 280 290 300
ADLCLLDDNF NQENNPGLIR FLFCGEVLAK KTASELLNRF PDAVIYNTYG
310 320 330 340 350
PTEATVAVTQ VKVTREVIDA YPSLPLGVIK PDMRLHIVDQ ETGEVLPEGE
360 370 380 390 400
KGEIVLIGAS VSKGYLNEPE KTDQVFFDYK GYQAYRTGDS GIIKDGYLFF
410 420 430 440 450
QGRLDFQIKL HGYRIELEDI ENNLKKVSYI QNCAIIPKMK DEKVDMLVAQ
460 470 480 490 500
VIPTNHDFEK EYQLSAAIKN ELKEFMPAYM IPRKWIYKTE FPLTMNGKID
510
RKALNSEVNK
Length:510
Mass (Da):57,613
Last modified:July 5, 2004 - v1
Checksum:i8AE9326D9D3A8FE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT03772.1.
RefSeqiWP_003727064.1. NC_002973.6.

Genome annotation databases

EnsemblBacteriaiAAT03772; AAT03772; LMOf2365_0994.
KEGGilmf:LMOf2365_0994.
PATRICi20323214. VBILisMon105049_0997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT03772.1.
RefSeqiWP_003727064.1. NC_002973.6.

3D structure databases

ProteinModelPortaliQ721J2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT03772; AAT03772; LMOf2365_0994.
KEGGilmf:LMOf2365_0994.
PATRICi20323214. VBILisMon105049_0997.

Phylogenomic databases

HOGENOMiHOG000229995.
KOiK03367.
OMAiAQVIPTN.
OrthoDBiEOG6QP0WP.

Enzyme and pathway databases

UniPathwayiUPA00556.

Family and domain databases

HAMAPiMF_00593. DltA.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. DltA.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F2365.

Entry informationi

Entry nameiDLTA_LISMF
AccessioniPrimary (citable) accession number: Q721J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.